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J Thorac Cardiovasc Surg 2007;133:426-427
© 2007 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

Discussion

Dr Sahar Gideon (Beer Sheba, Israel). I would like to know whether you could determine any correlation between intimal hyperplasia and risk factors of these patients?

Dr Burris. We did not look in this particular study at the risk factors for intimal hyperplasia. We analyzed discarded segments of these conduits that were given to us after bypass surgery. The primary thrust of this study was really to validate OCT’s accuracy and reproducibility as an evaluation tool. However, those are definitely questions that we are interested in pursuing and will be pursuing in the future. We are interested in the pathological significance of these pre-existing pathologies and how they relate to patency. I think we have demonstrated that OCT has the ability to detect these pathologies, which will be the first step in understanding their physiological importance.

Dr Gideon. Do you have any information about the ITA?

Dr Burris. Yes. Excellent question. Thank you. It is well known that the ITA is the best conduit for bypass surgery. It is typically harder to get a discarded segment to scan, but on several occasions, we have observed 4 discarded segments of distal ITA, and in none of those samples have we noticed any type of plaque, intimal thickening, or any other pathology that is detectable with OCT. These findings suggest the relative health of ITAs and also corroborate our histologic findings that there is excellent endothelial integrity and low disease in the ITA.

Dr Hakob . . . [Full Text of this Article]

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