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J Thorac Cardiovasc Surg 2007;133:1145-1146
© 2007 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology

Discussion

Dr Y. Joseph Woo (Philadelphia, Pa). The authors should be congratulated on a great body of work and, as usual, great graphics from Toronto. Are venous endothelial cells the same as arterial endothelial cells, and are they an adequate surrogate if you are using this as a model for allograft vasculopathy and other sorts of arterial problems?

Dr Danny Ramzy (Toronto, Canada). Thank you for the question. We have actually performed experiments looking at that question. Between human saphenous vein endothelial cells, human aortic endothelial cells, and human coronary endothelial cells, once you pass the first passage, and all experiments are performed beyond P1, they all behave the same way as ET-1 and other vasoconstrictors and soluble factors. So in terms of using saphenous . . . [Full Text of this Article]

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J. Thorac. Cardiovasc. Surg. 2007 133: 1137-1146. [Abstract] [Full Text] [PDF]