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J Thorac Cardiovasc Surg 2009;137:e6-e9
© 2009 The American Association for Thoracic Surgery

Brief Communication

Do statins delay the progression of aortic stenosis?

Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan

Received for publication March 4, 2008; accepted for publication March 14, 2008.

^_* Address for reprints: Hisato Takagi, MD, PhD, Department of Cardiovascular Surgery, Shizuoka Medical Center, 762–1 Nagasawa, Shimizu-cho, Sunto-gun, Shizuoka 411–8611, Japan. (Email: kfgth973@ybb.ne.jp).

The first 20% of the full text of this article appears below.

Calcific aortic stenosis (AS) is the most common form of valvular heart disease in the Western world, and the only established therapy for patients with severe symptomatic AS is surgical valve replacement. There are currently no effective disease-modifying treatments, and the possibility of halting the disease process would represent a therapeutic advance.¹ Although some observational studies^2-4 demonstrated that statins (hydroxymethylglutaryl-coenzyme A reductase inhibitors) delayed the progression of AS, a randomized controlled trial¹ concluded that intensive lipid-lowering therapy with atorvastatin did not halt its progression. Furthermore, no meta-analysis of studies of statins for AS has been conducted to date. Therefore, the appropriate role of statins for AS remains unclear. We performed a meta-analysis of comparative studies of statins for the prevention of the progression of AS.

Clinical Summary

All comparative studies of statins versus control (no statins or placebo) for AS were identified using a 2-level search strategy. First, a public domain database (MEDLINE) was searched using . . . [Full Text of this Article]

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				E. W. Kuhn, O. J. Liakopoulos, Y. H. Choi, and T. Wahlers Current Evidence for Perioperative Statins in Cardiac Surgery Ann. Thorac. Surg., July 1, 2011; 92(1): 372 - 379. [Abstract] [Full Text] [PDF]

				D. Vedamurthy, J. Molnar, and R. Arora Aortic stenosis and statins. J. Thorac. Cardiovasc. Surg., November 1, 2009; 138(5): 1254 - 1255. [Full Text] [PDF]

				H. Takagi and T. Umemoto Reply to the editor. J. Thorac. Cardiovasc. Surg., November 1, 2009; 138(5): 1255 - 1255. [Full Text] [PDF]