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J Thorac Cardiovasc Surg 2009;138:257
© 2009 The American Association for Thoracic Surgery

Letter to the Editor

Hypoxia-inducible factor-1{alpha} in stem cell preconditioning: Mechanistic role of hypoxia-related micro-RNAs

Khawaja Husnain Haider, MPharm, PhD, Ha Won Kim, PhD, Muhammad Ashraf, PhD

Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio

The first 20% of the full text of this article appears below.

To the Editor:

Since its inception more than 2 decades ago, ischemic preconditioning (IP) is considered as the most powerful cytoprotective stimulus and is being devised as a potent strategy to promote stem cell survival post-engraftment in the infarcted heart.1Go The elegant study from Hu and colleagues2Go is a step forward toward the use of low oxygen culture conditions to trigger activation of survival signaling pathways in the cells before their engraftment in vivo. The authors showed significantly improved survival of the hypoxia-treated (0.5% oxygen for 24 hours) mesenchymal stem cells after engraftment in the infarcted heart. . . . [Full Text of this Article]


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Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis
Xinyang Hu, Shan Ping Yu, Jamie L. Fraser, Zhongyang Lu, Molly E. Ogle, Jian-An Wang, and Ling Wei
J. Thorac. Cardiovasc. Surg. 2008 135: 799-808. [Abstract] [Full Text] [PDF]





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