J Thorac Cardiovasc Surg 2001;121:597
© 2001 The American Association for Thoracic Surgery
Letters to the Editor
Kokura Memorial Hospital
Kitakyushu-shi 802-8555, Japan
bAssistant Professor II
Department of Physiology
The University of Ryukyus School of Medicine
To the Editor:
We do not doubt the protective effects of Na+ channel blockade, but Anttila and associates 1 have failed to interpret their own data, despite having made the statistical analysis and found significant changes. Discussing significant findings is the least we can ask even if the interpretation reached may not be agreeable to everybody. Failing to discuss findings is worse than jumping to conclusions without analyzing statistically. We will not repeat here their two grave omissions.
Had they properly interpreted their findings, they should have reached the conclusion that something was wrong in the induction of hypothermia itself besides the protective effects of lamotrigine. We believe the effects of proper pH management are far greater than those provided by lamotrigine, riluzole, or memantine, and pH-stat strategies should be re-appraised with modern technology based on actual experimentation and not computer simulations, as advocated by some groups.
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