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J Thorac Cardiovasc Surg 2009;137:1556-1557
© 2009 The American Association for Thoracic Surgery

Brief Communication

Early stenosis of Medtronic Mosaic porcine valves in the aortic position

Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Mo

Received for publication June 2, 2008; accepted for publication June 8, 2008.

^_* Address for reprints: Jennifer S. Lawton, MD, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8234, St Louis, MO 63110. (Email: lawtonj@wustl.edu).

The first 20% of the full text of this article appears below.

The third-generation Medtronic Mosaic porcine bioprosthesis (Medtronic Inc, Minneapolis, Minn) was introduced in 1994. The valve leaflets are fixed in glutaraldehyde at zero pressure (applying equal pressure to the inflow and outflow ends of the valve), the root is dilated to a pressure of 40 mm Hg ("physiologic fixation"), the fixed tissue is treated with -aminooleic acid (a long-chain fatty acid that binds to the aldehyde fractions of the glutaraldehyde-preserved porcine tissue) to reduce calcification, and the tissue is mounted on a Hancock II (Medtronic Inc) flexible stent made of acetyl copolymer covered with Dacron fabric.^1,2

Clinical Summary

The Medtronic Mosaic porcine valve has been reported to be both reliable and durable over time.^1-4 The alarmingly early stenosis of an implanted Medtronic Mosaic . . . [Full Text of this Article]

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