HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Doff B. McElhinney Norman H. Silverman Stefano M. Marianeschi Frank L. Hanley Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Reddy, V. M. Articles by Hanley, F. L. Search for Related Content PubMed PubMed Citation Articles by Reddy, V. M. Articles by Hanley, F. L.

J Thorac Cardiovasc Surg 1998;116:21-25
© 1998 Mosby, Inc.

Surgery For Congenital Heart Disease

Partial biventricular repair for complex congenital heart defects: an intermediate option for complicated anatomy or functionally borderline right complex heart

Read at the Twenty-third Annual Meeting of The Western Thoracic Surgical Association, Napa, Calif., June 25-28, 1997.

Received for publication July 8, 1997. Revisions requested Oct. 9, 1997; revisions received Feb. 11, 1998. Accepted for publication Feb. 19, 1998. Address for reprints: V. Mohan Reddy, MD, Division of Cardiothoracic Surgery, 505 Parnassus Ave., M593, San Francisco, CA 94143-0118.

	Abstract

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 
Background: Partial biventricular repair consists of bidirectional cavopulmonary anastomosis in the presence of separated systemic and pulmonary circulations, with antegrade flow of inferior caval return through an intact or reconstructed pulmonary outflow tract. This versatile procedure may be used as a definitive repair for patients with a functional right heart complex incapable of supporting an entire cardiac output or in patients with complicated anatomy.
Methods: From July 1992 to April 1997, 23 patients (median age 5.2 years) underwent partial biventricular repair. In 15 of these cases the entire repair, including bidirectional cavopulmonary anastomosis, intracardiac repair, and right ventricular outflow reconstruction, was performed as a planned procedure at our institution. The other eight patients had previously been placed on a Fontan track and had undergone bidirectional cavopulmonary anastomosis; their circulations were converted to a partial biventricular circulation.
Results: There were no early deaths. Complete atrioventricular block developed in two patients with straddling tricuspid valve. At a median follow-up of 17 months, there were no late deaths and three patients had undergone reintervention. Partitioning of the pulmonary arteries to create a classic Glenn anastomosis with antegrade flow to the left lung was performed in one case; another patient underwent an atrial septectomy, and the third patient required revision of tricuspid valve repair. All patients are in New York Heart Association functional class I.
Conclusions: Partial biventricular repair is a versatile strategy that can be used to manage a variety of forms of complex congenital heart disease. Cases for which the repair is useful include those in which complete biventricular repair is unlikely to be achieved because of limited size or function of the right side of the heart and those in which a patient with a ventricle capable of supporting inferior vena caval return was previously placed on a Fontan track.

	Introduction

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 
As experience accumulates with single-ventricle palliation for complex congenital heart disease, it has become clear that there is a spectrum of palliative options that may be appropriate in different cases. The choice between univentricular and biventricular repair remains unclear for a range of borderline lesions. ^1-3 Moreover, there is controversy surrounding such issues as whether to supplement a bidirectional Glenn anastomosis with additional pulmonary blood flow ^4-7 and whether to fenestrate a Fontan procedure. ^8,9 Other innovative approaches have also been suggested. ^10-14 An intermediate option that may be suitable in particular cases is partial biventricular repair, in which intracardiac repair is supplemented with a bidirectional cavopulmonary anastomosis. ^15-20 This approach allows the maintenance of equal and separate pulmonary and systemic circulations while at the same time incorporating the pulmonary ventricle into the circulation with a reduced volume load. Since July 1992, partial biventricular repair has been performed in 23 patients who either had a functionally borderline right side of the heart or had previously been placed on a Fontan track primarily because of complicated anatomy.

