HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miralles, A. Articles by Cabrol, C. Search for Related Content PubMed PubMed Citation Articles by Miralles, A. Articles by Cabrol, C.

J Thorac Cardiovasc Surg 1994;107:184-190
© 1994 Mosby, Inc.

SURGERY FOR ACQUIRED HEART DISEASE

Cardiac echinococcosis: Surgical treatment and results

Paris, France

From the Department of Cardiovascular Surgery, La Pitié Hospital, Paris, France.

Received for publication Nov. 6, 1992. Accepted for publication March 19, 1993. Address for reprints: Albert Miralles, MD, Department of Cardiovascular Surgery, La Pitié Hospital, 83 Bd. de l\'Hôpital 75013 Paris, France.

Abstract

During the last 15 years, eight patients with a diagnosis of hydatid cysts of the heart and one patient with a diagnosis of alveolar hydatid disease with intracardiac parasitic thrombus underwent successful operation at La Pitié Hospital. Only five cases had symptoms, and the remaining four cases were diagnosed incidentally. Serologic tests achieved a variety of results and were not determinant. All patients were examined with echocardiography and angiography, and almost all patients underwent magnetic resonance scanning. Sternotomy was the approach used, and all patients underwent operation with cardiopulmonary bypass. Surgical treatment included puncture and aspiration of the cyst content, previous sterilization with hypertonic saline solution, and excision of the cyst with closure of the cavity in seven patients with different concomitant procedures. No case of intraoperative rupture was reported, and the only complication was an atrioventricular block in a patient with a cyst of the left ventricular wall invading the intreventricular septum. There was no operative mortality, and only one late death was observed. No recurrences or associated complications were reported in the late follow-up. (J THORAC CARDIOVASC SURG 1994;107:184-90)

Hydatid cyst of the heart is an uncommon lesion. ¹ Hydatidosis, a parasitic infection caused by Echinococcus granulosus, is a widely known zoonosis. The life cycle of this cestode/tapeworm involves dogs and other canids as definitive hosts and domestic and wild ungulates, usually sheep, as intermediate hosts. Human beings are only incidental intermediate hosts of this parasitic agent. The infection, often acquired in childhood during play with infected dogs, is most common in the sheep-raising areas of the world.

In human beings, the most frequent locations of the hydatid cysts are the liver (in more than 65% of cases) and the lungs (25%). A mean of only about 0.5% to 2% of cases of hydatid cysts are located in the heart. ¹

Because of the continuous growing of the cysts, the surrounding tissues and cardiac structures become progressively affected, leading to the impairment of the hemodynamic function of the heart. Direct sterilization and surgical excision have been proved to be the best treatment of hydatid cysts of the heart. In this article, we report our clinical and surgical experience on the treatment of the cardiac hydatidosis.

PATIENTS AND METHODS

Between 1971 and 1987, eight patients with hydatid cysts of the heart and one patient with alveolar hydatid disease and parasitic cardiac thrombosis underwent surgical excision at the Department of Cardiovascular Surgery of La Pitié Hospital in Paris, France. There were five male and four female patients, ranging in age from 4 to 63 years with a mean age of 27 ± 17 years. Six of them were born in North Africa.

The diagnoses were incidental in four patients (44.4%), the remaining patients had a variety of symptoms, especially cough and chest pain (Table I).

Chest roentgenograms showed a clear deformation of the medium arch of the cardiac silhouette in most of the cases (77.7%) (Fig. 1). Mediastinic and pulmonary calcifications were also observed in two cases, pulmonary cysts in one case, and images considered as masses of the pulmonary parenchyma in one case.

View larger version (107K): [in this window] [in a new window]   Fig. 1. Bulge on the left border of the heart.

All patients were examined with cardiac echography (Fig. 2) with the following diagnoses: cardiac cysts in four patients (44.4%), tumor of unidentified origin in four patients (44.4%), and the normal echocardiographic characteristics in one patient (11.2%).

