JTCS Tips for Better Browsing
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
David T. Lai
D. Craig Miller
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Timek, T. A.
Right arrow Articles by Miller, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Timek, T. A.
Right arrow Articles by Miller, D. C.
Related Collections
Right arrow Valve disease

J Thorac Cardiovasc Surg 2002;123:881-888
© 2002 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease (ACD)

Septal-lateral annular cinching abolishes acute ischemic mitral regurgitation

Tomasz A. Timek, MDa, David T. Lai, FRACSa, Frederick Tibayan, MDa, David Liang, MD, PhDb, George T. Daughters, MSa,c, Paul Dagum, MD, PhDa, Neil B. Ingels, Jr, PhDa,c, D. Craig Miller, MDa

From the Department of Cardiovascular Surgerya and the Division of Cardiovascular Medicine,b Stanford University School of Medicine, Stanford, Calif, and the Laboratory of Cardiovascular Physiology and Biophysics,c Research Institute of the Palo Alto Medical Foundation, Palo Alto, Calif.

Supported by grants HL-29589 and HL-67025 from the National Heart, Lung, and Blood Institute. Drs Timek, Tibayan, Dagum, and Lai are Carl and Leah McConnell Cardiovascular Surgical Research Fellows. Drs Timek, Tibayan, and Dagum were supported by National Heart, Lung, and Blood Institute Individual Research Service Awards HL-10452, HL-67563, and HL-10000, respectively. Dr Timek was also a recipient of the Thoracic Surgery Foundation Research Fellowship Award. Dr Lai was supported by a fellowship from the American Heart Association, Western States Affiliate.

Received for publication May 15, 2001. Revisions requested July 13, 2001; revisions received Dec 4, 2001. Accepted for publication Dec 12, 2001. Address for reprints: D. Craig Miller, MD, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305-5247 (E-mail: dcm{at}stanford.edu).


   Abstract
Top
 Abstract
Introduction
 Methods
 Results
 Discussion
 Appendix: Discussion
 References
 
Objective: Ring annuloplasty prevents acute ischemic mitral regurgitation in sheep, but it also abolishes normal mitral annular and posterior leaflet dynamics. We investigated a novel surgical approach of simple septal-lateral annular cinching with sutures to treat acute ischemic mitral regurgitation.
Methods: Nine adult sheep underwent implantation of multiple radiopaque markers on the left ventricle, mitral anulus, and mitral leaflets. A septal-lateral transannular suture was anchored to the midseptal mitral anulus and externalized to a tourniquet through the midlateral mitral anulus and left ventricular wall. Open-chest animals were studied immediately postoperatively. Acute ischemic mitral regurgitation was induced by means of proximal left circumflex artery snare occlusion, and 3 progressive steps of septal-lateral annular cinching (each 2-3 mm suture tightening for 5 seconds) were performed with the transannular suture. Biplane videofluoroscopy for 3-dimensional marker coordinates and transesophageal echocardiography were performed continuously before and during left circumflex ischemia and septal-lateral annular cinching.
Results: Acute left circumflex ischemia caused ischemic mitral regurgitation (+0.5 ± 0.4 [baseline] vs +2.0 ± 0.7 [ischemia]; P = .005; scale, +0-4), which decreased progressively with each step of septal-lateral annular cinching and was eliminated during the third step (ischemic mitral regurgitation, +0.6 ± 0.5; P = not significant vs baseline). The third step of septal-lateral annular cinching decreased the septal-lateral diameter by 6.0 ± 2.6 mm (P = .005); however, mitral anulus area reduction (8.5% ± 1.0% and 6.9% ± 1.9% for ischemic mitral regurgitation and septal-lateral annular cinching step 3, respectively; P = .006) and posterior leaflet excursion (50° ± 9° and 44° ± 11° for regurgitation and annular cinching step 3, respectively; P = .002) throughout the cardiac cycle were affected only mildly. Normal mitral annular 3-dimensional shape was maintained with septal-lateral annular cinching.
Conclusions: Isolated 22% ± 10% reduction in mitral annular septal-lateral dimension abolished acute ischemic mitral regurgitation in normal sheep hearts while allowing near-normal mitral annular and posterior leaflet dynamic motion. Septal-lateral annular cinching may represent a simple method for the surgical treatment of ischemic mitral regurgitation, either as an adjunctive technique or alone, which helps preserve physiologic annular and leaflet function.


