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J Thorac Cardiovasc Surg 2008;135:164-165
© 2008 The American Association for Thoracic Surgery

Cardiothoracic Transplantation

Discussion

Dr Mark J. Krasna (Towson, Md). What is the anti-inflammatory effect that you think ATL-313 has? Tell us what your view is.

Dr Gazoni. A_2AR agonists significantly decrease the amount of leukocyte activation and decrease the interaction of neutrophils, for example, with endothelial cells. One of the mechanisms behind that is decreasing the expression of adhesion molecules such as intercellular adhesion molecule and P-selectin. These are some of the few widely documented anti-inflammatory effects of the A_2AR agonists.

Dr Frank W. Sellke (Boston, Mass). . . [Full Text of this Article]

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Additive protection against lung ischemia-reperfusion injury by adenosine A_2A receptor activation before procurement and during reperfusion

Leo M. Gazoni, Victor E. Laubach, Daniel P. Mulloy, A. Bellizzi, Eric B. Unger, Joel Linden, Peter I. Ellman, Turner C. Lisle, and Irving L. Kron
J. Thorac. Cardiovasc. Surg. 2008 135: 156-165. [Abstract] [Full Text] [PDF]