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J Thorac Cardiovasc Surg 2000;119:358-367
© 2000 Mosby, Inc.
SURGERY FOR CONGENITAL HEART DISEASE |
From the Departments of Cardiac Surgerya and Cardiology,b Children’s Hospital, Boston, Mass.
Address for reprints: Richard A. Jonas, MD, Department of Cardiac Surgery, Children’s Hospital, Bader 2, 300 Longwood Ave, Boston, MA 02115 (E-mail: richardjonas{at}compuserve.com).
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Abstract |
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 Top Abstract IntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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Introduction |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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1 Physiologic features are those of a single right ventricle with unobstructed pulmonary blood flow into well-developed pulmonary arteries and a ductus-dependent systemic circulation. Survival is unlikely without surgical therapy. 2 The pioneering work of Norwood and associates 3,4 has led gradually to widespread surgical treatment of patients with this malformation. The principles are establishment of a permanent communication between the systemic ventricle and the aorta, relief of systemic outflow obstruction by augmentation of the ascending aorta and arch, restriction of pulmonary blood flow by a modified Blalock-Taussig shunt, and creation of a large interatrial communication. Various other cardiac malformations share the features of parallel systemic and pulmonary circulations with hypoplasia or obstruction of the systemic outflow, unobstructed pulmonary blood flow, and a ductus-dependent systemic circulation. In the presence of two well-developed ventricles and atrioventricular valves, surgical treatment aims at a two-ventricle repair. In the absence of one of the two, the Norwood concept of palliation is applicable.
At Children’s Hospital, Boston, a variety of malformations other than classic HLHS were treated with the Norwood procedure by creating a pulmonary artery–aortic anastomosis, relieving arch obstruction, and providing pulmonary blood flow by a shunt. The aim of this study was to assess the results of this therapy for this heterogeneous subset of patients. To gain further insights into the pathophysiology, we compared these results with our experience with the Norwood procedure in patients with typical HLHS.
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Patients and methods |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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5 were used to differentiate between patients with HLHS and those with critical aortic stenosis. Table I describes the anatomic subgroups with respect to aortic and mitral valve anatomy. The Norwood procedure was also applied in a second group of 63 patients with other malformations associated with systemic outflow obstruction within the heart and aortic arch obstruction (Table II). Subgroups were hypoplastic left-sided structures with ventricular septal defect (VSD) (n = 18); unbalanced complete atrioventricular canal (n = 9); complex double-outlet right ventricle (n = 14); double-inlet left ventricle and single left ventricle (n = 11); tricuspid atresia with transposition of the great arteries (n = 6); and miscellaneous (n = 5), including heterotaxia (polysplenia [n = 2] and asplenia [n = 1]). A well-developed morphologically left ventricle was present in 27 of these patients; nine of those had two good-sized ventricles (1 with complete atrioventricular canal, 4 with complex double-outlet right ventricle, 2 with hypoplastic left-sided structures with VSD, and 2 with miscellaneous malformations). They were not suitable for a two-ventricle repair because of severe stenosis or straddling of one atrioventricular valve.
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Eleven patients (5.7%) had a virtually intact atrial septum or a highly restrictive atrial septal defect (ASD), which was enlarged in all but one during cardiac catheterization before surgical palliation. Additional anatomic findings are listed in Table III. One patient had had an attempt at a two-ventricle repair with VSD closure and died after a subsequent conversion to a Norwood procedure. None of the other patients had a previous surgical procedure.
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Surgical technique consisted of the creation of a free communication between the systemic ventricle and the aorta with a pulmonary-aortic anastomosis and arch augmentation with a pulmonary (41%) or aortic homograft (52%) or other techniques (7%). Pulmonary blood flow was provided by a modified Blalock-Taussig shunt of 3 mm (4%), 3.5 mm (85%), 4 mm (10%), or 5 mm (1%). A large interatrial communication was created in all patients. Modifications of the above surgical technique were applied if required by anatomic variants. Cardiopulmonary bypass time was 141 ± 42 minutes and circulatory arrest time was 57 ± 14 minutes. Secondary sternal closure after the Norwood procedure was frequent.
Postoperative management aimed at achieving balanced systemic and pulmonary blood flow with a pulmonary/systemic flow ratio of 1:1 by ventilatory management. Carbon dioxide was not routinely added in the postoperative treatment. Patients were usually extubated 1 or 2 days after sternal closure.