	Patients and methods

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 
Patients
Between July 1992 and April 1997, 23 patients underwent partial biventricular repair. The left and right sides of the heart were completely separated by closing all septal defects, maintaining or reconstructing the pulmonary outflow tract, and routing superior vena caval flow directly to the lungs through a bidirectional cavopulmonary anastomosis. The median age was 5.2 years (7 months to 32 years). This is a significantly older population than our overall cohort of patients undergoing bidirectional cavopulmonary anastomosis during the same period (median 7 months; p < 0.001). Patients were categorized in two groups. Group I patients (n = 15) underwent planned partial biventricular repair with bidirectional cavopulmonary shunt and intracardiac repair at our institution. Group II patients (n = 8) had previously undergone bidirectional cavopulmonary anastomosis in preparation for an eventual Fontan operation, in most cases because of a combination of complicated anatomy and mild to moderate ventricular hypoplasia, and underwent conversion to partial biventricular repair at our institution. Ages were similar between the two groups, but group I patients had undergone significantly fewer previous procedures than had group II patients (not including previous bidirectional Glenn anastomosis, mean ± standard deviation 0.9 ± 1.0 vs 2.3 ± 1.3, p = 0.01). Diagnoses of group I patients were Ebstein's anomaly (n = 6), pulmonary atresia with intact ventricular septum (n = 4), pulmonary atresia or stenosis with hypoplasia of the right side of the heart and ventricular septal defect (n = 4), and other hypoplastic right ventricle (n = 1). Other associated defects in these patients were straddling tricuspid valve (n = 1), partially anomalous pulmonary venous drainage to a left superior vena cava (n = 1), and coronary sinus septal defect (n = 1). Nine patients had significant tricuspid valvular regurgitation: two mild cases, six moderate cases, and one severe case. Among the nine patients with hypoplastic right ventricle and tricuspid valve, tricuspid Z values ranged from –1 to –5 (median –2.5). Significant ventricle–coronary arterial connections were not present in any of the patients. There was a range of diagnoses among group II patients (Table I), all of whom had undergone bidirectional Glenn anastomosis between 20 months and 4 years before conversion to partial biventricular repair.

Patients in group II had previously undergone bidirectional cavopulmonary anastomosis. Procedures performed at the time of conversion to partial biventricular repair are listed in Table I. Cardiopulmonary bypass was used in all cases and ranged in duration from 85 to 209 minutes (median 136 minutes).

	Results

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 
There were no early deaths. The only early reoperation was a partitioning of the bidirectional Glenn anastomosis to create a classic Glenn anastomosis to the right lung and antegrade flow from the right ventricle to the left lung in a group I patient with hypoplasia of the right side of the heart, pulmonary atresia, and ventricular septal defect who developed superior vena cava syndrome. Among the nine patients with preoperative tricuspid regurgitation, the regurgitation was reduced to none (n = 3), trace (n = 5), or mild (n = 1). No patient required prolonged chest tube drainage for pleural or pericardial effusions. On the day of extubation, pressures in the superior vena cava ranged from 8 to 18 mm Hg (median 12 mm Hg), and pressures in the right atrium ranged from 2 to 11 mm Hg (median 5 mm Hg). Patients were discharged after a median hospital stay of 8 days (range 3 to 25 days).

Cross-sectional follow-up was obtained at a median of 19 months (range 2 to 58 months) and was complete in all cases. There were no late deaths, and no patients required take-down of the Glenn anastomosis. Two group I patients underwent late reoperation. A patient with pulmonary atresia and intact ventricular septum had a small atrial septectomy performed 7 months after partial biventricular repair to decompress the right atrium and ventricle. This patient had a preoperative tricuspid valve Z value of –4 (Fig. 1). A patient with Ebstein's anomaly and severe tricuspid regurgitation required revision of the tricuspid valve repair 6 months later for recurrent moderate regurgitation. At follow-up echocardiography, tricuspid valve Z values in patients with hypoplastic right ventricle and tricuspid valve did not differ significantly from before the operation, and tricuspid regurgitation had not returned or progressed in any of the other patients with preoperative regurgitation. No patient had undergone follow-up cardiac catheterization. Arterial oxygen saturation ranged from 93% to 99%, with a median of 96%.

