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J Thorac Cardiovasc Surg 2001;121:599
© 2001 The American Association for Thoracic Surgery

Letters to the Editor

Reply

P. de Haan, MD, PhD

Department of Anesthesiology
Academic Medical Center
Amsterdam, The Netherlands

Reply to the Editor:

A temporary period of ischemia might induce beneficial mechanisms that may result in a "preconditioned state." The role of heat shock protein (HSP) in ischemic preconditioning is unclear. The aim of our study was not to assess whether HSP is a molecular chaperone that may play a role in the acquisition of ischemic tolerance or whether HSPs are merely an epiphenomenon of (sub)lethal neuronal injury. In our article, HSP 72 was used to assess whether the preconditioning stimulus was sufficiently severe to induce a neuronal response.Go 1 Indeed, HSP was not measured in the anterior horn motor neuron. However, the motor neuron is the spinal cord structure most susceptible to ischemia, and the motor neurons selectively produce HSP after transient ischemia.Go 2 Therefore, in situ hybridization to identify the neuron responsible for HSP production is probably a redundant measurement.

12/8/113173

doi:10.1067/mtc.2001.113173

References

  1. de Haan P, Vanicky I, Jacobs MJ, Bakker O, Lips J, Meylaerts SA, et al. Effect of ischemic pretreatment on heat shock protein 72, neurologic outcome, and histopathologic outcome in a rabbit model of spinal cord ischemia. J Thorac Cardiovasc Surg 2000;120:513-9.[Abstract/Free Full Text]
  2. Sakurai M, Aoki M, Abe K, Sadahiro M, Tabayashi K. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 1997;113:159-64.[Abstract/Free Full Text]



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