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Joseph S. Coselli
Scott A. LeMaire
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J Thorac Cardiovasc Surg 2006;132:988-989
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Reply to the Editor

Li Chen, PhD, Xing Li Wang, MD, PhD, Joseph S. Coselli, MD, Scott A. LeMaire, MD

Texas Heart Institute at St Luke's Episcopal Hospital, Baylor College of Medicine, Houston, Tex

The first 20% of the full text of this article appears below.

We appreciate the comments by Ahmad and colleagues regarding our initial investigation of single nucleotide polymorphisms (SNPs) involving the matrix metalloproteinase 9 gene (MMP9) in patients with thoracic aortic pathology.1Go Selection of a control group that is perfectly matched for ethnic ancestry with a group of affected individuals is indeed a major challenge in studying the associations between candidate genes and diseases. Not surprisingly, most published studies have imperfectly matched case-control populations. Nevertheless, the substantial geographic difference between our control and study populations clearly warrants discussion.

Although geographically diverse, white populations from Australia and the United States are genetically similar. The majority of the white Australian population has ancestors who, within only a few generations, originated from the European continent. Previous studies of other genetic polymorphisms have demonstrated great similarities between the white Australian population and white subjects residing on . . . [Full Text of this Article]


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Candidate gene association analysis of thoracic aortic aneurysm and dissection
Usman Ahmad, Muhammad A. Javed, and Saulat H. Fatimi
J. Thorac. Cardiovasc. Surg. 2006 132: 988. [Extract] [Full Text] [PDF]





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