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J Thorac Cardiovasc Surg 2008;135:947-948
© 2008 The American Association for Thoracic Surgery

Brief Communication

Detection and duration of aspirin resistance after coronary artery bypass grafting

^a Federal Institute for Drugs and Medical Devices, Bonn, Germany
^b Department of Thoracic and Cardiovascular Surgery, Heinrich Heine—University Düsseldorf, Düsseldorf, Germany
^c Department of Hemostasis and Transfusion Medicine, Heinrich Heine—University Düsseldorf, Düsseldorf, Germany
^d Department of Pharmacology and Clinical Pharmacology, Heinrich Heine—University Düsseldorf, Düsseldorf, Germany

Received for publication September 3, 2007; accepted for publication November 15, 2007.

^_* Address for reprints: Norbert Zimmermann, MD, Federal Institute for Drugs and Medical Devices, Kurt Georg Kiesinger Allee, D-53175 Bonn, Germany. (Email: nzimmermann@bfarm.de).

The first 20% of the full text of this article appears below.

Aspirin resistance is associated with a significant increase in major adverse cardiovascular events.^1,2 We have previously reported an insufficient antiplatelet effect of aspirin in most patients after coronary artery bypass grafting (CABG).³ Nevertheless, the duration of aspirin resistance after CABG remains unknown, and the suitability of available tools to discriminate those with reduced response to aspirin is controversial. This work determined the antiplatelet effect of aspirin at the time of CABG and 6 months later and examined the reliability of different methods for the diagnosis of aspirin resistance.

Materials and Methods

Subjects and Drug Administration
This study was conducted in agreement with the Declaration of Helsinki and was approved by the institutional ethics committee. Twenty-five consecutive patients undergoing elective CABG for stable three-vessel disease were included. Informed consent was obtained from each participant. Drugs affecting hemostasis had been discontinued at least 10 days before surgery. Starting on day 1 after CABG, 100 mg aspirin (Aspirin 100; Bayer AG, Leverkusen, Germany) was administered every morning.

Measurement of Platelet Function
The following parameters were determined: platelet counts (automated counting), arachidonic . . . [Full Text of this Article]

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