View larger version (118K): [in this window] [in a new window]   Fig. 1. Preoperative apical four-chamber echocardiogram from a group I patient with pulmonary atresia with intact ventricular septum and a tricuspid valve Z value of –4 who had a small atrial septectomy performed 7 months after partial biventricular repair as a result of failure of the right side of the heart to grow. LA, Left atrium; RA, right atrium; LV, left ventricle; RV, right ventricle.

	Discussion

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

The principle of partial biventricular repair is to create a modified in-series circulation, with no left-right or right-left shunting, the systemic ventricle pumping a single cardiac output, and the pulmonary circulation receiving full cardiac output through contributions of both the pulmonary ventricle and the superior cavopulmonary connection. This approach allows the maintenance of equal pulmonary and systemic flows, and the bidirectional cavopulmonary shunt simultaneously reduces the volume load on the right ventricle. This allows a hypoplastic right heart complex to adequately handle the reduced preload. It also enables aggressive tricuspid valve repair in patients with Ebstein's anomaly without the risk of iatrogenic tricuspid stenosis.

Although bidirectional cavopulmonary anastomosis is widely used for patients with a variety of forms of complex congenital heart disease, there are several concerns with this procedure as a form of long-term palliation. These include progressive desaturation, as the proportion of flow to the upper body (and thus through the superior vena cava) decreases in relation to patient size, and pulmonary vascular changes, such as pulmonary arteriovenous fistulas, ²⁷ aortopulmonary collateral arteries, ²⁸ systemic venous collaterals, ²⁹ and potentially poor pulmonary artery growth. ³⁰ However, these potential complications might be reduced or eliminated by allowing antegrade flow through the main pulmonary artery, which provides pulsatility, increased absolute volume and flow rate, and hepatic venous blood to both lungs.

Indications for partial biventricular repair
Possible indications for partial biventricular repair can be classified in a number of different ways. Van Arsdell and colleagues ¹⁸ divided patients into the following four groups: small physiologic right ventricle (group A), chronic right ventricular dysfunction (group B), facilitation of biventricular repair without hypoplasia or functional impairment of the pulmonary ventricle (group C), and acute right ventricular dysfunction (group D). ¹⁸ Patients in our series fell into two basic groups: those with borderline function of the right side of the heart (group I) and those in whom previous bidirectional Glenn anastomosis had been performed, usually on the basis of complicated anatomy, but for whom complete or partial biventricular repair was possible with additional complex procedures (group II). Other published series have generally included patients with a single lesion or surgical indication. ^15-17,19,20

In our cohort of patients with borderline function of the right side of the heart, partial biventricular repair was indicated on the basis of a small right ventricle, functional compromise, or both. This category thus includes both groups A and B of the series of Van Arsdell and colleagues. ¹⁸ The former category may include patients with pulmonary atresia and intact ventricular septum or other lesions with a hypoplastic right ventricle. The latter group may include such lesions as Ebstein's anomaly and isolated tricuspid stenosis without right ventricular hypoplasia. It is difficult to posit definitive size or functional guidelines for partial biventricular repair on the basis of our relatively limited experience and the available literature, especially in light of the diversity of lesions repaired. In the 1993 Congenital Heart Surgeons' Society multiinstitutional study ² on neonatal management of pulmonary atresia with intact ventricular septum, the only risk factor militating against biventricular repair was small tricuspid valve Z value (continuous variable). The predicted prevalence of biventricular repair at 5 years was less than 30% for a Z value of –3 and less than 50% for a Z value of –2. According to this study, almost 50% of patients with a tricuspid valve Z value of –2 would be predicted to have a mixed (incompletely separated) circulation at the age of 5 years. Patients with a tricuspid valve diameter in this range may be the most suitable candidates for partial biventricular repair, as has been the case in our experience. We were able to perform partial biventricular repair in patients with tricuspid valve Z values as low as –5, but the need to create an atrial septectomy (in effect failure of the partial biventricular repair) in a patient with a tricuspid Z value of –4 suggests that such severe hypoplasia of the right side of the heart may not be consistently amenable to this intermediate form of definitive palliation.

