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J Thorac Cardiovasc Surg 2001;121:598-599
© 2001 The American Association for Thoracic Surgery

Letters to the Editor

Which cell does heat shock protein 72 induce?

Masahiro Sakurai, MD, Koji Abe, MD, PhD, Koichi Tabayashi, MD, PhD

Department of Cardiovascular Surgery
Tohoku University Graduate School of Medicine
1-1, Seiryo-machi, Aoba-ku
Sendai 980-8574, Japan

To the Editor:

We read with interest the article by de Haan and associatesGo 1 on heat shock protein 72 (HSP 72). We agree that ischemic pretreatment could not induce tolerance to a severe (26 minutes) spinal cord ischemic insult. However, we have one question. The authors have not demonstrated whether HSP 72 was induced in motor neurons or not. In experimental models of spinal cord ischemia, the main topic has been believed to be the selective vulnerability of motor neurons. Therefore, histologic study is important. Some researchers have counted the number of motor neurons after spinal cord ischemia.Go Go 2,3 The authors demonstrated that 15 minutes of spinal cord ischemia was considerably shorter than de Haan's ischemic models (26 minutes). However, our previous report has demonstrated selective motor neuron death after 15 minutes of spinal cord ischemia, and HSP 72 messenger RNA and protein were induced only in motor neurons.Go 4 Our result revealed that HSP 72 messenger RNA and protein were induced as a set of markers of "neuronal injury" after ischemia. The authors did not say whether HSP 72 was a marker of neuronal injury or a molecular chaperone. Therefore, they should demonstrate temporal profiles of HSP 72 in a histochemical study or an in situ hybridization study.

12/8/113172

doi:10.1067/mtc.2001.113172

References

  1. de Haan P, Vanicky I, Jacobs MJHM, Bakker O, Lips J, Meylaerts SAG, Kalkman CJ. Effect of ischemic pretreatment on heat shock protein 72, neurologic outcome, and histopathologic outcome in a rabbit model of spinal cord ischemia. J Thorac Cardiovasc Surg 2000;120:513-9.[Abstract/Free Full Text]
  2. Mutch WAC, Graham MR, Halliday WC, Teskey JM, Thomson IR. Paraplegia following thoracic aortic cross-clamping in dogs: no difference in neurological outcome with a barbiturate versus isoflurane. Stroke 1993;24:1554-60.[Abstract/Free Full Text]
  3. Matsumoto M, Iida Y, Sakabe T, Sano T, Ishizawa T, Nakakimura K. Mild and moderate hypothermia provide better protection than a burst-suppression dose of thiopental against ischemic spinal cord injury in rabbits. Anesthesiology 1997;86:1120-7.[Medline]
  4. Sakurai M, Aoki M, Abe K, Sadahiro M, Tabayashi K. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 1997;113:159-64.[Abstract/Free Full Text]




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