Further surgical therapy included a bidirectional Glenn anastomosis (stage II) before a fenestrated Fontan operation. At the time of follow-up 106 patients had undergone a bidirectional Glenn shunt and 69 had undergone Fontan palliation. Ages were 7.3 ± 3.3 months at the stage II palliation and 27.7 ± 11.2 months at the third stage and were not significantly different between patients with and without HLHS (P = .50 and P = .62, respectively).
Follow-up and statistical analysis.
Follow-up was conducted by review of the medical records including postoperative visits at Children’s Hospital. If the patient was seen elsewhere, the patient’s physicians or guardians were contacted. Patient outcomes included operative, 1-year, and overall survival. Operative mortality was defined as survival of less than 30 days or in-hospital mortality. Follow-up was complete for operative and 1-year survivors except for 2 patients who were less than 1 year of age at the time of the study.
Differences in the proportion of patients with and without preoperative, postoperative, and anatomic variables were compared by 
2 test. Whenever necessary, the Fisher exact test was used. Z-scores were compared by use of the 2-sample Student t test. Approximate 95% confidence limits for binomial proportions were calculated by the Pratt method. 6 Actuarial survivals were determined and univariable analysis was performed with the Kaplan-Meier product-limit method. Survival curves were compared by the log-rank test. For multivariable analysis, the Cox proportional-hazards regression model was used to establish the variables independently associated with each outcome. Risk ratios and 95% confidence intervals were constructed for the significant multivariable predictors. Final models were derived by the backward stepwise likelihood procedure with variables having P < .20 in the univariable analyses entered as candidates into the Cox model. Statistical analyses was performed with the SAS software package (version 6.12, SAS Institute, Cary, NC).
The following variables were analyzed: preoperative data (age, weight, fetal diagnosis, prematurity, extracardiac anomalies); anatomic characteristics (subgroups of HLHS and non-HLHS, morphology of the ventricle[s]; Z-scores at different levels of the aorta, of the main pulmonary artery, and of the valves; presence of coarctation of the aorta and interrupted aortic arch, restrictive ASD, coronary anomalies, coronary fistulas, and sinusoids); and operative data (surgeon, different surgical techniques with regard to arch reconstruction and establishment of pulmonary blood flow, and cardiopulmonary bypass and circulatory arrest times).
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Results |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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There were 60 operative deaths. Causes for mortality included myocardial ischemia and unbalanced pulmonary and systemic blood flow resulting in ventricular or systemic organ failure or severe hypoxemia. Twenty-six patients died within the first 24 hours after the operation (20/48 HLHS deaths and 6/12 non-HLHS deaths). Autopsy reports were available in 15 of these patients (10 HLHS; 5 non-HLHS); histologic features were compatible with myocardial ischemia in 9 HLHS patients and 1 non-HLHS patient who had an anomalous circumflex coronary artery arising from the pulmonary artery. During the follow-up period, 29 of 134 patients who survived the first-stage palliation died. Causes of late death and the time of their occurrence are described in Table IV. Operative mortality for the bidirectional Glenn procedure was 3.8% (4/106); three of the operative deaths occurred in patients who were under the age of 3 months at the time of stage II surgery (39, 61, and 73 days of age). Mortality for the Fontan operation was 2.8% (2/69). There was no significant difference in mortality for patients with or without HLHS for the stage II and Fontan procedures (P = .99 and P = .15).
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2 test: P = 0.02 and P = .04; Kaplan-Meier analysis: P = .17 and P = .1, respectively; Table V
). There was no significant difference in survival between the anatomic subgroups of the HLHS patients. This finding also applied to the anatomic subgroups of the non-HLHS patients. To test the hypothesis that evolving management of patients undergoing the Norwood operation influenced mortality, we divided the patients according to the date of operation into a group operated on during the first 4 years (1990-1994; n = 109; 83 HLHS and 26 non-HLHS patients) and a group operated on during the second 4 years (1995-1998; n = 85; 48 HLHS and 37 non-HLHS patients) of the study period. Operative survival increased from 61.5% in the first period to 78.6% for patients in the latter period (P = .01, univariate Kaplan-Meier analysis; P = .02, multivariate Cox regression analysis) (Fig 3). Survival improved in the second study period for HLHS patients (P = .04) and did not change for the non-HLHS patients (P = .75).
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One-year survival.
