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J Thorac Cardiovasc Surg 2009;138:262
© 2009 The American Association for Thoracic Surgery

Letter to the Editor

Mechanism of myocardial protection by pressure-volume unloading involves stretch-induced pathophysiology

Alfred C. Nicolosi, MD

Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wis

The first 20% of the full text of this article appears below.

To the Editor:

I read with interest the recent report by Tamareille and colleagues,1Go who demonstrate in a porcine model of myocardial infarction that left ventricular (LV) unloading with a left ventricular assist device (LVAD) during early reperfusion is associated with both reduced endothelin-1 release by the myocardium and reduced infarct size. They demonstrate a positive . . . [Full Text of this Article]


Related Article

Left ventricular unloading before reperfusion reduces endothelin-1 release and calcium overload in porcine myocardial infarction
Sophie Tamareille, Hela Achour, James Amirian, Patricia Felli, Roger J. Bick, Brian Poindexter, Yong J. Geng, William H. Barry, and Richard W. Smalling
J. Thorac. Cardiovasc. Surg. 2008 136: 343-351. [Abstract] [Full Text] [PDF]





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