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J Thorac Cardiovasc Surg 2007;133:1036
© 2007 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

Discussion

The first 20% of the full text of this article appears below.

Dr John A. Kern (Charlottesville, Va). John, that was a very nice study that gives us more insight into the molecular biology of ascending aortic aneurysm pathology. As you detailed in your manuscript, but not so much here because of time constraints, your results really parallel those of others. However, your study goes a bit further in showing us various activity profiles even among aneurysms of different sizes, which is quite interesting.

The main questions I have, to bring this into some clinical appreciation, is what does this study really do in furthering our understanding of the natural history of ascending aortic aneurysms, and will findings such as these ultimately change the way we approach aneurysms, particularly with respect to timing of repair?

I also have a few nuts-and-bolts questions. The patients in the control group were quite a bit younger than those in the other groups, and it makes us wonder about the biology of MMPs in general, so could you just talk a bit about that. Also, your findings may have a genetic basis. Did you see any differences in profiles with respect to gender?

In addition, there is potentially a lot of differing medical therapy in these patients, . . . [Full Text of this Article]


Related Article

Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves
John S. Ikonomidis, Jeffery A. Jones, John R. Barbour, Robert E. Stroud, Leslie L. Clark, Brooke S. Kaplan, Ahmed Zeeshan, Joseph E. Bavaria, Joseph H. Gorman, III, Francis G. Spinale, and Robert C. Gorman
J. Thorac. Cardiovasc. Surg. 2007 133: 1028-1036. [Abstract] [Full Text] [PDF]





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