View larger version (131K): [in this window] [in a new window]   Fig. 2. Bidimensional echocardiography: intrapericardial mass involving the ventricular wall.

View larger version (71K): [in this window] [in a new window]   Fig. 3. A, Coronary angiography showing the displacement of the coronary arteries without luminal obstruction. B, In a later phase, a circular blush can be observed, clearly depicting the cyst.

View larger version (136K): [in this window] [in a new window]   Fig. 4. Magnetic resonance imaging: axial view showing a multilobed mass of the left ventricle.

View larger version (113K): [in this window] [in a new window]   Fig. 5. Multiple organ involvement is evidenced by magnetic resonance imaging. In a frontal view, a multilobed cyst of the heart is associated with a large hepatic cyst in one of our young patients.

In all cases, the operation was performed with medial sternotomy and cardiopulmonary bypass. Mean cardiopulmonary bypass time was 48 ± 20 minutes ranging between 30 and 77 minutes. In four patients, cysts were removed while the patient underwent induced electrical cardiac fibrillation and mild hypothermia; in the remaining five patients, the excision was done after aortic clamping with moderate hypothermia and cardioplegia.

The site of implantation of the cysts was the left ventricular wall in seven cases, the right ventricular wall in one case, and the right atrium in one case. With the exception of one case in which two cysts were discovered, the cysts were isolated in all patients.

All cysts were systematically sterilized. Complete and rapid sterilization of the cysts was performed by injection or instillation of hypertonic saline solution. After sterilization, cysts were enucleated, and the cavity was closed in seven cases by obliteration, plication, or both (Fig. 6). The cavity was let unclosed in one patient. In only one case was a Dacron patch implantation needed to close a ventricular septal defect created after excision of a left ventricular cyst near the septal wall.

View larger version (292K): [in this window] [in a new window]   Fig. 6. A, After sterilization, the cyst is carefully excised with the surrounding layers. B, The cavity is plicated to reinforce the myocardial wall.

The postoperative course was satisfactory in all nine patients. The only complication was a complete atrioventricular block in one patient with a cyst invading the interventricular septum. No operative mortality occurred, and only one case of late mortality of unknown causes occurred. With a follow-up of 1798 patient/days (total 16,184 days), no recurrences or surgically related complications were found.

DISCUSSION

Cardiac involvement of hydatid cyst is an uncommon lesion if compared with hepatic or pulmonary hydatidosis. The reported prevalence is about 0.5% to 2%. ^{1, 2}

Human echinococcosis is caused most commonly by Echinococcus granulosus. ³ Another type is Echinococcus multilocularis, ⁴ the agent of alveolar hydatid disease. Human beings are only incidental hosts by contamination from contact with animals.

After infection, the embryo usually reaches the myocardium via coronary circulation from the left side of the heart. The cyst is then formed within a period of 1 to 5 years. Myocardial reaction consists of a fibrous adventitial pericyst layer surrounding the laminated membrane. ⁵

A wide variation in age has been reported with this condition, without prevalence for age. Some reports ^{1, 6} indicate that cardiac hydatidosis tends to manifest in individuals over the age of 20 years; however, several cases have been reported in younger patients. In spite of our experience, it seems that a prevalence for infection exists in male patients.

Probably only 10% of cases of hydatidosis have clinical manifestations. ⁷ It is widely known that in cystic hydatid disease, the severity and nature of signs and symptoms are extremely variable and rarely pathognomonic, and different clinical syndromes may be present (Table II).

The disease should be suspected in patients from sheep-raising areas, especially if they have signs of cardiac tumor, or when a chest roentgenogram or echocardiogram reveals a mass in relation with the cardiac silhouette.

