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J Thorac Cardiovasc Surg 2008;136:797-798
© 2008 The American Association for Thoracic Surgery

Letter to the Editor

Cardiac stem cells in the real world

Remco Koninckx, MSc, Karen Hensen, PhD, Jean-Luc Rummens, MD, Marc Hendrikx, MD

Virga Jesse Hospital, Hasselt, Belgium and University of Hasselt, Diepenbeek, Belgium

The first 20% of the full text of this article appears below.

To the Editor:

We read with great interest the recent article by Pouly and colleagues.1Go These authors suggest that c-kit+ cells retrieved out of human endomyocardial biopsies do not express the classic markers of stemness but are actually mast cells. By immunofluorescent staining on paraffin slices they show that c-kit+ cells are CD45+ and CD105–. Furthermore they found that these c-kit+ cells also coexpress tryptase, a granule-derived serine proteinase, and as a consequence appear to be mast cells.

In our experiments, right atrial appendages were removed during routine cardiac . . . [Full Text of this Article]






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