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J Thorac Cardiovasc Surg 2001;121:598-599
© 2001 The American Association for Thoracic Surgery

Letters to the Editor

Oxidative stress during cardiopulmonary bypass

Tadaomi-Alfonso Miyamoto, MD a, Koho-Julio Miyamoto, MD, PhD b

aResearch Department
Kokura Memorial Hospital
1-1 Kifune-cho
Kokura-kitaku
Kitakyushu-shi 802-8555, Japan

bAssistant Professor II
Department of Physiology
The University of Ryukyus School of Medicine
Okinawa, Japan

To the Editor:

We do not doubt that oxidative stress is induced by cardiopulmonary bypass whether in patients with diabetes or in those without diabetes. Although not specified in the article by Matata and Galiñanes,Go 1 alpha-stat mild hypothermia must have been used. The increased oxidative stress in persons with diabetes might be indicating their greater sensitivity to the hypothermia-induced Bohr effect or tissular hypoxia, resulting in oxidative stress beyond the capabilities of endogenous nitric oxide to counteract but still responsive to exogenous nitric oxide. If exogenous nitric oxide donors had no effect in patients without diabetes, the reason might be that endogenous nitric oxide is effective enough that exogenous nitric oxide adds no benefit.

12/8/113012

doi:10.1067/mtc.2001.113012

References

  1. Matata BM, Galiñanes M. Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide. J Thorac Cardiovasc Surg 2000;120:1-11.[Abstract/Free Full Text]




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