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J Thorac Cardiovasc Surg 2009;138:793-794
© 2009 The American Association for Thoracic Surgery

Letter to the Editor

Reply to the Editor

Barnaby C. Reeves, DPhil, Gianni D. Angelini, MD, FETCS

Bristol Heart Institute, Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol, United Kingdom

The first 20% of the full text of this article appears below.

In this issue, Takagi and Umemoto1Go report a meta-analysis of patency after coronary artery bypass (CABG) and off-pump CABG (OPCAB) that we and others declined to conduct.2,3Go We have 4 comments on the appropriateness of both their revised and original analyses.4Go

The authors make the mistake that we described in our article3Go—that is, they assumed statistical independence of multiple grafts in the same patients. We reiterate that this "could seriously undermine statistical inferences."3Go In our own primary patency analysis, ignoring the dependency between grafts within patients would have narrowed the confidence interval by 40%. Underestimating the standard errors by this amount would make all of their pooled . . . [Full Text of this Article]


Related Article

Graft patency in coronary artery bypass versus off-pump coronary artery bypass
Hisato Takagi and Takuya Umemoto
J. Thorac. Cardiovasc. Surg. 2009 138: 792-793. [Extract] [Full Text] [PDF]





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