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J Thorac Cardiovasc Surg 2006;132:1467-1468
© 2006 The American Association for Thoracic Surgery

Brief Communication

Giant cell aortitis with histopathologic and clinical response to steroid therapy: A case report

Howard Blumstein, MDa, Leslie Dubin Kerr, MDa,*, John T. Fallon, MD, PhDb

a Department of Medicine, Division of Rheumatology, Mount Sinai School of Medicine, New York, NY
b Department of Pathology and the Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY.

* Address for reprints: Leslie D. Kerr, MD, Box 1244, Division of Rheumatology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029-6574. (Email: leslie.kerr@mssm.edu).

The first 20% of the full text of this article appears below.

Giant cell arteritis (GCA) is a large-vessel vasculitis that affects older individuals and typically presents with constitutional symptoms, polymyalgia, headache, scalp tenderness, jaw claudication, or sudden vision loss.1Go

A subset of patients with GCA can present with large artery disease consisting of aortic aneurysm, dissection, or both.2Go We have also recently described our own experience with 19 such patients who underwent surgical repair of aortic aneurysms and who were found to have unsuspected giant cell aortitis on histopathologic review.3Go This study suggested that large-vessel giant cell aortitis might be a different disease from classic GCA because of its unusual clinical presentation. No conclusions, however, could be drawn regarding the effectiveness of subsequent steroid therapy for this variant of the disease.

A unique opportunity to explore this question arose when a patient with 2 known aortic aneurysms presented. Giant cell aortitis was documented at the repair of the first aneurysm. This patient subsequently lost vision and hearing and regained both after steroid therapy. When . . . [Full Text of this Article]






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