   Introduction
Top
 Abstract
 Introduction
Methods
 Results
 Discussion
 Appendix: Discussion
 References
 
Ischemic mitral regurgitation (IMR) continues to frustrate surgeons because neither its mechanism nor an ideal surgical therapy has been clearly defined. MR caused by ischemic heart disease is associated with a far less satisfactory prognosis than other forms of mitral disease.Go Go 1-3 Although mitral valve repair, usually consisting of simple ring annuloplasty, has been associated with more encouraging results in this challenging patient cohort,Go Go 4,5 the superiority of valve repair over valve replacement has yet to be firmly established.Go Go 6,7 Unfortunately, only approximately 50% of patients are still alive at 5 years, primarily because of left ventricular (LV) dysfunction present at the time of the operation caused by previous LV infarction and ischemia. Mitral ring annuloplasty has been demonstrated to effectively correct IMR in clinicalGo Go 7-9 and experimentalGo 10 studies, most likely by facilitating leaflet coaptation through reduction of the annular septal-lateral (SL; or clinically termed anteroposterior) dimension.Go 10 On the other hand, ovine experiments have shown that ring annuloplasty, whether semirigid or flexible, abolishes normal mitral annular dynamicsGo 11 and freezes the posterior mitral leaflet.Go 12 Limited posterior leaflet excursion after implantation of a rigid annuloplasty ring has also been reported in a porcine modelGo 13 and clinically is seen often after any type of annuloplasty.

We developed a novel technique of SL annular reduction using a simple transannular suture to enhance leaflet coaptation while avoiding the deleterious effects of ring annuloplasty on annular and leaflet dynamic motion. By using radiopaque marker technology, we carried out a preliminary investigation of the efficacy of septal-lateral annular cinching (SLAC) in an open-chest sheep preparation during acute posterolateral ischemia.


   Methods
Top
 Abstract
 Introduction
 Methods
Results
 Discussion
 Appendix: Discussion
 References
 
Surgical preparation
Nine adult sheep were used in the study. The operative procedure for marker implantation has been described previously in detail.Go 14 The markers were implanted on the left ventricle, around the mitral anulus, and on the central edge of each leaflet, as shown in Figure 1. A single 4-0 Prolene suture (Ethicon, Inc, Somerville, NJ) was anchored with Teflon felt pledgets at the midseptal (or anterior) anulus (annular saddle horn) and externalized through the midlateral (or posterior) anulus to a tourniquet on the epicardial surface (Figure 2). After completion of marker implantation, a silicone rubber loop was placed around the proximal left circumflex coronary artery for induction of posterolateral ischemia and IMR. Subsequently, the heart was defibrillated, and the animal was weaned from cardiopulmonary bypass and transferred immediately to the experimental animal catheterization laboratory, where the animals were studied while intubated with an open chest and anesthetized with ketamine (1-4 mg · kg-1 · h-1 intravenous infusion) and diazepam (5 mg intravenous bolus as needed). Intravenous esmolol infusion (20-50 µg - kg-1 · min-1) was used to minimize reflex sympathetic responses. Simultaneous biplane videofluoroscopy, hemodynamic data, and transesophageal color Doppler echocardiography were recorded continuously during acute occlusion of the proximal circumflex artery (IMR) and 3 progressive steps of SLAC (SLAC-1, SLAC-2, and SLAC-3; each step being roughly 2-3 mm more suture tightening than the previous step and held for approximately 5 seconds).



