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J Thorac Cardiovasc Surg 2007;133:103
© 2007 The American Association for Thoracic Surgery

General Thoracic Surgery

Discussion

Dr Malcolm V. Brock (Baltimore, Md). The authors present an elegant study using a mouse model to investigate the structural mechanics and the dynamic interactions of the pulmonary and bronchial circulations during chronic inflammation of the lungs. Although the bronchial circulation is known to account for less than 5% of the blood supply and to provide nourishment to the central airways, very little is known about the structure of the bronchial microcirculation. So little is known, in fact, that there has not even been a demonstration of the existence of bronchial circulation in the mouse before this report.

The authors’ mouse model has been well validated in some of their previous work and seems to provide a very reliable, reproducible inflammatory response in the lung, with resulting edema and atelectasis, and histologically there is a . . . [Full Text of this Article]

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