J Thorac Cardiovasc Surg 2008;136:225-227
© 2008 The American Association for Thoracic Surgery
Teratoma with malignant transformation in the anterior mediastinum
Katsuhiko Shimizu, MD, PhDa,*,
Masao Nakata, MD, PhDa,
Yuji Hirami, MD, PhDa,
Takashi Akiyama, MD, PhDb,
Kazuo Tanemoto, MD, PhDa
a Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kurashiki, Japan
b Division of Pathology, Kawasaki Medical School, Kurashiki, Japan
Received for publication October 26, 2007; revisions received January 4, 2008; accepted for publication January 6, 2008.
* Address for reprints: Katsuhiko Shimizu, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan. (Email: kshimizu@med.kawasaki-m.ac.jp).
| The first 20% of the full text of this article appears below. |
Malignant transformation of teratoma in the mediastinum is rare. Pathologically, malignant teratoma can be divided into three types: immature teratoma, teratoma with other malignant germ cell tumor components (such as yolk sac tumor, embryonal carcinoma, choriocarcinoma, and seminoma), and teratoma with malignant transformation (TMT).1,2
TMT is a non–germ cell malignant tumor arising from a preexisting mature teratoma. To our knowledge of the literature, TMT in the mediastinum is extremely rare.3,4 This report describes a surgical case of adenocarcinoma arising from a mature, cystic teratoma in the anterior mediastinum.
Clinical Summary
A 43-year-old woman was admitted to the hospital with a mediastinal mass. Eight years previously, she had undergone a medical workup for this mediastinal mass but had refused to heed the recommendation of surgery. At this later admission, she reported a 3-month history of exertional breathlessness. Chest radiography showed a large mass shadow from the mediastinum to the left thoracic cavity; the mass had clearly enlarged relative to its . . . [Full Text of this Article]
Copyright © 2008 by The American Association for Thoracic Surgery.
