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J Thorac Cardiovasc Surg 2007;134:271
© 2007 The American Association for Thoracic Surgery

Letter to the Editor

Amiodarone and cardiac surgery

J. Scott Rankin, MD

Centennial Medical Center, Vanderbilt University, Nashville, Tenn

The first 20% of the full text of this article appears below.

To the Editor:

The recent publication of a large randomized trial of amiodarone arrhythmia prophylaxis after cardiac surgery (PAPABEAR) is of great interest.1Go It was striking how similar the results of this trial were to our previous observational analysis of perioperative amiodarone during mitral valve repair,2Go and a detailed comparison raises several points. First, both studies concluded that amiodarone was effective, reducing postoperative atrial arrhythmias by half and virtually eliminating mortality from ventricular arrhythmias. Second, serious complications of a brief perioperative administration were rare. In PAPABEAR, bradycardia requiring dose reduction occurred in 5.7% of cases and was considered a side effect. In . . . [Full Text of this Article]




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[Abstract] [Full Text] [PDF]


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