For moderate and severe forms of Ebstein's anomaly, partial biventricular repair adds another dimension to the range of surgical approaches. Decreasing right ventricular preload by performing a bidirectional Glenn anastomosis may lead to improved right ventricular and tricuspid valvular function, with or without tricuspid valvuloplasty. In most of our cases of Ebstein's anomaly, some form of tricuspid valvuloplasty or annuloplasty was performed, but two patients had improvement in tricuspid regurgitation from mild or moderate to trivial without any valve intervention, presumably as a result of improvement in coaptation caused by decreased right ventricular volume and tricuspid annular dilatation. For all patients with borderline function of the right side of the heart, the decision to proceed with partial biventricular repair need not be made before the operation. For patients who may be able to tolerate complete biventricular repair, this is attempted and the patient is then separated from bypass. If right atrial pressure is too high (more than 12 mm Hg or twice left atrial pressure) or tricuspid valvular function is inadequate according to transesophageal echocardiography, a bidirectional Glenn anastomosis is added. The bidirectional Glenn anastomosis can be performed without cardiopulmonary bypass, adding little risk to the operation.

Group II patients, who had previously undergone bidirectional Glenn anastomosis in preparation for an ultimate Fontan operation, had a range of anomalies. Among them were two patients with corrected transposition of the great arteries and pulmonary atresia, one with double-outlet left ventricle, and one with transposition of the great arteries and a straddling tricuspid valve, all of which were revised to partial biventricular repair with the use of fairly new surgical approaches. In the patients with corrected transposition of the great arteries, we performed a double-switch procedure, with a Rastelli procedure and a modified Mustard procedure, in which the atrial baffle extended around the orifice of the inferior vena cava but not of the superior cava. This approach, also referred to by the Toronto group for two of their group C patients, ¹⁸ simplifies the Mustard component of a double-switch procedure, reduces bypass time, decreases atrial suture line, and may lead to a lower incidence of venoatrial obstruction than is the case with a standard full Mustard baffle. In our patient with double-outlet left ventricle, we transposed the pulmonary root into the right ventricle. Although this would probably have been adequate for complete biventricular repair, the bidirectional Glenn anastomosis was left in place. In the patient with transposition of the great arteries, hypoplastic right ventricle, and a straddling tricuspid valve, an arterial switch was performed and the valvular anomaly was corrected by transecting the straddling chordae and reattaching them in the right ventricle, as we previously described. ²⁰ The bidirectional Glenn anastomosis was also left in place in this patient because of the small size of the right ventricle (Fig. 2).

View larger version (102K): [in this window] [in a new window]   Fig. 2. Preoperative apical four-chamber echocardiogram from a group II patient with transposition of the great arteries, right ventricular hypoplasia, and straddling of the tricuspid valve (arrow). This patient underwent arterial switch and reimplantation of the straddling chordae on the right ventricular side of the septum 22 months after bidirectional Glenn anastomosis. Abbreviations are as in Fig. 1.

	Appendix: Discussion

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 
Dr. Hillel Laks (Los Angeles, Calif.). This is a fascinating and interesting area in cardiac surgery, the distinction between biventricular, univentricular, and what is described as "partial biventricular" or "one and a half ventricle" repair. Attempted biventricular repair for patients with hypoplastic right ventricle is associated with a high mortality rate, and another group showed that unless the right ventricle was within the 90% confidence limits of normal size, the mortality rate was extraordinarily high. In 1989 we described what we called the "partial biventricular" repair, which included leaving an adjustable atrial septal defect, snare controlled, that would allow as much as one third of the systemic venous return to cross from the right atrium to the left atrium and allow a smaller right ventricle to carry as much as two thirds of the venous return. In that same publication, we included a description of the bidirectional Glenn shunt for those ventricles that were between one third and one half normal size, which would correlate with Z values of tricuspid valve size down to –5 or –6. This allowed one to do these partial biventricular repairs with acceptable results.

In your series, which included six cases of Ebstein's anomaly, in which right ventricular size is generally normal, could some of these patients have undergone a biventricular repair with the adjustable atrial septal defect without the need for the Glenn shunt?