One-year survival was significantly higher for malformations other than typical HLHS (71% vs 51%, 2 analysis, P = .03; Kaplan-Meier, P = .02). Once again, the presence of a well-developed morphologically left ventricle was a predictor for survival in univariate (P < .001) and multivariate analysis (P = .008). Patients with a single right ventricle were estimated to have a risk nearly 5-fold higher for 1-year mortality (risk ratio = 4.8, 95% confidence intervals = 2.0-12.7) (Table V). Prematurity and a restrictive ASD at birth impaired survival (P = .04 and P = .02, respectively, in 2 analysis; P = .02 and P = .20, respectively, in Kaplan-Meier analysis). None of the other variables, including date of operation, correlated with 1-year survival.
During follow-up, 5 patients underwent cardiac transplantation with 2 deaths (Table IV). The 3 survivors had undergone transplantation after the second step (2 patients) and after the Fontan procedure (1 patient); all patients undergoing transplantation were in the HLHS group.
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Discussion |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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7
Early mortality is often due to myocardial ischemia or imbalance of pulmonary and systemic blood flow with subsequent organ failure or hypoxemia. 8 Mortality after initial hospital discharge is not insignificant and reflects the delicately balanced nature of the circulation in patients after the first step of staged palliation.
Several studies have been performed to identify predictors of outcome of the Norwood procedure. Cardiopulmonary bypass time, 9 prerepair pH, lower birth weight and associated noncardiac anomalies, 10 severe obstruction to pulmonary venous return, 11 diminutive ascending aorta, 12 and anatomic subtype, specifically aortic and mitral atresia, 13 have been demonstrated to impair survival in recent studies. None of these risk factors, however, has been consistent across all studies. In contrast to our previous reports, 13 the size of the aortic root and ascending aorta was not a predictor of survival in this series. However, mortality in the first 24 hours after the operation related to myocardial ischemia seemed to be more frequent in HLHS patients.
In our study, prematurity and a restrictive ASD tended to influence operative mortality. With HLHS physiology, restrictive flow across the atrial septum causes pulmonary venous hypertension. Although catheter-directed atrial septoplasty is usually performed shortly after admission, pulmonary vascular resistance may be increased, making the balance between systemic and pulmonary blood flow more difficult to achieve in the early postoperative period. 14,15
We compared the outcome of typical HLHS with that of other malformations with the same pathophysiology and found a greater operative and 1-year survival in the non-HLHS patients. Actuarial survival in HLHS patients was in the same range as that in patients with aortic atresia after staged reconstructive surgery as reported by Jacobs, Blackstone, and Bailey 10 in the multicenter study of the Congenital Heart Surgeons Society (64%, 50%, and 47% after 1, 12, and 36 months). In that report, survival was higher for patients who entered the transplant protocol (85%, 64%, and 62% after 1, 12, and 36 months) and is comparable with that of our non-HLHS patient group.
In our study the presence of a morphologically left ventricle was the most important predictor of survival in this time frame, although this has not been a consistent finding in our previous reports.
In the neonatal period and during the first weeks after birth, the myocardium has the potential for hyperplasia, which represents real growth of muscle cells. 16 This ability may be different between the right and left ventricles, adding to the improved outcome of stage I palliation in newborn infants with anatomically left ventricles. A tricuspid atrioventricular valve with possibly associated abnormalities may also contribute to the limited prognosis of patients with a single right ventricle. 17,18 In the presence of two ventricles with antegrade flow through the aortic valve or a VSD, the left ventricle can contribute to cardiac output, thus decreasing the workload of the right ventricle. Different contraction patterns of a right ventricle during the cardiac cycle in the absence of a second ventricle have recently been described and may also influence outcome. 19
In contrast to our findings, Jacobs and coworkers 20 described a comparable outcome for non-HLHS and HLHS patients. However, they used a different classification of these complex malformations and did not distinguish between patients with right, left, or two ventricles. Kanter and colleagues 21 also applied the Norwood concept successfully to patients with variants of the HLHS. Mosca and associates 22 reported an 89% operative survival for the Norwood procedure in tricuspid atresia or double-inlet right ventricle and transposition of the great arteries with arch anomalies. These patients represent two subsets of our non-HLHS patient group with well-developed left ventricles, confirming its impact on survival. Comparison of the subgroups of the non-HLHS patients in a larger series would help to further determine predictors of survival, which might be eliminated in our analysis by the heterogeneity of malformations.