View larger version (20K):
[in this window]
[in a new window]
  		Fig. 1. Array of LV (circles), mitral annular (squares), and leaflet (triangles) markers used in this ovine experiment. AML, Anterior mitral leaflet; PML, posterior mitral leaflet.

 


View larger version (24K):
[in this window]
[in a new window]
  		Fig. 2. Schematic illustration of the mitral valve with annular (squares) and leaflet (triangles) markers and the aortic valve included for orientation. SLAC suture (dashed line) spans the annular SL dimension and was externalized to an epicardial tourniquet. Arrow shows the direction of annular cinching. AV, Aortic valve; ACOM, anterior commissure; PCOM, posterior commissure; AML, anterior mitral leaflet; PML, posterior mitral leaflet.

 
All animals received humane care in compliance with the "Principles of Laboratory Animal Care" formulated by the National Society for Medical Research and the "Guide for the Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources, National Research Council, and published by the National Academy Press, revised 1996. This study was approved by the Stanford Medical Center Laboratory Research Animal Review committee and conducted according to Stanford University policy.

Data acquisition and analysis
Data acquisition,Go 14 digital transformation,Go 15 and 3-dimensional reconstructionGo 16 were performed as described previously. Two to 3 consecutive steady-state beats during IMR and each of the 3 steps of SLAC were designated as IMR, SLAC-1, SLAC-2, and SLAC-3 data for each animal, respectively. For each cardiac cycle, end-systole was defined as the frame containing the peak rate of fall of LV pressure (-dP/dt), and end-diastole as the videofluoroscopic frame containing the peak of the electrocardiographic R wave. Instantaneous LV volume was computed from the epicardial LV markers by using a space-filling multiple tetrahedral volume method.Go 17 MR was graded subjectively by an experienced cardiologist (D.L.) according to the extent and width of the regurgitant jet and categorized as none (0), mild (+1), moderate (+2), moderate to severe (+3), or severe (+4).

Mitral annular dynamics
Mitral annular area was computed from the 3-dimensional coordinates of the 8 markers sutured to the mitral anulus by using an annular centroid.Go 10 The SL annular diameter was calculated as the distance in 3-dimensional space between markers placed on the midseptal and midlateral mitral anulus, and the commissure-commissure (CC) diameter was determined as the distance between the markers on the anterior and posterior commissures. Angular position of the anterior leaflet edge was calculated as the angle ({theta}AML) between the anterior leaflet edge marker and the SL annular diameter.Go 18 Posterior leaflet edge angular position ({theta}PML) was calculated in similar fashion. Leaflet excursion was calculated from diastolic maximum to systolic minimum angle. For 3-dimensional reconstruction of mitral annular shape, a right-handed Cartesian coordinate system was used with the origin located at the midseptal anulus marker, with the Y-axis passing through the LV apex (positive toward the apex), with the positive X axis directed toward the midlateral anulus such that the midlateral marker was contained in the X-Y plane, and with the positive Z-axis directed toward the posterior commissure. The midseptal anulus was chosen as the origin because it is at the center of the fibrous anulus, the position and geometry of which are minimally affected by posterolateral LV ischemia.

Statistical analysis
All data are reported as means ± 1 SD. Hemodynamic and marker-derived data from consecutive steady-state beats from each heart were time aligned at end-diastole. Marker data were calculated over 20 frames before and after end-diastole, thus allowing evaluation over a time period of 650 ms. The mean and SD for each variable at each sampling instant were computed for each condition. Data were compared by using repeated-measures analysis of variance, followed by the Student t test for paired observations when a significant F value was detected.


   Results
Top
 Abstract
 Introduction
 Methods
 Results
Discussion
 Appendix: Discussion
 References
 
Hemodynamics
The average weight of the animals used in the study was 65 ± 5 kg (±1 SD). The mean cardiopulmonary bypass time was 80 ± 9 minutes, and the mean aortic crossclamp time was 60 ± 7 minutes. Group mean hemodynamic parameters before and after induction of acute posterolateral ischemia are shown in Table 1. Peak LV dP/dt and LV pressure decreased, whereas LV end-diastolic and end-systolic volumes and end-diastolic pressure increased with proximal circumflex occlusion and IMR. No further statistically significant change in hemodynamic parameters was observed during continued ischemia and the SLAC steps, as shown in Table 2.