The most common manifestation observed is chest pain or precordialgia. In our series we found cough and chest pain in three patients and precordalgia in two others. Two patients had embolism, and two others had congestive heart failure. Other clinical features observed were valvular syndrome with the clinical simulation of a mitral, pulmonary, or tricuspid stenosis or regurgitation ^{8, 9} andischemic syndrome. ¹⁰ The ischemic syndrome is of utmost importance because total obstruction of coronary vessels by the cysts has been reported ^{11, 12} with the need for surgical coronary revascularization. Electrocardiographic changes, such as myocardial infarction, arrhythmias, bundle branch conduction disturbances, and sudden cardiac arrest, have been observed also.

The skin test of Casoni is usually positive for disease in these cases but lacks both sensitivity and specificity. ¹³ Its use has been recently discussed because it can generate the sensitization of the patients. Serologic tests have a higher sensitivity and specificity, but they are positive in only approximately 60% of pulmonary and 90% of hepatic lesions. The most useful tests are latex agglutination test and immunoelectrophoresis. ^{13, 14}

Echocardiography is the method of choice for the diagnosis of cardiac cysts. ¹⁵ Two-dimensional echocardiography allows the differentiation of a cyst from a solid mass. In our series, it was only in one case that the echocardiographic imaging revealed a solid mass that was assumed to be a right atrial myxoma, although at operation the mass turned out to be a larval proliferative lesion of Echinococcus multilocularis.

Nuclear magnetic resonance imaging also provides valuable information for the diagnosis, with clear evaluation of tumor extension and tissue involvement. ¹⁶

We believe, as do other authors, ^17-19 that catheterization and coronary angiography are helpful tools in patients with hydatid cysts of the heart. Ventriculography can be useful to determine the intraventricular location of the cysts. Coronary angiography is the only way to evaluate the coronary vessels, and, in late sequences of angiography, the anatomic site and size of the cyst may be depicted in the myocardium (Fig. 3).

In our experience, seven patients had electrocardiographic alterations compatible with those of subepicardial ischemia and necrosis. Angiocardiography was performed in six patients, showing alterations of the interventricular septum and the right and the left ventricular free walls. In two cases a coronary angiography showed the displacement of coronary artery branches without obstruction. Because some cases of coronary artery obstruction by hydatid cysts have been reported in other series, ^{11, 12} we think that coronary angiography should be performed in all patients in whom cardiac hydatidosis is suspected to determine whether the electrocardiographic changes usually observed represent a direct menace for the myocardium. Regardless of the invasive nature of these techniques, we believe they are very helpful for the operative strategy, allowing the surgeon to carry out better myocardial protection or coronary revascularization if required.

In two patients (one was an 8-year-old child), the surgical excision was performed while the patient was under mild hypothermia and induced electrical fibrillation. In accordance with recent tendencies, we used moderate hypothermia with aortic crossclamping and infusion of cardioplegic solution in the last five patients. We think this technique is safer, one of the reasons being that there is a great variability in the time and type of operation required for excision of cysts, depending on the degree of myocardial involvement. ¹⁷ In some cases, smaller, concomitant cysts can be discovered during operation, which leads to the prolongation of both the ischemic and cardiopulmonary bypass times. Partially because of these delays, our cardiopulmonary bypass times had a wide range (30 to 77 minutes).

One of the difficulties in the removal of the hydatid cysts is the extreme fragility of the outer membrane and the risk of uncontrolled rupture with leakage of content into the pericardium or systemic circulation. If this happens or when a ruptured old cyst is discovered, it is mandatory to perform an enlarged pericardectomy. ¹⁹ Complete and rapid sterilization of the cyst content must be performed with the injection or instillation of such agents as 2% formalin, 0.5% silver nitrate solution, ²¹ 30% hypertonic saline solution, ¹⁹ 1% iode solution, and 5% cetimide solution. In our experience, we used hypertonic saline solution without adverse effects. If total excision of the cyst wall is not feasible because of the proximity of cardiac structures, the remaining cavity should be closed because complications have been observed in cases of simple drainage or marsupialization of the cavities. Closure of the cyst by obliteration and plication of the cavity was performed in six of our patients to provide a higher rigidity to the weakened cardiac wall (Fig. 6).