Some anatomic subsets of the HLHS and non-HLHS patients have been considered potential candidates for a biventricular repair. Tchervenkov and associates 23 selected patients with severe hypoplasia of the left-sided structures but with antegrade flow through the left side of the heart and performed a biventricular repair. Steger and coworkers 24 combined Norwood and Rastelli procedures for interrupted aortic arch with subaortic stenosis. The criteria to opt for a Norwood procedure in complex malformations are not well defined. Systematic analysis of mortality for a two-ventricle approach versus a one-ventricle approach is so far only available for critical aortic stenosis. We consider the possibility of a biventricular repair whenever feasible. However, the mortality for single ventricle palliation after a failed attempt at a two-ventricle repair has been exceedingly high in our experience, possibly because of elevation of pulmonary venous pressure. Thus the decision for a two-ventricle versus a one-ventricle approach must be made accurately early in the neonatal period.
Biventricular repair after a stage I operation and a salvage Norwood procedure to bridge a period of severe left ventricular dysfunction has been discussed. 19 The potential of a hypoplastic left ventricle to grow and the conditions under which this might happen are intriguing. We have so far not observed remarkable growth of a hypoplastic left ventricle in any of our patients after stage I palliation. This may be due at least in part to the presence of an unrestricted interatrial communication and the worse compliance of the hypoplastic left ventricle.
In summary, the findings of our study confirm the validity of the Norwood concept in the treatment of complex cardiac anomalies with good results at intermediate follow-up.
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Appendix: Discussion |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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Over the years, I have found it more awkward to deal surgically with aortopulmonary relations such as aortic atresia with transposition of the great arteries and tricuspid atresia. However, as we evaluated these different anatomic variations in comparison to HLHS treated with a similar palliative operation, we never really noticed a consistent difference between outcomes of those two patient groups.
It is always difficult to discuss a very diverse set of patients, and it is difficult to be sure that one is making meaningful inferences even when our statistical packages encourage us to infer. The principal conclusion that I hear, at least on this group of patients, is that non-HLHS patients fare better than HLHS patients; having some semblance of a left ventricle is advantageous.
My difficulty with such information is that I do not know what to do with it. Do we use it to select patients? Do we strongly consider transplantation when we are dealing with a dominant right ventricle? Or do we simply try harder?
I made a slide comparing some of our data with your data, to address this particular point, but as I read the first paragraph in the discussion of this manuscript, I found the point is made. You state: "HLHS is a lethal anomaly if not treated surgically. The Norwood operation is predominantly an extracardiac procedure that can be applied to a variety of malformations regardless of intracardiac anomalies. The results have improved continuously because of increasing surgical experience and better understanding of the delicate balancing of pulmonary and systemic blood flow in the perioperative period, as well as improvements in techniques of cardiopulmonary bypass in neonates. Operative survival was 69% in our study over a period of 8 years with significant improvement to 79% after 1994. Further improvement has occurred beyond the end point of this study. From January to December 1998, only 1 of 21 patients died after stage I palliation." I do not think the right ventricle is getting stronger. I think you are on the right track. You further state: "A learning curve is expected in the treatment of these challenging patients and is attributed to increasing experience both in surgical and in perioperative management."
Two interesting points came out that I would like to discuss. I am not sure you can come up with a concrete answer to these two questions. I noticed that a group of 11 patients had virtually intact atrial septum or very restrictive atrial septum, and they had cardiac catheterization and balloon manipulation of the atrial septum preoperatively. We have given up trying to deal with the virtually intact atrial septum in the catheterization laboratory because of its relative thickness and the relative smallness of the left atrium. We actually have altered the timing of the operation rather than going to the cardiac catheterization laboratory before surgical intervention. In your 11 patients, do you think it was worthwhile? Did it favorably influence the outcome and the physiology of the patients after the operation?
Second, a number of patients died in the interim between the initial palliation and bidirectional Glenn procedure. We continue to use predominantly a 4-mm tube graft or shunt, and I noticed that you used predominantly a 3.5-mm shunt. What are your thoughts relating to the interim mortality and the size of the shunt? How would that influence the interim mortality? Would it lead patients to an earlier bidirectional Glenn shunt or obviate interim myocardial dysfunction, which is probably even worse than increasing cyanosis?
Dr Daebritz (Boston, Mass). Thank you for your comments. It is interesting that the risk factors for stage I mortality are inconsistent between different studies. A variable that reaches significance in one series does not show an influence in another series. It may be that multiple factors play a role in the stage I mortality or that we are missing a major confounding variable.
