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J Thorac Cardiovasc Surg 2006;132:1279
© 2006 The American Association for Thoracic Surgery


Surgery for Congenital Heart Disease

Discussion

The first 20% of the full text of this article appears below.

Dr Frank W. Sellke (Boston, Mass). This is a very nice in vitro study of the effects of overexpression of ILK on cardiac stem cell growth.

I have a couple questions. Was the purpose of this study just to increase expansion of the stem cell population, or do you think that it perhaps could overcome some of the negative influences of ischemia, diabetes, and similar issues on stem cell engraftment and function?

Second, do you have any evidence from in vivo studies that this will be translated into a physiologic or potentially a clinical benefit?

Finally, how . . . [Full Text of this Article]


Related Article

Overexpression of integrin-linked kinase induces cardiac stem cell expansion
Hideaki Yamabi, Huanzhang Lu, Xiaojing Dai, Yanruo Lu, Gregory Hannigan, and John G. Coles
J. Thorac. Cardiovasc. Surg. 2006 132: 1272-1279. [Abstract] [Full Text] [PDF]






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