View this table:
[in this window]
[in a new window]
  		Table 1. Hemodynamics
 

View this table:
[in this window]
[in a new window]
  		Table 2. SLAC hemodynamics
 
Mitral regurgitation
Before circumflex occlusion, 3 animals had mild MR, 3 had trace MR, and 3 had no MR for a baseline average of +0.5 ± 0.4. The significant increase in the mean degree of MR during acute posterolateral ischemia and subsequent decreases with SLAC steps are summarized in Table 3. IMR was mostly central and holosystolic during circumflex occlusion. The final step of annular cinching completely abolished IMR because there was no difference in the degree of MR between SLAC-3 and the baseline value (+0.6 ± 0.5 and +0.5 ± 0.4, P = .6).


View this table:
[in this window]
[in a new window]
  		Table 3. Mitral leaflet and annular dynamics
 
Mitral annular dynamics
Group mean data for mitral annular area and SL and CC diameters are tabulated in Table 3Go and shown in Figure 3. Progressive annular SL reduction was accompanied by a corresponding reduction in mitral annular area and MR, with a small but significant increase in the mitral CC diameter during each SLAC step. During SLAC-3, a 22% ± 10% SL reduction was associated with reduction of MR to preischemic levels. To abolish MR completely, however, the SL diameter had to be reduced to below its preischemic size (Figure 3Go). SLAC-3 reduction resulted in a 14% ± 7% decrease in total annular area, but annular area reduction throughout the cardiac cycle was only modestly smaller; thus, the dynamics of the anulus were reasonably well preserved. The 3-dimensional mitral annular geometry at end-diastole for IMR and SLAC steps is reconstructed in Figure 4. SLAC reduced the SL diameter by approximating the midlateral anulus (along with, to a lesser extent, the adjacent lateral annular segments) to the midseptal anulus. The mitral anulus maintained its saddle shape during IMR and SLAC.



View larger version (36K):
[in this window]
[in a new window]
  		Fig. 3. Group mean data for SL annular diameter (in millimeters, top), mitral annular area (in square millimeters, center), and CC annular diameter (in millimeters, bottom) throughout the cardiac cycle before (pre-IMR) and during acute IMR and progressive SLAC (SLAC-1, SLAC-2, and SLAC-3). A 650-ms time interval centered at end-diastole (t = 0) is illustrated for all 4 groups.

 


View larger version (31K):
[in this window]
[in a new window]
  		Fig. 4. Left, Group mean 3-dimensional reconstruction of the mitral anulus at end-diastole during acute IMR and subsequent progressive SLAC (SLAC-1, SLAC-2, and SLAC-3). Drop lines are shown for IMR and SLAC-3 data points in the apical-basal and SL planes as solid (IMR) and dashed (SLAC-3) lines. Right, Rotated view of each reconstruction to the approximate level of the annular plane viewed from the lateral to septal anulus to illustrate the 3-dimensional shape of the anulus. ACOM, Anterior commissure; PCOM, posterior commissure.

 
Mitral leaflet dynamics
Group mean anterior and posterior leaflet edge angles during the cardiac cycle during IMR and SLAC are shown in Figure 5, with leaflet excursion, from diastolic maximum to systolic minimum, summarized in Table 3Go. There was no change in anterior leaflet excursion during progressive SLAC compared with IMR. Although posterior leaflet excursion was significantly decreased with SLAC-3, this decrease was only by 6° ± 4°, indicating that only a slight limitation of posterior leaflet motion was associated with this technique of annular SL reduction.



