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J Thorac Cardiovasc Surg 2007;134:504-505
© 2007 The American Association for Thoracic Surgery

Brief Communication

A randomized trial of an external Dacron sheath for the prevention of vein graft disease: The Extent study

Gavin J. Murphy, MD, FRCS*, Andrew C. Newby, BA, PhD1, Jamie Y. Jeremy, PhD, Andreas Baumbach, MD, FRCP, Gianni D. Angelini, MD, FRCS1

Bristol Heart Institute, Bristol Royal Infirmary, Bristol, United Kingdom.

* Address for reprints: Mr GJ Murphy, Bristol Heart Institute, Bristol Royal Infirmary, Marlborough Street, Bristol BS6 5SJ, United Kingdom. Telephone: 0044 117928 3145, Fax: 0044 1179299737. (Email: Gavin.Murphy@bristol.ac.uk).

The first 20% of the full text of this article appears below.

The success of coronary artery bypass grafting is limited by poor long-term graft patency. Despite the superior patency of arterial grafts, saphenous vein remains the most commonly used conduit for coronary artery bypass because of its predictable handling qualities and ready availability.1Go Over 40% of vein grafts are thrombosed at 10 years postoperatively,2Go largely as a consequence of vein graft disease that is characterized by neointima formation, atherosclerosis, and plaque rupture. Graft failure results in recurrent angina, myocardial infarction, or death and leads to repeat revascularization procedures with their associated morbidity and costs. To date, with the exception of aggressive lipid lowering, no therapy has been shown to improve long-term vein graft patency in clinical studies. In porcine saphenous vein to carotid artery interposition graft, placement of a loose-fitting external macroporous Dacron sheath inhibits vein graft disease in the long term.3,4Go The aim of this phase I randomized pilot study was to evaluate the effects of placement of the external Dacron stent, or . . . [Full Text of this Article]




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Home page
 Circ Cardiovasc IntervHome page
T. Rajathurai, S. I. Rizvi, H. Lin, G. D. Angelini, A. C. Newby, and G. J. Murphy
Periadventitial Rapamycin-Eluting Microbeads Promote Vein Graft Disease in Long-Term Pig Vein-Into-Artery Interposition Grafts
Circ Cardiovasc Interv, April 1, 2010; 3(2): 157 - 165.
[Abstract] [Full Text] [PDF]


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