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J Thorac Cardiovasc Surg 2007;133:1685-1686
© 2007 The American Association for Thoracic Surgery

Letter to the Editor

High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine: Relevance to the human situation?

Frauke S. Czepluch, MD, Johannes Waltenberger, MD, PhD

Department of Cardiology, University of Maastricht, Maastricht, The Netherlands

The first 20% of the full text of this article appears below.

To the Editor:

We read with great interest the article by Boodhwani and colleagues1Go regarding the impact of high-dose statin therapy on vascular endothelial growth factor-A (VEGF-A)–induced myocardial angiogenesis in a hypercholesterolemic pig model of chronic ischemia. This article demonstrated that collateral-dependent myocardial perfusion remained impaired in hypercholesterolemic and atorvastatin-treated pigs in response to additional treatment with VEGF-A relative to a normocholesterolemic control group. It concluded that a high-dose statin therapy was not associated with improved myocardial neovascularization. In that study, however, the hypercholesterolemic pigs . . . [Full Text of this Article]


Related Article

Reply to the Editor
Munir Boodhwani and Frank W. Sellke
J. Thorac. Cardiovasc. Surg. 2007 133: 1686-1687. [Extract] [Full Text] [PDF]





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