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J Thorac Cardiovasc Surg 2003;126:252-253
© 2003 The American Association for Thoracic Surgery

Surgery for congenital heart disease

Discussion

The first 20% of the full text of this article appears below.

Dr John E. Mayer, Jr (Boston, Mass). First let me congratulate Hawkins and colleagues on a clear presentation of important work. The finding that decellularized homografts do not elicit the same antibody response as cellular grafts is of significant interest, particularly for patients who ultimately may require transplantation. I have found it interesting from a historical and scientific standpoint how our pendulum has swung from the concept years ago, when we were told that preserving the viability of cells on homografts was critical to their long-term function, to the other end of the spectrum. Now we’re being told that decellularization will actually be a better process.

I have no specific comments about the antigenicity. And in some ways I think that the findings are almost what one would predict. But if one disregards those immunologic considerations, I wondered about a few things.

First, Dr Hawkins, you have shown that the explanted graft of homograft material was cellularized, but we don’t really know what kind of cells they are. In particular, I wondered whether you had any notions about what the cells on the luminal . . . [Full Text of this Article]


Related Article

Immunogenicity of decellularized cryopreserved allografts in pediatric cardiac surgery: comparison with standard cryopreserved allografts
John A. Hawkins, Neal D. Hillman, Linda M. Lambert, Jamison Jones, Gregory B. Di Russo, Tracie Profaizer, Thomas C. Fuller, L. LuAnn Minich, Richard V. Williams, and Robert E. Shaddy
J. Thorac. Cardiovasc. Surg. 2003 126: 247-252. [Abstract] [Full Text] [PDF]





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