Dr. Reddy. I think that it is a matter of the surgeon's preference whether an adjustable atrial septal defect or a cavopulmonary shunt is used. I am pretty certain that these patients could have had adjustable atrial septal defect. The reason that we generally have gone on to do bidirectional cavopulmonary anastomoses in these patients is that with an adjustable atrial septal defect there is still some mixing, whereas there is none with the cavopulmonary shunt. Also, we were able to aggressively repair the tricuspid valve and try to eliminate all the tricuspid regurgitation by doing an aggressive annuloplasty, to the point at which a stenosis would have been created if one cardiac output is pumped through the tricuspid valve.

Dr. Laks. The advantage of the adjustable atrial septal defect is that as the right ventricle grows, one can go back and close it without, of course, needing bypass. My other question is related to the reconstruction of the right ventricle. If one does a bidirectional Glenn shunt, the pulmonary artery pressure will usually rise to a mean of 12 to 15 or 16 mm Hg, and in the absence of a confident pulmonary valve the right ventricular end-diastolic pressure may rise to similar levels. If the atrial septal defect is closed, the right atrial pressure will then rise to that same level again, which would negate some of the advantages of partial biventricular repair. We have therefore incorporated as part of this operation the insertion of a pulmonary valve to lower the right ventricular end-diastolic pressure. Have you have had a similar experience? What have your postoperative right atrial pressures been, and have you begun to insert valves as part of the initial repair?

Dr. Reddy. We have not inserted any valves as a part of the repair as yet, but I completely agree with you that pulmonary insufficiency is a major concern in the cases in which you have to do a right ventricular outflow tract procedure. We have generally tried to do a careful valvotomy if necessary and have tried to place a small transannular patch and limit the pulmonary insufficiency by not resecting too much of the right ventricle. However, some of these patients may need pulmonary valve insertion during follow-up.

Dr. Laks. Although there are advantages to the bidirectional Glenn shunt, there is also something of a down side. If there indeed is differentiation between the superior vena caval and inferior vena caval pressures, venous collaterals may develop to divert blood from the higher pressure superior vena cava down to the lower pressure inferior vena cava, as we have seen in long-term follow-up of some of these patients. This has yielded a semicircular circulation, in which blood is being diverted down and recirculating. We also had one case, and when we reviewed the literature we found another, in which the highly pulsatile flow from the entire right ventricular cardiac output going to the pulmonary arteries resulted in an aneurysm formation in the superior vena cava. In our case we had to go back and reduce this and put in a pulmonary valve. Have you seen this complication? In view of that concern and the fact that some of these patients have severely pulsatile neck veins when there is a large pulse pressure, I think that one should emphasize trying to go to a biventricular repair whenever possible and to avoid the Glenn anastomosis, which can be done with the adjustable atrial septal defect.

Dr. Reddy. We have not seen that complication in our experience, but I certainly agree that it would be important to follow up these patients to observe for development of any of these complications. I think that with long-term follow-up, we will be able to clearly define the groups that would benefit from a cavopulmonary shunt and those that would benefit from adjustable atrial septal defect.

	References

Top Abstract Introduction Patients and methods Results Discussion Appendix: Discussion References

 

1. Rhodes LA, Colan SD, Perry SB, Jonas RA, Sanders SP. Predictors of survival in neonates with critical aortic stenosis. Circulation 1991;84:2325-35.[Abstract/Free Full Text]
   
2. Hanley FL, Sade RM, Blackstone EH, Kirklin JW, Freedom RM, Nanda NC. Outcomes in neonatal pulmonary atresia with intact ventricular septum: a multiinstitutional study. J Thorac Cardiovasc Surg 1993;105:406-23.[Abstract]
   
3. Delius RE, Rademecker MA, de Leval MR, Elliott MJ, Stark J. Is a high-risk biventricular repair always preferable to conversion to a single ventricle repair? J Thorac Cardiovasc Surg 1996;112:1561-9.[Abstract/Free Full Text]
   
4. Frommelt MA, Frommelt PC, Berger S, Pelech AN, Lewis DA, Tweddell JS, et al. Does an additional source of pulmonary blood flow alter outcome after a bidirectional cavopulmonary shunt? Circulation 1995;92(9 suppl):II240-4.
   
