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J Thorac Cardiovasc Surg 2007;133:1133-1134
© 2007 The American Association for Thoracic Surgery

Editorial

Five-year cognitive outcomes: Surgical effects or natural progression of vascular disease

John W. Hammon, Jr, MD*, David A. Stump, PhD

Department of Cardiothoracic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Received for publication October 27, 2006; accepted for publication November 2, 2006.

* Address for reprints: John W. Hammon, Jr, MD, Department of Cardiothoracic Surgery, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1096. (Email: jhammon@wfubmc.edu).

The first 20% of the full text of this article appears below.

GoThe article "Neuroprotective effect of mild hypothermia in patients undergoing coronary artery surgery with cardiopulmonary bypass: Five-year follow-up of a randomized trial," published in this issue,1Go is a follow-up to an excellent article written by the same authors in 2001,2Go which demonstrated that mild hypothermia applied to patients undergoing coronary artery bypass grafting (CABG) for the entire operative course has a significant protective effect against early neurocognitive deficits. Mild hypothermia was the subject of another article from this group as being associated with better short-term outcomes.3Go These studies and others point out a very important adjunct in treating patients on cardiopulmonary bypass with coronary disease.

The proposed mechanism of action is the reduction in the brain’s metabolic rate and concomitant decrease in brain blood flow. Less brain blood flow reduces the potential embolic load. Hypothermia also reduces the volume of ischemic tissue undergoing necrosis or apoptosis.

In the present article, the authors sought to prove that the protective effect of hypothermia lasted . . . [Full Text of this Article]


Related Article

Neuroprotective effect of mild hypothermia in patients undergoing coronary artery surgery with cardiopulmonary bypass: Five-year follow-up of a randomized trial
Howard J. Nathan, Rosendo Rodriguez, Denise Wozny, Jean-Yves Dupuis, Fraser D. Rubens, Gregory L. Bryson, and George Wells
J. Thorac. Cardiovasc. Surg. 2007 133: 1206-1211. [Abstract] [Full Text] [PDF]





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