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J Thorac Cardiovasc Surg 2009;137:1573
© 2009 The American Association for Thoracic Surgery

Letter to the Editor

Experimental ventricular pressure overload in young animals induces cardiomyocyte hypertrophy in addition to hyperplasia of contractile and noncontractile elements of the myocardium

^a Laboratory of Echocardiography, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
^b Division of Surgical Research, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
^c Laboratory of Pathology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil

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To the Editor:

Since the early 1990s, we have been working with experimental right ventricular hypertrophy using young goats aged 4 to 8 weeks to achieve right (subpulmonary) ventricular retraining by means of a balloon catheter or an adjustable pulmonary artery banding system.^1-3 We have consistently found a hypertrophic response of the cardiomyocytes. Moreover, we have also demonstrated that the right ventricle responds not only . . . [Full Text of this Article]