View larger version (26K):
[in this window]
[in a new window]
  		Fig. 5. Group mean data for angular displacement of the anterior mitral leaflet (top) and posterior mitral leaflet (bottom) throughout the cardiac cycle before (pre-IMR) and during acute IMR and progressive SLAC (SLAC-1, SLAC-2, and SLAC-3). Leaflet edge angular displacement was calculated with respect to the line between the midseptal and midlateral anulus. A 650-ms time window centered at end-diastole (t = 0) is shown.

 

   Discussion
Top
 Abstract
 Introduction
 Methods
 Results
 Discussion
Appendix: Discussion
 References
 
IMR remains a challenging entity for surgeons. The valve is morphologically and structurally normal, but myocardial injury and dysfunction inherent in the pathophysiology of IMR adversely influence postoperative outcome.Go 4 Ring annuloplasty can effectively correct IMR in many patients,Go Go 7,8 but complete or partial, flexible or rigid annuloplasty rings abolish normal annularGo 11 and posterior leaflet dynamic motion.Go 12 In the current ovine experiment, SLAC with a simple transannular suture abolished acute IMR without markedly perturbing normal mitral annular dynamics and posterior leaflet motion.

Previous ovine experiments have suggested that annular dilatation may be the chief mechanism of acute IMR,Go 19 although other experimental studies have identified changes in subvalvular geometry as playing the primary role in the genesis of IMR.Go Go 20-22 Ring annuloplasty prevents acute IMR in normal sheep by facilitating leaflet coaptation through reduction of the annular SL (anterior-posterior in clinical jargon) dimensionGo 10 because this is the principal direction of annular enlargement during acute left circumflex artery ischemia.Go Go Go 19,23,24 Annular enlargement caused by CC diameter increase, on the other hand, does not seem to lead to MR,Go 25 and in the current experiment a slight increase in CC diameter was actually observed with SLAC. Conversely, ring annuloplasty has also been shown to attenuate apical leaflet tethering in acute ovine IMR,Go 26 suggesting an influence on the subvalvular apparatus. It is possible that SLAC abolished IMR by altering subvalvular geometry, although annular SL reduction leading to improved leaflet coaptation is more likely the predominant mechanism. Central MR during myocardial ischemia, as seen in the current study, is more likely to be associated with annular dilatation,Go 27 and it is therefore not surprising that reduction of the annular SL dimension would correct this type of IMR. Clinically, surgical therapy designed to increase leaflet coaptation, such as implantation of an undersized ring annuloplasty, is usually effective in ameliorating MR in patients with advanced dilated cardiomyopathy, either idiopathic or ischemic.Go 28 Furthermore, the extent of annular SL reduction may be a determinant of operative success in patients with IMR undergoing valve repair.Go 8 Any technique that reduces the size of the mitral anulus, however, also changes the 3-dimensional geometric relationships between the anulus and subvalvular apparatus because these structures are tightly coupled.Go 29 Perhaps restoration of this perturbed relationship partially accounts for the efficacy of SLAC in this ovine model of acute IMR.

SLAC effectively abolished IMR, but this novel technique only mildly altered normal mitral annular geometry and dynamic motion. The 6-mm annular SL reduction with SLAC-3 is comparable with the degree of annular reduction needed to prevent IMR with either a flexible or semirigid annuloplasty ring,Go 10 but SLAC-3 reduced end-diastolic annular area by only 14%, which is considerably less than the 30% to 35% annular area reduction associated with annuloplasty rings.Go 11 Even though annular area was significantly smaller with SLAC, the magnitude of this decrease was modest; perhaps it is smaller total annular size reduction that permits continued dynamic motion of the anulus in SLAC. Annular flexibility serves a dual role by aiding LV filling in diastole and by facilitating leaflet coaptation in late diastole-early systole by virtue of its sphincteric action.Go 30 Therefore, preservation of annular flexibility may have physiologic advantages, yet ring annuloplasty generally minimizes dynamic area change.Go 11 Although SLAC substantially decreased annular SL diameter and mitral area, the 3-dimensional saddle shape of the anulus remained intact, with elevation of the midseptal anulus (or saddle horn) above the annular plane. Recent finite-element analysis of annular shape suggests that this saddle-shaped configuration may have important implications for reducing systolic stress on the valve leaflets.Go 31

