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J Thorac Cardiovasc Surg 2009;138:592-593
© 2009 The American Association for Thoracic Surgery

Invited Commentary

Discussion

Dr Sebastien Gilbert (Pittsburgh, Pa). First, I would like to congratulate you and your team for your contribution to the exciting field of airway replacement and regeneration.

I have 3 questions. First, in addition to uniaxial loading, have you looked at the pressure-diameter response of the grafts or the ability of the graft to withstand negative intraluminal pressure without collapsing?

Dr Jungebluth. That is a very interesting point. We have not done it until now but are currently in the process of doing so.

Dr Gilbert. Second, what effect, if any, does the 35-day, 17-cycle detergent preparation have on the collagen fiber integrity and the glycosaminoglycan content of the extracellular matrix of the trachea?

Dr Jungebluth. Actually, we did not check it immediately, but the mechanical strain test showed that this quiet and soft and gentle treatment actually did not have a strong effect on the mechanical properties of this tracheal matrix if you just continued under 17 cycles, but I guess it is a critical point that if you continue above 17 cycles, then . . . [Full Text of this Article]