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J Thorac Cardiovasc Surg 2007;134:431-432
© 2007 The American Association for Thoracic Surgery

Evolving Technology

Discussion

Dr Richard D. Weisel (Toronto, Ontario, Canada). If you think that the major difference is related to the fact that the cells were cultured, it is possible that they contained some of the cytokines that were used in the culturing process? I presume that you used fetal bovine serum as one of the cytokines. If the cytokines are the important component here, perhaps you need to seed either the cells or the acellular tissue with cytokines in addition to the cells. What are your thoughts?

Dr Vincentelli. We did not investigate this issue about the cytokines precisely, but this remains a possibility. We focused more on the possibility that the selection of cultured MSCs could limit the inflammatory process owint . . . [Full Text of this Article]

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