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J Thorac Cardiovasc Surg 2006;132:734
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Reply to the Editor

Domenico Paparella, MD, Antonella Galeone, MD, Giuseppe Scrascia, MD

Division of Cardiac Surgery, University of Bari, Piazza Giulio Cesare 11, Bari 70100, Italy

(Email: paparella@tin.it).

The first 20% of the full text of this article appears below.

Thank you for the invitation to respond to Dr Casati and colleagues' letter. We used an in vitro bleeding time test (Platelet Function Analyzer [PFA]-100) to evaluate platelet function perioperatively at 7 different observation times. Only one of these observations was performed during cardiopulmonary bypass with hemodiluted patients. Fibrinolytic activity can indirectly be measured, evaluating the balance between the promoter of fibrinolysis (tissue-type plasminogen activator) and its inhibitor (plasminogen activator inhibitor 1). In our study1Go we observed that tissue-type plasminogen activator levels are not increased, whereas plasminogen activator inhibitor 1 and D-dimer levels are modestly increased after off-pump coronary . . . [Full Text of this Article]


Related Article

About the activation of the coagulation system during on-pump and off-pump coronary surgery and the use of antifibrinolytic drugs
Valter Casati, Francisco Guerra, and Armando D'Angelo
J. Thorac. Cardiovasc. Surg. 2006 132: 733-734. [Extract] [Full Text] [PDF]





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