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J Thorac Cardiovasc Surg 2009;137:e12-e14
© 2009 The American Association for Thoracic Surgery

Brief Communication

Concomitant cardiac and cerebral leiomyosarcoma: A challenge for surgical and adjuvant therapy

Christoph A. Tschan, MDa, M. Javad Mirzayan, MDa, Alexandru C. Stan, MDb, Maximilian A. Pichlmaier, MDc, Joachim K. Krauss, MDa,*

a Department of Neurosurgery, Hannover Medical School, Hannover, Germany
b Institute of Pathology, Hannover Medical School, Hannover, Germany
c Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany

Received for publication April 8, 2008; revisions received May 8, 2008; accepted for publication May 21, 2008.

* Address for reprints: Joachim K. Krauss, MD, Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany. (Email: Krauss.Joachim@mh-hannover.de).

The first 20% of the full text of this article appears below.

Primary sarcomas of the heart are rare,1Go and features of leiomyosarcoma are present in only 1% to 9%.2Go Although cardiac tumors, such as myxomas, occasionally can metastasize to the brain, this scenario is uncommon for leiomyosarcoma. Only 3 patients with leiomyosarcoma of the heart metastasizing to the brain have been reported within the past 40 years.3-5Go Here we report on a patient with the concomitant occurrence of a cerebral leiomyosarcoma and a cardiac leiomyosarcoma presenting initially with a generalized seizure. This is the first description of a patient in whom a cardiac leiomyosarcoma was detected only after diagnosis of the cerebral tumor.

Clinical Summary

A 35-year-old man presented with a generalized seizure. A cranial magnetic resonance scan showed a large cystic right frontal tumor (Figure 1, A and B). Diagnostic work-up raised the suspicion of a cardiac tumor. Magnetic resonance scans of the chest (Figure 1, C and D) revealed an intracardiac neoplasm. Coronary angiographic and electrocardiographic analyses were without pathologic findings. Computed tomographic scanning of . . . [Full Text of this Article]






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