JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Yoshimasa Miyauchi
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Utoh, J.
Right arrow Articles by Miyauchi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Utoh, J.
Right arrow Articles by Miyauchi, Y.

J Thorac Cardiovasc Surg 1995;110:276
© 1995 Mosby, Inc.

LETTERS TO THE EDITOR

Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass?

Junichi Utoh, MD, PhDa, Tetsuro Yamamoto, MD, PhDb, Yoshimasa Miyauchi, MD, PhDa

First Department of Surgerya
Division of Molecular Pathologyb
Kumamoto University School of Medicine
Kumamoto, Japan

To the Editor

We read with interest the article titled "Neutrophil Leukotriene Generation Increases After Cardiopulmonary Bypass" by Gadaleta and associatesGo 1 in the October 1994 issue of the Journal. They showed an increased neutrophil leukotriene production during cardiopulmonary bypass (CPB) and speculated a relationship between neutrophil-derived leukotriene and inflammatory response after CPB. Using the same method (neutrophil separation from patients' blood, activation with calcium ionophore A23187, leukotriene quatification by reversed-phase high-pressure liquid chromatography), weGo 2 reported the postoperative changes in neutrophil leukotriene productivity after CPB in 1988. In our study, increase in neutrophil leukotriene B4 production and decrease in leukotriene C4 production were reported.

In 1989, weGo 3 developed a hypothesis that the change in neutrophil functions might be related to and specific for. CPB Perioperative neutrophils were studied in 20 patients having cardiac operations with CPB (n = 10) and other major operations (n = 10). The increased leukotriene B4-producing capacity and decreased leukotriene C4 production were similarly observed in the patients of both groups.Go 3 Therefore we concluded that the leukotriene productivity of neutrophils is altered during CPB, but this change is not specific for the type of operation with CPB. Unfortunately, Gadaleta and associatesGo 1 did not have a control study group to allow the specificity for CPB to be discussed.

References

  1. Gadaleta D, Fahey AL, Verma M, et al. Neutrophil leukotriene generation increases after cardiopulmonary bypass. J THORAC CARDIOVASC SURG 1994;108:642-7.[Abstract/Free Full Text]
  2. Utoh J, Yamamoto T, Utsunomiya T, Kambara T, Goto H, Miyauchi Y. Effect of surgery on neutrophil functions, superoxide and leukotriene production. Br J Surg 1988;75:682-5.[Medline]
  3. Utoh J, Yamamoto T, Kambara T, Goto H, Miyauchi Y. Perioperative alteration of neutrophil functions after open heart and other major surgeries. J Cardiovasc Surg 1989;30:692-5.[Medline]



This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
N. de Prost, C. El-Karak, M. Avila, F. Ichinose, and M. F. Vidal Melo
Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease
J. Thorac. Cardiovasc. Surg., June 1, 2011; 141(6): 1496 - 1502.e3.
[Abstract] [Full Text] [PDF]

Home page
 PerfusionHome page
S W Sutton, A N Patel, V A Chase, L A Schmidt, E K Hunley, L W Yancey, R F Hebeler, E H Cheung, A C Henry III, T P Meyers, et al.
Clinical benefits of continuous leukocyte filtration during cardiopulmonary bypass in patients undergoing valvular repair or replacement
Perfusion, January 1, 2005; 20(1): 21 - 29.
[Abstract] [PDF]

Home page
 SEMIN CARDIOTHORAC VASC ANESTHHome page
H. A. Hennein
Inflammation After Cardiopulmonary Bypass: Therapy for the Postpump Syndrome
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 236 - 255.
[Abstract] [PDF]

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Yoshimasa Miyauchi
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Utoh, J.
Right arrow Articles by Miyauchi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Utoh, J.
Right arrow Articles by Miyauchi, Y.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS