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J Thorac Cardiovasc Surg 2007;133:1362-1363
© 2007 The American Association for Thoracic Surgery

Cardiothoracic Transplantation

Discussion

Dr Joseph B. Zwischenberger (Galveston, Tex). As one approaches the problem of an off-the-shelf artificial lung, the spectrum ranges from aplastic artificial lung all the way to transspecies transplant. You are to be congratulated for persisting in your work of trying to accomplish transspecies transplantation, which has the promise for an off-the-shelf artificial lung.

This work has been ongoing for 10 or 15 years, and it strikes me that creating a transgenic knockout swine model is very difficult. You did not mention what it takes to create that. Could you please recap that for us?

Second, I am having some difficulty in trying to put together the accomplishment of a 2-hour survival in two of three pigs. How is two of three an advance?

Finally, you mentioned intravascular coagulation as . . . [Full Text of this Article]

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J. Thorac. Cardiovasc. Surg. 2007 133: 1354-1363. [Abstract] [Full Text] [PDF]