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J Thorac Cardiovasc Surg 2007;134:808-809
© 2007 The American Association for Thoracic Surgery
Brief Communication |
a Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
b Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
c University of Milan School of Medicine, Milan, Italy.
Received for publication May 22, 2007; accepted for publication May 31, 2007. * Address for reprints: Domenico Galetta, MD, Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy. (Email: mimgaletta@yahoo.it).
| The first 20% of the full text of this article appears below. |
Synovial sarcoma is a malignant neoplasm predominantly affecting soft tissues of the extremities in adolescents and young adults and might rarely occur in other anatomic locations. The lung, mediastinum, pleura, and chest wall have also recently been found to be sites affected primarily by this sarcoma.1-3
We evaluated the clinical and pathologic features of primary synovial sarcoma (PSS) of the chest and the role of surgical intervention and tried to identify possible prognostic factors affecting survival.
Clinical Summary
Between October 1998 and December 2006, 15 patients (7 men) underwent a resection of PSSs of the chest, which were categorized into pulmonary, mediastinal, and chest wall PSSs according to the tumor location. Medical records of these patients were analyzed for age, sex, preoperative symptoms, radiologic findings, pathology, surgical procedures, clinical outcome, and long-term survival.
All pathologic slides were rereviewed, and PSSs were confirmed by means of immunohistochemical and fluorescence in situ hybridization studies. Fluorescence in situ hybridization analysis was performed for the identification of the diagnostic chromosomal translocation (t[X;18][p11.2;q11.2]), a marker for this tumor, resulting from fusion of the SYT
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