J Thorac Cardiovasc Surg 2007;134:980-981
© 2007 The American Association for Thoracic Surgery
Discussion
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Dr Cliff K. Choong
(Cambridge, United Kingdom). Dr Cardoso, congratulations to you and your co-investigators on this study and results. I am glad to see that the good feasibility and safety results that were found in the animal studies that we had performed have been largely translated and reproduced by you and your clinical investigators in this multicenter study. In the animal study that we had performed at Washington University, we had found that 65% of paclitaxel stents were patent at 18 weeks whereas the control stents were all occluded at 4 weeks. This information was presented in 2005 before this Association and published in the January 2006 issue of the Journal of Thoracic and Cardiovascular Surgery. I have always been curious about patency in clinical studies on patients. On the one hand, it may be that ventilation through the airway bypass stents between the airway and the destroyed emphysematous lungs may improve the patency rate, but on the other hand, thick mucus and infection in patients with COPD may accelerate occlusions of the airway bypass stents. Did you and your investigators assess the patency of the airway bypass stents in your patients? If you did, what were the percentage of patency and the duration of patency, and how did . . . [Full Text of this Article]
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J. Thorac. Cardiovasc. Surg. 2007 134: 974-981.
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