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J Thorac Cardiovasc Surg 2007;134:1376-1378
© 2007 The American Association for Thoracic Surgery

Brief Communication

Four thymus-related syndromes in a case of invasive thymoma

^a Division of Thoracic Surgery, Department of Cardiac and Thoracic Surgery, University of Pisa, Pisa, Italy
^b Division of Neurology, University of Pisa, Pisa, Italy.

Received for publication May 3, 2007; accepted for publication July 9, 2007.

^_* Address for reprints: Marco Lucchi, MD, Division of Thoracic Surgery, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. (Email: m.lucchi@med.unipi.it).

The first 20% of the full text of this article appears below.

Thymoma is an epithelial tumor that is frequently associated with autoimmune phenomena and paraneoplastic syndromes. The most frequent are neuromuscular¹ and hematologic² disorders; however, neurologic,³ dermatologic,⁴ ophthalmologic, and other disorders are reported.⁵ The surgical resection of the tumor and associated adjuvant therapies often result in an improvement or complete remission of the symptoms. On the other hand, a thymus-related syndrome sometimes develops months or years after the treatment of the thymoma.¹ Moreover, the recurrence of thymoma may be accompanied by recurrence of the originally associated paraneoplastic syndrome, even after many years.

The association of 2 or more paraneoplastic syndromes is rare in any case. We report a unique case of invasive thymoma and 4 thymus-related syndromes occurring in the preoperative setting.

Clinical Summary

A 43-year-old man with recurrent fever and limb petechiae was admitted to the internal medicine division of our hospital. Serum platelet count was 16 x 10³/µL, red cell count was 2.9 x 10⁶/µL, and hemoglobin concentration was 8.2 g/dL. The diagnosis of pure red cell aplasia and idiopathic thrombocytopenic purpura was made.

The marrow biopsy showed 1) a well-represented granuloblastic group . . . [Full Text of this Article]

This article has been cited by other articles:

				M. Lucchi, F. Basolo, and A. Mussi Surgical treatment of pleural recurrence from thymoma Eur J Cardiothorac Surg, April 1, 2008; 33(4): 707 - 711. [Abstract] [Full Text] [PDF]