Operative mortality is very low, and the postoperative evolution is usually satisfactory and uncomplicated. ^{17, 18} Surgical excision is the best treatment, because no effective chemotherapy against larval cestode infections has been developed yet. However, some authors ¹⁷ advocate the use of routine medical therapy as a supplement to the operation. Since 1975, mebendazole ⁷ has been used with poor results. The usual dose is 30 to 40 mg/kg per day for 10 to 12 months. In recent years, new drugs such as flubendazole and albendazole have been used. ⁷

During the follow-up, echocardiographic and serologic controls are advisable to detect recurrences or other associated complications.

Di Bello and associates ²¹ reported four sudden deaths in patients who underwent operation years before, two of whom had ruptured cysts in the pericardium during the operation. The cause of death might be related to the rupture of cysts that were not discovered at operation or the proliferation of particles of cysts ruptured during surgical manipulation. Other causes could be tachyarrhythmias originating from the fibrous zone of excision. In our follow-up, sudden death occurred in a patient in whom a cyst involving the interventricular septum was excised 2 years before.

It is remarkable that five of our patients (55%) had multivisceral involvement (liver, lungs, kidneys, and heart), and this finding brought us to the conclusion that the reported prevalence of cardiac hydatidosis would be higher if cardiac structures were routinely explored in patients with multiple hydatic cyst disease.

Acknowledgments

We thank Dr. C. Obi for his assistance in the editing of this paper.

References

1. Dighiero J, Canabal EJ, Hazan J, Horlales JO. Echinococcus: disease of the heart. Circulation 1958;17:128-31.
   
2. Heyat I, Mokhtari H, Hajaliloo J, Shakibi JG. Surgical treatment of echinococcal cyst of the heart. J THORAC CARDIOVASC SURG 1971;61:755-64.[Medline]
   
3. Rausch RL. Taeniidae. In: Diseases transmitted from animals to man. Springfield, Ill: C. C. Thomas, 1975:678-707.
   
4. Stepien L. Cerebral cysticercosis in Poland: clinical symptoms and operative results in 132 cases. J Neurosurg 1962;19:505-13.[Medline]
   
5. Gibson DS. Cardiac hydatid cysts. Thorax 1964;19:151.[Medline]
   
6. Popo I, Savic S. Hydatid disease of the heart. Br J Surg 1962;49:598-600.[Medline]
   
7. Verger G. Helmintiasis histicas: Equinococosis. In: Enfermedades infecciosas. Barcelona: DOYMA SA, ed. 1988: 441-6.
   
8. Perez-Gomez F, Duran H, Tamames S, et al. Cardiac Echinococcosis: clinical picture and complications. Br Heart J 1973;35:1326-31.[Free Full Text]
   
9. Hazan E, Leblanc J, Robillard M, et al. Hydatid cyst of the right ventricle revealed by an acute complication: emergency exeresis with prosthetic replacement of the tricuspid valve. Chirurgie 1970;96:257-60.[Medline]
   
10. Vestri A, Nigri A, Massi L, et al. Electrocardiographic picture of myocardial infract during echinococcosis of the heart. Boll Soc Ital Cardiol 1972;17:752-4.[Medline]
    
11. Calamai G, Perna AM, Venturini A. Hydatid disease of the heart: report of five cases and review of the literature. Thorax 1974;29:451-8.[Abstract/Free Full Text]
    
12. Urquia M, Garrido J, de los Arcos E, et al. Hidatidosis del septo interventricular. Rev Clin Esp 1975;138:521-7.[Medline]
    
13. Munoz C, Portus M. Estudio comparativo de diversas tecnicas serologicas para el diagnostico de laboratorio de la hidatidosis. Rev Iber Parasitol 1982;(Suppl):345-58.
    