5. Webber SA, Horvath P, LeBlanc JG, Slavik Z, Lamb RK, Monro JL, et al. Influence of competitive pulmonary blood flow on the bidirectional superior cavopulmonary shunt: a multi-institutional study. Circulation 1995;92(9 suppl):II279-86.
   
6. Mainwaring RD, Lamberti JJ, Uzark K, Spicer RL. Bidirectional Glenn: is accessory pulmonary blood flow good or bad? Circulation 1995;92(9 suppl):II294-7.
   
7. Uemura H, Yagihara T, Kawashima Y, Okada K, Kamiya T, Anderson RH. Use of the bidirectional Glenn procedure in the presence of forward flow from the ventricles to the pulmonary arteries. Circulation 1995;92(9 suppl):II228-32.
   
8. Bridges ND, Mayer JE Jr, Lock JE, Jonas RA, Hanley FL, Keane JF, et al. Effect of baffle fenestration on outcome of the modified Fontan operation. Circulation 1992;86:1762-9.[Abstract/Free Full Text]
   
9. Mavroudis C, Zales VR, Backer CL, Muster AJ, Latson LA. Fenestrated Fontan with delayed catheter closure: effects of volume loading and baffle fenestration on cardiac index and oxygen delivery. Circulation 1992;86(5 suppl):II85-92.
   
10. Day R, Laks H, Milgalter E, Billingsley A, Rosengart R, George B. Partial biventricular repair for double-outlet right ventricle with left ventricular hypoplasia. Ann Thorac Surg 1990;49:1003-5.[Abstract]
    
11. Laks H, Pearl JM, Drinkwater DC, Jarmakani J, Isabel-Jones J, George BL, et al. Partial biventricular repair of pulmonary atresia with intact ventricular septum: Use of an adjustable atrial septal defect. Circulation 1992;86(5 suppl):II159-66.
    
12. Gentles TL, Keane JF, Jonas RA, Marx GE, Mayer JE. Surgical alternatives to the Fontan procedure incorporating a hypoplastic right ventricle. Circulation 1994;90(5 Pt 2):II1-6.
    
13. Leung MP, Lee J, Lo RNS, Mok CK. Modified Fontan procedure for severe Ebstein's malformation with predominant tricuspid stenosis. Ann Thorac Surg 1992;54:523-7.[Abstract]
    
14. Laks H, Ardehali A, Grant PW, Permut L, Aharon A, Kuhn M, et al. Modification of the Fontan procedure: superior vena cava to left pulmonary artery connection and inferior vena cava to right pulmonary artery connection with adjustable atrial septal defect. Circulation 1995;91:2943-7.[Abstract/Free Full Text]
    
15. Billingsley AM, Laks H, Boyce SW, George B, Santulli T, Williams RG. Definitive repair in patients with pulmonary atresia and intact ventricular septum. J Thorac Cardiovasc Surg 1989;97:746-54.[Abstract]
    
16. Muster AJ, Zales VR, Ilbawi MN, Backer CL, Duffy CE, Mavroudis C. Biventricular repair of hypoplastic right ventricle assisted by pulsatile bidirectional cavopulmonary anastomosis. J  Thorac Cardiovasc Surg 1993;105:112-9.[Abstract]
    
17. Miyaji K, Shimada M, Sekiguchi A, Ishizawa A, Isoda T, Tsunemoto M. Pulmonary atresia with intact ventricular septum: long-term results of one and a half ventricle repair. Ann Thorac Surg 1995;60:1762-4.[Abstract/Free Full Text]
    
18. Van Arsdell GS, Williams WG, Maser CM, Streitenberger KS, Rebeyka IM, Coles JG, et al. Superior vena cava to pulmonary artery anastomosis: an adjunct to biventricular repair. J Thorac Cardiovasc Surg 1996;112:1143-9.[Abstract/Free Full Text]
    
19. Clapp SK, Tantengco V, Walters HL, Lobdell KW, Hakimi M. Bidirectional cavopulmonary anastomosis with intracardiac repair. Ann Thorac Surg 1997;63:746-50.[Abstract/Free Full Text]
    
20. Reddy VM, Liddicoat JR, McElhinney DB, Brook MM, van Son JAM, Hanley FL. Biventricular repair of lesions with straddling tricuspid valves using techniques of chordal translocation and realignment. Cardiol Young 1997;7:147-52.
    