Perturbed posterior leaflet motion has been observed after implantation of an annuloplasty ring in animal modelsGo Go 12,13 and is frequently observed clinically on postoperative echocardiography. Indeed, annuloplasty rings, whether flexible or semirigid, freeze the motion of the posterior leaflet, effectively converting the mitral valve into a single leaflet valve.Go 12 Although SLAC inhibited posterior leaflet excursion modestly, the posterior leaflet remained mobile. Whether maintained posterior leaflet motion offers an advantage in terms of effectiveness or durability of valve repair remains to be determined. This could possibly distribute systolic closing stresses more favorably in a bileaflet valve, but further studies are needed to answer this question.

This experiment assessed a novel technique to reduce mitral annular SL dimension to enhance leaflet coaptation and correct IMR in an ovine model of acute ischemia. Progressive SLAC decreased MR because the SL diameter was cinched smaller, yet annular dynamics and posterior leaflet motion were only modestly affected. SLAC potentially represents an expedient and simple surgical method for the treatment of IMR, either alone or as an adjunctive technique.

Although SLAC was effective in abolishing IMR in this experiment, this model of acute IMR is distinctly different than the clinical situation consisting of chronic MR and LV dilatation and systolic dysfunction, which makes clinical extrapolation difficult. The above findings can only be interpreted in the setting of acute LV ischemia in a normal sheep heart under open-chest conditions. These observations cannot be applied to patients with chronic IMR under closed-chest conditions in which subvalvular geometric perturbations may play a more predominant role in the pathogenesis of MR. We are currently exploring a protocol of chronic ovine IMR to validate the efficacy of SLAC in a more clinically relevant setting. Nonetheless, these preliminary findings can provide valuable surgical insight into the mechanisms and treatment of IMR and serve as a foundation for future studies. The myocardial marker method requires suturing small metal markers to intracardiac structures, but echocardiographic studies suggest that the markers do not interfere with mitral annular or leaflet motion because they are very small (aggregate mass = 20 ± 6 mg). Although there are many limitations inherent in this particular animal model, reliable models of cardiac pathophysiology have been established in ovine models.Go Go 32,33


   Appendix: Discussion
Top
 Abstract
 Introduction
 Methods
 Results
 Discussion
 Appendix: Discussion
References
 
Dr Irving L. Kron (Charlottesville, Va). Dr Timek, the mechanism you have created obviously is an acutely ischemic model, and this is a very interesting approach. I know your laboratory knows more about IMR than probably anyone on earth. The typical patient, obviously, has some retraction of the posterior leaflets, some scarring, annular dilatation, and such. Would this technique or some adaptation of it work in those situations, do you think?

Dr Timek. Thank you for that question. That is a very good point. This is an acute model in healthy, normal sheep, and therefore it does not reflect the clinical situation, where chronic changes and volume overload are present. However, this model gives us some insight into the mechanisms of IMR. We are currently working on a model of chronic ovine IMR, and we will try to investigate this method in that setting, which will be more clinically pertinent.


   Acknowledgments
 
We appreciate the superb technical assistance provided by Mary K. Zasio, BA, Carol W. Mead, BA, and Maggie Brophy, AS.


   Footnotes
 
Read at the Eighty-first Annual Meeting of The American Association for Thoracic Surgery, San Diego, Calif, May 6-9, 2001. Back


   References
Top
 Abstract
 Introduction
 Methods
 Results
 Discussion
 Appendix: Discussion
 References
 

