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J Thorac Cardiovasc Surg 2008;135:210-211
© 2008 The American Association for Thoracic Surgery

Brief Communication

What happens after pneumonectomy? A prospective study using the transpulmonary thermodilution method

^a Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
^b Department of Anesthesia and ICU, European Institute of Oncology, Milan, Italy
^c School of Medicine, University of Milan, Italy.

Received for publication July 29, 2007; accepted for publication August 30, 2007.

^_* Address for reprints: Francesco Leo, MD, PhD, Thoracic Surgery Department, European Institute of Oncology, Via Ripamonti 435, 20100 Milan, Italy. (Email: francesco.leo@ieo.it).

The first 20% of the full text of this article appears below.

After pneumonectomy, several factors may facilitate the occurrence of pulmonary edema, such as right ventricular performance, which is usually impaired after major lung resections,¹ and fluid overload.² The common final event is the augmentation of the extravascular lung water (EVLW) that transudates into the alveolar space, impairing ventilation.

In the experimental model, thoracotomy, rapid fluid infusion, and manipulation of the lung result in an increase in EVLW.³ In humans, the transpulmonary thermodilution method is a reliable technique for EVLW assessment, even if a moderate overestimation as compared with the double-indicator method is expected in case of pneumonectomy.⁴ Given the paucity of available information, this study was designed to monitor EVLW modifications occurring early after pneumonectomy in humans.

Patients and Methods

The aim of the study was to monitor pulmonary and cardiac modifications after pneumonectomy by the transpulmonary thermodilution method using the PiCCO System (Pulsion Medical Systems, Munich, Germany).

The population was represented by 15 consecutive patients with lung cancer undergoing pneumonectomy at the Thoracic Surgery Department of the European Institute of Oncology.

Transpulmonary Thermodilution Method

. . . [Full Text of this Article]

This article has been cited by other articles:

				F. Leo, P. Scanagatta, F. Vannucci, D. Brambilla, D. Radice, and L. Spaggiari Impaired quality of life after pneumonectomy: Who is at risk? J. Thorac. Cardiovasc. Surg., January 1, 2010; 139(1): 49 - 52. [Abstract] [Full Text] [PDF]