We found a difference in survival of our Norwood patients with regard to the underlying anatomy; results of other studies do not confirm this. This might be due to different patient selection, as it is controversial how to define HLHS and where to draw the line to non-HLHS anatomy. Additionally, the group of non-HLHS patients in itself is inhomogeneous, with only small numbers for each anatomic subgroup. Therefore, differences in survival between the subgroups might not be detected by statistical analysis or might be eliminated when comparing the whole group of non-HLHS patients to HLHS patients. Nevertheless, in our series patients with a well-developed left ventricle had a better survival.
What do we do with this information? We do not think we can use it for selecting patients for staged palliation or transplantation. We do think, however, that these results are of importance in borderline patients, in whom a two-ventricle repair is considered an option. We found a good survival for the Norwood palliation in these patients. Attempts at a two-ventricle repair have to compete with these results. A much higher mortality would not be acceptable, although some patients might end up with two-ventricle physiology.
A highly restrictive ASD or a virtually intact atrial septum causes low cardiac output with severe acidosis and pulmonary venous hypertension. We prefer stabilizing the patient before the operation instead of operating with the patient in poor clinical condition. Blade septostomy has been performed but carries a high risk of damaging the free atrial wall. Usually a balloon atrial septoplasty through a separate hole in the atrial septum is successful. In most cases a stable preoperative clinical situation without low output and acidosis can be accomplished with this strategy.
Regarding the shunt sizes, the current policy at Children’s Hospital in Boston is to use 3.5-mm shunts. We think that this creates the best balance between pulmonary and systemic circulation, at least in the early postoperative period. This might change when the patient grows. The interim mortality between stage I and stage II is probably due in part to disturbance of the delicate balance between the two circulations. The bidirectional Glenn shunt leads to a stable relation of pulmonary and systemic blood flow without shunt dependence of pulmonary perfusion. Additionally, volume unloading of the ventricle and higher diastolic systemic pressures with improved coronary perfusion help to preserve myocardial function. After this step, mortality decreases sharply. Therefore, the interim mortality after the stage I operation is related to obstructed flow through the shunt, ventricular dysfunction, or myocardial ischemia. We do not have detailed information about the causes of death in most of the cases, as the patients often die suddenly outside the hospital and autopsies are not available. To find out whether or not shunt size plays a role, we would need a detailed analysis of each patient dying in that time period. However, if shunt size was the major cause of this interim mortality, one would expect to find series with no significant mortality between the first two stages. These do not yet exist. Probably the balanced perfusion of body and lung under Norwood stage I physiology is so delicate that it can be disturbed by common conditions like respiratory and pulmonary infections or fever.
It might be reasonable to try to decrease this mortality by performing the bidirectional Glenn shunt earlier after the stage I procedure, for example, with an interval of 3 months. The 3 patients in our series who had a Glenn shunt at an age of less than 3 months and who died did not have a shunt-dependent pulmonary perfusion for 3 months. In these patients, severe imbalance of pulmonary and systemic blood flow or myocardial dysfunction forced the surgeon to perform the Glenn shunt very early after the stage I procedure. Performing an elective Glenn operation 3 months after stage I with the patient in good clinical condition might improve the results.
