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J Thorac Cardiovasc Surg 2007;133:1387-1388
© 2007 The American Association for Thoracic Surgery

Brief Communication

Lung fibrosis as a potential complication of the hemostatic tissue sealant, biologic glue (Bioglue)

Saleem Haj-Yahia, MD, BSca,c,*, Tarun Mittal, MD, FRCRb, Emma Birks, MRCP, PhDa, Martin Carby, MRCPa, Mario Petrou, FRCS, PhDa, John Pepper, FRCSa, Gilles Dreyfus, MD, PhDa, Mohammed Amrani, MD, PhDa

a Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield Hospital, NHS Trust, London, UK
b Department of Radiology, Royal Brompton & Harefield Hospital, NHS Trust, London, UK
c National Heart & Lung Institute, Imperial College London, London, UK

Received for publication October 6, 2006; accepted for publication November 28, 2006.

* Address for reprints: Saleem Haj-Yahia, MD, BSc, Royal Brompton & Harefield NHS trust, Cardiothoracic Transplantation and Mechanical Circulatory Support, Hill End Road Harefield, London UB9 6RJ, UK. (Email: s.haj-yahia@imperial.ac.uk).

The first 20% of the full text of this article appears below.

Surgical use of the hemostatic tissue sealant Bioglue has become a widely accepted and effective method to control postoperative bleeding and airway air leak (AAL).1,2Go However, recently emerging evidence of potential complications and hazards that arise from its extensive use has raised concerns about its clinical safety.3Go

Clinical Summary

A 27-year-old woman with acute viral myocarditis had severe heart failure, sepsis, multiorgan failure, and acute hemodynamic deterioration despite maximum medical therapy. A salvage Levitronix left ventricular assist device (LVAD) was urgently implanted as a "bridge to decision" until the reversibility of her condition could be clarified. However, due to poor right ventricular functioning, a Centrimag (Levitronix, Zurich, Switzerland) right ventricular assist device (RVAD) had to be implanted 3 days later. Following an apparently good recovery after 2 weeks, the Levitronix LVAD was upgraded to a Jarvik 2000 ventricular assist device (Jarvik Heart, Inc, New York, NY) for longer-term support; the RVAD was left in place due to poor right ventricular function. The initial postoperative course was turbulent, complicated by 2 sternal reexplorations for significant diffuse bleeding . . . [Full Text of this Article]




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