14. Varuela-Diaz VM, Coltorti EA, Preziosos U, Lopez-Lemes MH, Guisantes JA, Yarzabal LA. Evaluation of three immunodiagnostic test for human hydatid disease. Am J Trop Med Hyg 1975;24:312-9.
    
15. Farooki ZQ, Adelman S, Green EW. Echocardiographic differentiation of a cystic and solid tumor of the heart. Am J Cardiol 1977;39:107-11.[Medline]
    
16. Vanjak D, Moutaoufik M, Leroy O, et al. Hydatidose cardiaque: apport de l'imagerie par resonance magnetique. Arch Mal Coeur Vaiss 1990;83:1739-42.[Medline]
    
17. Ameli M, Mobarhan HA, Nouraii SS. Surgical treatment of hydatid cysts of the heart: report of six cases. J THORAC CARDIOVASC SURG 1989;98:892-901.[Abstract]
    
18. Shakibi JG, Safavian MH, Azar H, Siassi B. Surgical treatment of echinococcal cyst of the heart: report of two cases and review of the world literature. J THORAC CARDIOVASC SURG 1977;74:941-6.[Abstract]
    
19. Malmejac J, Hovel J, Metras D, et al. Hydatid cyst of the heart. Chirurgie 1970;96:261-7.[Medline]
    
20. Saidi F, Nazarian I. Surgical treatment of hydatid cysts by freezing of cyst wall and instillation of 0.5 percent silver nitrate solution. N Engl J Med 1971;284:1346-50.
    
21. Di Bello R, Sadi I, Esteves S. Abnormal precordial pulsation in cardiac echinococcosis. J THORAC CARDIOVASC SURG 1967;53:366-70.[Medline]
    

This article has been cited by other articles:

				A. Fazlinezhad, M. Moohebati, A. Azari, and L. Bigdeloo Acute pericardial tamponade due to ruptured multiloculated myocardial hydatid cyst Eur J Echocardiogr, May 1, 2009; 10(3): 459 - 461. [Full Text] [PDF]

				T. Mohsen, N. El Beharry, T. Maree, and E.S. Akl Cardiac echinococcosis of the interventricular septum in early childhood: report of two cases. J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): e14 - e16. [Full Text] [PDF]

				Y. L. Shevchenko, N. O. Travin, G. H. Musaev, and A. V. Morozov Heart echinococcosis: current problems and surgical treatment MMCTS, August 10, 2006; 2006(0810): 1115. [Abstract] [Full Text] [PDF]

				S. Tandon and A. Darbari Hydatid Cyst of the Right Atrium: A Rare Presentation Asian Cardiovasc Thorac Ann, June 1, 2006; 14(3): e43 - e44. [Abstract] [Full Text] [PDF]

				M. Ileri, I. Hisar, R. Atak, K. Senen, D. Aras, and N. Buyukasik A Pericardial Hydatid Cyst Masquerading as Acute Inferolateral Myocardial Infarction: A Case Report Angiology, September 1, 2005; 56(5): 637 - 640. [Abstract] [PDF]

				R. Curran and H. S. Paterson Surgical Treatment of Intramyocardial Foregut Cysts Ann. Thorac. Surg., August 1, 2005; 80(2): 737 - 739. [Abstract] [Full Text] [PDF]

				N. Bozbuga, V. Erentug, E. Akinci, and C. Yakut Is surgical therapy the only treatment of choice for cardiac echinococcossis with multiple organ involvement? Interactive CardioVascular and Thoracic Surgery, September 1, 2003; 2(3): 367 - 368. [Abstract] [Full Text] [PDF]

				C. L. Birincioglu, O. Tarcan, H. Bardakci, A. Saritas, and O. Tasdemir Off-pump technique for the treatment of ventricular myocardial echinococcosis Ann. Thorac. Surg., April 1, 2003; 75(4): 1232 - 1237. [Abstract] [Full Text] [PDF]