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Footnotes |
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References |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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 A. A. Kon, L. Ackerson, and B. Lo How Pediatricians Counsel Parents When No "Best-Choice" Management Exists: Lessons to Be Learned From Hypoplastic Left Heart Syndrome Arch Pediatr Adolesc Med, May 1, 2004; 158(5): 436 - 441. [Abstract] [Full Text] [PDF]
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T. Nakano, H. Kado, Y. Shiokawa, K. Fukae, Y. Nishimura, K. Miyamoto, Y. Tanoue, H. Tatewaki, and N. Fusazaki The low resistance strategy for the perioperative management of the Norwood procedure Ann. Thorac. Surg., March 1, 2004; 77(3): 908 - 912. [Abstract] [Full Text] [PDF]
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S. M. Bradley, A. M. Atz, and J. M. Simsic Redefining the impact of oxygen and hyperventilation after the Norwood procedure J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 473 - 480. [Abstract] [Full Text] [PDF]
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K. O. Maher, C. Pizarro, S. S. Gidding, K. Januszewska, E. Malec, W. I. Norwood Jr, and J. D. Murphy Hemodynamic Profile After the Norwood Procedure With Right Ventricle to Pulmonary Artery Conduit Circulation, August 19, 2003; 108(7): 782 - 784. [Abstract] [Full Text] [PDF]
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S. Sano, K. Ishino, M. Kawada, S. Arai, S. Kasahara, T. Asai, Z.-i. Masuda, M. Takeuchi, and S.-i. Ohtsuki Right ventricle-pulmonary artery shunt in first-stage palliation of hypoplastic left heart syndrome J. Thorac. Cardiovasc. Surg., August 1, 2003; 126(2): 504 - 510. [Abstract] [Full Text] [PDF]
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D. A. Ashburn, B. W. McCrindle, C. I. Tchervenkov, M. L. Jacobs, G. K. Lofland, E. L. Bove, T. L. Spray, W. G. Williams, and E. H. Blackstone Outcomes after the Norwood operation in neonates with critical aortic stenosis or aortic valve atresia J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1070 - 1082. [Abstract] [Full Text] [PDF]
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S. M. Bradley, J. M. Simsic, A. M. Atz, and B. H. Dorman The infant with single ventricle and excessive pulmonary blood flow: results of a strategy of pulmonary artery division and shunt Ann. Thorac. Surg., September 1, 2002; 74(3): 805 - 810. [Abstract] [Full Text] [PDF]
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J. W. Gaynor, W. T. Mahle, M. I. Cohen, R. F. Ittenbach, W. M. DeCampli, J. M. Steven, S. C. Nicolson, and T. L. Spray Risk factors for mortality after the Norwood procedure Eur J Cardiothorac Surg, July 1, 2002; 22(1): 82 - 89. [Abstract] [Full Text] [PDF]
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C. Pizarro, D. A. Davis, M. E. Galantowicz, H. Munro, S. S. Gidding, and W. I. Norwood Stage I palliation for hypoplastic left heart syndrome in low birth weight neonates: can we justify it? Eur J Cardiothorac Surg, April 1, 2002; 21(4): 716 - 720. [Abstract] [Full Text] [PDF]
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J. M. Pearl, D. P. Nelson, S. M. Schwartz, and P. B. Manning First-stage palliation for hypoplastic left heart syndrome in the twenty-first century Ann. Thorac. Surg., January 1, 2002; 73(1): 331 - 339. [Abstract] [Full Text] [PDF]
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B. W. Duncan, G. L. Rosenthal, T. K. Jones, and F. M. Lupinetti First-stage palliation of complex univentricular cardiac anomalies in older infants Ann. Thorac. Surg., December 1, 2001; 72(6): 2077 - 2080. [Abstract] [Full Text] [PDF]
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S. M. Bradley, J. M. Simsic, and A. M. Atz Hemodynamic effects of inspired carbon dioxide after the Norwood procedure Ann. Thorac. Surg., December 1, 2001; 72(6): 2088 - 2093. [Abstract] [Full Text] [PDF]
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A. Azakie, S. L. Merklinger, B. W. McCrindle, G. S. Van Arsdell, K.-J. Lee, L. N. Benson, J. G. Coles, and W. G. Williams Evolving strategies and improving outcomes of the modified Norwood procedure: a 10-year single-institution experience Ann. Thorac. Surg., October 1, 2001; 72(4): 1349 - 1353. [Abstract] [Full Text] [PDF]
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F. A. Pigula, S. K. Gandhi, R. D. Siewers, P. J. Davis, S. A. Webber, and E. M. Nemoto Regional low-flow perfusion provides somatic circulatory support during neonatal aortic arch surgery Ann. Thorac. Surg., August 1, 2001; 72(2): 401 - 407. [Abstract] [Full Text] [PDF]
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E. A. Bacha, M. Almodovar, D. L. Wessel, D. Zurakowski, J. E. Mayer Jr, R. A. Jonas, and P. J. del Nido Surgery for coarctation of the aorta in infants weighing less than 2 kg Ann. Thorac. Surg., April 1, 2001; 71(4): 1260 - 1264. [Abstract] [Full Text] [PDF]
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N. C. Poirier, J. J. Drummond-Webb, K. Hisamochi, M. Imamura, A. M. Harrison, and R. B. B. Mee Modified Norwood procedure with a high-flow cardiopulmonary bypass strategy results in low mortality without late arch obstruction J. Thorac. Cardiovasc. Surg., November 1, 2000; 120(5): 875 - 884. [Abstract] [Full Text] [PDF]
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