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J Thorac Cardiovasc Surg 2007;133:1373-1374
© 2007 The American Association for Thoracic Surgery

Brief Communication

Postconditioning in cardiac surgery for tetralogy of Fallot

Department of Cardiothoracic Surgery, Xiang Ya Hospital, Central South University, Changsha, Hunan, P.R. China.

Received for publication January 7, 2007; accepted for publication January 17, 2007.

^_* Address for reprints: Luo Wanjun, MD, Department of Cardiothoracic Surgery, Xiang Ya Hospital, Changsha, Hunan, 410008, P.R. China. (Email: luowanjun@yahoo.com).

The first 20% of the full text of this article appears below.

Dr Luo

Postconditioning (POC) performed in brief episodes just at the time of ischemic reperfusion can reduce myocardial injury.^1,2 However, the efficacy of POC in cardiac surgery remains to be determined. We investigated the effect of POC on myocardial protection in children undergoing cardiac surgery for tetralogy of Fallot (TOF).

Patients and Methods

The hospital ethics committee approved this study, and written informed consent was obtained from all patients’ parents. Twenty-four patients aged 1 to 17 years old with TOF were randomized into a POC group (n = 12, female/male ratio: 5/7) and a control group (n = 12, female/male ratio: 4/8). The TOF with pulmonary atresia and absent pulmonary valve were exclusive. Anesthesia was similar in both groups. The operations were performed by the same surgeon (Dr Luo), using hypothermic cardiopulmonary bypass (28°C-30°C) with a hollow-fiber oxygenator and aprotinin (5 x 10⁵ U/kg) administered to the priming volume. The myocardium was protected using intermittent antegrade perfusion of cold blood cardioplegic solution (St Thomas Hospital) in a ratio of 1:4.

POC was started . . . [Full Text of this Article]

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