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Tadashi Ikeda
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J Thorac Cardiovasc Surg 2009;137:783-784
© 2009 The American Association for Thoracic Surgery

Brief Communication

A potential of autologous pericardium for a sustained-release carrier of vancomycin: A pilot study in vitro

Akira Marui, MD, PhDa, Keiichi Hirose, MD, PhDa, Hisashi Sakaguchi, MDa, Yoshio Arai, MD, PhDa, Kazuhiko Doi, MD, PhDb, Masaki Tsukashita, MDa, Takeshi Shimamoto, MDa, Tadashi Ikeda, MD, PhDa, Masashi Komeda, MD, PhDa,*

a Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
b Department of Cardiovascular Surgery, Takeda Hospital, Kyoto, Japan

Received for publication December 9, 2007; revisions received January 18, 2008; accepted for publication February 4, 2008.

* Address for reprints: Masashi Komeda, MD, PhD, Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawahara, Sakyo, Kyoto, 606-8507 Japan. (Email: komelab@kuhp.kyoto-u.ac.jp).

The first 20% of the full text of this article appears below.

Autologous pericardium has been widely used to repair destructed annuli in infective endocarditis complicated by annular abscess.1,2Go In the present study we investigated the in vitro property of autologous pericardium for a sustained-release carrier of vancomycin.

Clinical Summary

Between January and May 2002, autologous pericardium with pericardial fat was harvested from the patients (n = 6) who underwent cardiac operations in our institute. After harvesting, the pericardium was cut into 7 pieces (1 cm x 1 cm each). Then 0.2 mL of vancomycin solution (15 mg/mL) was dropped onto each pericardium and incubated for 1 hour at room temperature so that the vancomycin solution was completely absorbed into the pericardium. The 7 pericardial patches with vancomycin were soaked in 7 test tubes containing 5 mL of saline, respectively. The test tubes were placed in the shaker and kept at 37°C. At 6 hours, 12 hours, and 1, 3, 5, 7, and 10 days after the incubation, the pericardium and the . . . [Full Text of this Article]






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