21. Lamberti JJ, Spicer RL, Waldman JD, Grehl TM, Thomson D, George L, et al. The bidirectional cavopulmonary shunt. J Thorac Cardiovasc Surg 1990;100:22-30.[Abstract]
    
22. Cetta F, Feldt RH, O'Leary PW, Mair DD, Warnes CA, Driscoll DJ, et al. Improved early morbidity and mortality after Fontan operation: the Mayo Clinic experience, 1987 to 1992. J Am Coll Cardiol 1996;28:480-6.[Abstract]
    
23. de Leval MR, Kilner P, Gewillig M, Bull C. Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. J Thorac Cardiovasc Surg 1988;96:682-95.[Abstract]
    
24. Bridges ND, Jonas RA, Mayer JE, Flanagan MF, Keane JF, Castaneda AR. Bidirectional cavopulmonary anastomosis as interim palliation for high-risk Fontan candidates: early results. Circulation 1990;82(5 suppl):IV170-6.
    
25. Forbess JM, Cook N, Serraf A, Burke RP, Mayer JE, Jonas RA. An institutional experience with second- and third-stage palliative procedures for hypoplastic left heart syndrome: the impact of bidirectional cavopulmonary shunt. J Am Coll Cardiol 1997;29:665-70.[Abstract]
    
26. Pridjian AK, Mendelsohn AM, Lupinetti FM, Beekman RH 3d, Dick M 2d, Serwer G, et al. Usefulness of the bidirectional Glenn procedure as staged reconstruction for the functional single ventricle. Am J Cardiol 1993;71:959-962.[Medline]
    
27. Bernstein HS, Brook MM, Silverman NH, Bristow J. Development of pulmonary arteriovenous fistulae in children after cavopulmonary shunt. Circulation 1995;92(9 suppl):II309-14.
    
28. Triedman JK, Bridges ND, Mayer JE, Lock JE. Prevalence and risk factors for aortopulmonary collateral vessels after Fontan and bidirectional Glenn procedures. J Am Coll Cardiol 1993;22:207-15.[Abstract]
    
29. McElhinney DB, Reddy VM, Hanley FL, Moore P. Systemic venous collaterals causing desaturation after bidirectional cavopulmonary anastomosis: evaluation and management. J Am Coll Cardiol 1997;30:817-24.[Abstract]
    
30. Mendelsohn AM, Bove EL, Lupinetti FM, Crowley DC, Lloyd TR, Beekman RH. Central pulmonary artery growth patterns after the bidirectional Glenn procedure. J Thorac Cardiovasc Surg 1994;107:1284-90.[Abstract/Free Full Text]
    

This article has been cited by other articles:

				S. Kim, O. Al-Radi, M. K. Friedberg, C. A. Caldarone, J. G. Coles, E. Oechslin, W. G. Williams, and G. S. Van Arsdell Superior vena cava to pulmonary artery anastomosis as an adjunct to biventricular repair: 38-year follow-up. Ann. Thorac. Surg., May 1, 2009; 87(5): 1475 - 1482. [Abstract] [Full Text] [PDF]

				H. Laks, D. Marelli, M. Plunkett, and J. Myers Adult Congenital Heart Disease Card. Surg. Adult, January 1, 2008; 3(2008): 1431 - 1464. [Full Text]

				S. M. Chauvaud, A. C. Hernigou, E. R. Mousseaux, D. Sidi, and J.-L. Hebert Ventricular Volumes in Ebstein's Anomaly: X-Ray Multislice Computed Tomography Before and After Repair Ann. Thorac. Surg., April 1, 2006; 81(4): 1443 - 1449. [Abstract] [Full Text] [PDF]

				N. Yoshimura, M. Yamaguchi, H. Ohashi, Y. Oshima, S. Oka, M. Yoshida, H. Murakami, and T. Tei Pulmonary atresia with intact ventricular septum: Strategy based on right ventricular morphology J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1417 - 1426. [Abstract] [Full Text] [PDF]

				S. Numata, H. Uemura, T. Yagihara, K. Kagisaki, M. Takahashi, and H. Ohuchi Long-term functional results of the one and one half ventricular repair for the spectrum of patients with pulmonary atresia/stenosis with intact ventricular septum Eur. J. Cardiothorac. Surg., October 1, 2003; 24(4): 516 - 520. [Abstract] [Full Text] [PDF]

				G. Stellin, V.L. Vida, O. Milanesi, M. Rubino, M.A. Padalino, S. Secchieri, G. Pittarello, and D. Casarotto Surgical treatment of complex cardiac anomalies: the 'one and one half ventricle repair' Eur. J. Cardiothorac. Surg., December 1, 2002; 22(6): 1043 - 1049. [Abstract] [Full Text] [PDF]

				G. Stellin, V.L. Vida, O. Milanesi, M. Rubino, M.A. Padalino, S. Secchieri, G. Pittarello, and D. Casarotto Surgical treatment of complex cardiac anomalies: the 'one and one half ventricle repair' Eur. J. Cardiothorac. Surg., September 1, 2002; 22(3): 431 - 437. [Abstract] [Full Text] [PDF]

				U. K. Chowdhury, B. Airan, R. Sharma, A. Bhan, S. S. Kothari, A. Saxena, and P. Venugopal One and a half ventricle repair with pulsatile bidirectional Glenn: results and guidelines for patient selection Ann. Thorac. Surg., June 1, 2001; 71(6): 1995 - 2002. [Abstract] [Full Text] [PDF]

				H Leonard, G Derrick, J O'Sullivan, and C Wren Natural and unnatural history of pulmonary atresia Heart, November 1, 2000; 84(5): 499 - 503. [Abstract] [Full Text]

				M. Alwi, K. Geetha, A. A. Bilkis, M. K. Lim, S. Hasri, A. L. Haifa, A. Sallehudin, and R. Zambahari Pulmonary atresia with intact ventricular septum percutaneous radiofrequency-assisted valvotomy and balloon dilation versus surgical valvotomy and blalock taussig shunt J. Am. Coll. Cardiol., February 1, 2000; 35(2): 468 - 476. [Abstract] [Full Text] [PDF]

				C. Mavroudis, C. L. Backer, L. M. Kohr, B. J. Deal, J. Stinios, A. J. Muster, and D. F. Wax Bidirectional Glenn shunt in association with congenital heart repairs: the 1 1/2 ventricular repair Ann. Thorac. Surg., September 1, 1999; 68(3): 976 - 981. [Abstract] [Full Text] [PDF]

				F. L. Hanley EDITORIAL: THE ONE AND A HALF VENTRICLE REPAIR--WE CAN DO IT, BUT SHOULD WE DO IT? J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 659 - 661. [Full Text] [PDF]

				C. Kreutzer, R. d. C. Mayorquim, G. O. A. Kreutzer, W. Conejeros, M. I. Roman, H. Vazquez, A. J. Schlichter, and E. A. Kreutzer EXPERIENCE WITH ONE AND A HALF VENTRICLE REPAIR J. Thorac. Cardiovasc. Surg., April 1, 1999; 117(4): 662 - 668. [Abstract] [Full Text] [PDF]

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Doff B. McElhinney Norman H. Silverman Stefano M. Marianeschi Frank L. Hanley Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Reddy, V. M. Articles by Hanley, F. L. Search for Related Content PubMed PubMed Citation Articles by Reddy, V. M. Articles by Hanley, F. L.