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J Thorac Cardiovasc Surg 2007;134:1381-1382
© 2007 The American Association for Thoracic Surgery

Letter to the Editor

The conduct of experimental circulatory arrest: The search for clinical relevance

John G.T. Augoustides, MD, FASE

Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, Pa

The first 20% of the full text of this article appears below.

To the Editor:

I read with great interest the excellent laboratory study by Dr Ananiadou and colleagues1Go detailing the neuroprotective effect of profound hypothermia at 10°C after 75 minutes of circulatory arrest in an acute porcine model (N = 12). The described neuroprotective mechanism may involve antiapoptotic effects. The discussion about this study focused on the neuroprotective balance between the degree of hypothermia and the duration of circulatory arrest.1Go

An important consideration is that the 75-minute duration of circulatory arrest in this animal . . . [Full Text of this Article]


Related Article

Reply to the Editor
Elizabeth O. Johnson and Olga Ananiadou
J. Thorac. Cardiovasc. Surg. 2007 134: 1382-1383. [Extract] [Full Text] [PDF]





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