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J Thorac Cardiovasc Surg 2008;135:1245-1246
© 2008 The American Association for Thoracic Surgery

Invited Commentary

Discussion

Dr Robert Poston (Baltimore, Md). Why does sirolimus affect endothelialization in stents but not in your grafts? What is the difference there? It is pretty well known that sirolimus reduces re-endothelialization on top of an intracoronary stent, but it did appear to have the same affect on the conduits in your research.

Dr Ishii. Regarding the endothelialization, in the SEM variations we can see it occurring beautifully inside the graft wall. When compared with a non-sirolimus graft, sirolimus might therefore facilitate good endothelialization. However, although both heparin and heparin-sirolimus grafts had a 100% patency rate during the 6 months after surgery, the heparin-sirolimus grafts showed less . . . [Full Text of this Article]

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A novel bioengineered small-caliber vascular graft incorporating heparin and sirolimus: Excellent 6-month patency

Yosuke Ishii, Shun-ichiro Sakamoto, Russell T. Kronengold, Renu Virmani, Elias A. Rivera, Scott M. Goldman, Ericka J. Prechtel, James G. Hill, and Ralph J. Damiano, Jr.
J. Thorac. Cardiovasc. Surg. 2008 135: 1237-1246. [Abstract] [Full Text] [PDF]