				A. Ozyazicioglu, H. Kocak, M. Ceviz, and A. Y. Balci Surgical Treatment of Echinococcal Cysts of the Heart: Report of 3 Cases Asian Cardiovasc Thorac Ann, March 1, 2002; 10(1): 66 - 68. [Abstract] [Full Text] [PDF]

				U. Ozergin, K. Durgut, N. Gormus, G. S. Sunam, and T. Yuksek Infected Myocardial Hydatid Cyst Imitating Pericardial Cyst Asian Cardiovasc Thorac Ann, December 1, 2001; 9(4): 320 - 321. [Abstract] [Full Text] [PDF]

				F. Kardelen, G. Akcurin, H. Ertug, and O. Beyazit Right Atrial Hydatid Cyst With Multiple Organ Involvement Asian Cardiovasc Thorac Ann, September 1, 2001; 9(3): 240 - 242. [Abstract] [Full Text] [PDF]

				J. G. Tejada, J. Saavedra, L. Molina, A. Forteza, and C. Gomez Hydatid disease of the interventricular septum causing pericardial effusion Ann. Thorac. Surg., June 1, 2001; 71(6): 2034 - 2035. [Abstract] [Full Text] [PDF]

				C. Ozbek, I. Ozsoyler, M. K. Arkci, T. Goktogan, E. Tonguc, C. Ozbek, I. Ozsoyler, M. K. Arkci, T. Goktogan, and E. Tonguc Cardiac Hydatid Cyst Asian Cardiovasc Thorac Ann, December 1, 2000; 8(4): 375 - 377. [Abstract] [Full Text] [PDF]

				K. Durgut, U. Ozergin, K. Ozdemir, N. Gormus, T. Yuksek, H. Solak, K. Durgut, U. Ozergin, K. Ozdemir, N. Gormus, et al. Hydatid Cyst on Right Ventricular Posterior Wall Asian Cardiovasc Thorac Ann, September 1, 2000; 8(3): 275 - 277. [Abstract] [Full Text] [PDF]

				C. Birincioglu, A. T. Ulus, K. Arda, and B. Yamak A clinical dilemma: cardiac and pericardiac echinococcosis Ann. Thorac. Surg., October 1, 1999; 68(4): 1290 - 1294. [Abstract] [Full Text] [PDF]

				S. Men, C. Yücesoy, T. R. Edgüer, and B. Hekimoglu Intraaortic Growth of Hydatid Cysts Causing Occlusion of the Aorta and of Both Iliac Arteries: Case Report Radiology, October 1, 1999; 213(1): 192 - 194. [Abstract] [Full Text]

				L. Elbeyli, R. Kervancioglu, M. Bayram, and A. Filiz Hydatid Cysts with Pulmonary and Cardiac Involvement Asian Cardiovasc Thorac Ann, September 1, 1999; 7(3): 236 - 237. [Abstract] [Full Text] [PDF]

				A. Uysalel, L. Yazicioglu, A. Aral, and H. Akalin A multivesicular cardiac hydatid cyst with hepatic involvement Eur. J. Cardiothorac. Surg., September 1, 1999; 14(3): 335 - 337. [Abstract] [Full Text] [PDF]

				L. C. Maroto, Y. Carrascal, M. J. Lopez, A. Forteza, A. Perez, and C. Zavanella Hydatid cyst of the interventricular septum in a 3.5-year-old child Ann. Thorac. Surg., December 1, 1998; 66(6): 2110 - 2111. [Abstract] [Full Text] [PDF]

				F. Oguzkaya, Y. Akcali, C. Kahraman, N. Emirogullari, M. Bilgin, and A. Sahin Unusually Located Hydatid Cysts: Intrathoracic but Extrapulmonary Ann. Thorac. Surg., August 1, 1997; 64(2): 334 - 337. [Abstract] [Full Text]

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Miralles, A. Articles by Cabrol, C. Search for Related Content PubMed PubMed Citation Articles by Miralles, A. Articles by Cabrol, C.