  1. Czer LS, Gray RJ, DeRobertis MA, Bateman TM, Stewart ME, Chaux A, et al. Mitral valve replacement: impact of coronary artery disease and determinants of prognosis after revascularization. Circulation. 1984;70(Suppl):I-198-207.
  2. Connolly MW, Gelbfish JS, Jacobowitz IJ, Rose DM, Mendelsohn A, Cappabianca PM, et al. Surgical results for mitral regurgitation from coronary artery disease. J Thorac Cardiovasc Surg. 1986;91:379-88.[Abstract]
  3. Replogle RL, Campbell CD. Surgery for mitral regurgitation associated with ischemic heart disease: results and strategies. Circulation. 1989;79(Suppl):I-122-5.
  4. Dion R. Ischemic mitral regurgitation: when and how should it be corrected? J Heart Valve Dis. 1993;2:536-43.[Medline]
  5. Rankin JS, Feneley MP, Hickey MS, Muhlbaier LH, Wechsler AS, Floyd RD, et al. A clinical comparison of mitral valve repair versus valve replacement in ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 1988;95:165-77.[Abstract]
  6. Hausmann H, Siniawski H, Hetzer R. Mitral valve reconstruction and replacement for ischemic mitral insufficiency: seven years' follow up. J Heart Valve Dis. 1999;8:536-42.[Medline]
  7. Cohn LH, Rizzo RJ, Adams DH, Couper GS, Sullivan TE, Collins JJ, et al. The effect of pathophysiology on the surgical treatment of ischemic mitral regurgitation: operative and late risks of repair versus replacement. Eur J Cardiothorac Surg. 1995;9:568-74.[Abstract]
  8. Czer LS, Maurer G, Trento A, DeRobertis M, Nessim S, Blanche C, et al. Comparative efficacy of ring and suture annuloplasty for ischemic mitral regurgitation. Circulation. 1992;86(Suppl):II-46-52.
  9. Grossi EA, Lapietra A, Galloway AC, Ribakove GH, Culliford AT, Sposito RA, et al. Late results of isolated mitral annuloplasty for ischemic mitral insufficiency [abstract]. Circulation. 2000;102(Suppl):II-491.
  10. Timek T, Glasson JR, Dagum P, Green GR, Nistal JF, Komeda M, et al. Ring annuloplasty prevents delayed leaflet coaptation and mitral regurgitation during acute left ventricular ischemia. J Thorac Cardiovasc Surg. 2000;119:774-83.[Abstract/Free Full Text]
  11. Glasson JR, Green GR, Nistal JF, Dagum P, Komeda M, Daughters GT, et al. Mitral annular size and shape in sheep with annuloplasty rings. J Thorac Cardiovasc Surg. 1999;117:302-9.[Abstract/Free Full Text]
  12. Green GR, Dagum P, Glasson JR, Nistal JF, Daughters GT, Ingels NB Jr, et al. Restricted posterior leaflet motion after mitral ring annuloplasty. Ann Thorac Surg. 1999;68:2100-6.[Abstract/Free Full Text]
  13. van Rijk-Zwikker GL, Mast F, Schipperheyn JJ, Huysmans HA, Bruschke AV. Comparison of rigid and flexible rings for annuloplasty of the porcine mitral valve. Circulation. 1990;82(Suppl):IV-58-64.
  14. Glasson JR, Komeda M, Daughters GT, Foppiano LE, Bolger AF, Tye TL, et al. Most ovine mitral annular 3-D size reduction occurs before ventricular systole and is abolished with ventricular pacing. Circulation. 1997;96(Suppl):II-115-123.
  15. Niczyporuk MA, Miller DC. Automatic tracking and digitization of multiple radiopaque myocardial markers. Comput Biomed Res. 1991;24:129-42.[Medline]
  16. Daughters GT, Sanders WJ, Miller DC, Schwarzkopf A, Mead CW, Ingels NBJ. A comparison of two analytical systems for 3-D reconstruction from biplane videoradiograms. IEEE Comput Cardiol. 1989;15:79-82.
  17. Moon MR, DeAnda A, Daughters GT, Ingels NBJ, Miller DC. Experimental evaluation of different chordal preservation methods during mitral valve replacement. Ann Thorac Surg. 1994;58:931-44.[Abstract]
  18. Karlsson MO, Glasson JR, Bolger AF, Daughters GT, Komeda M, Foppiano LE, et al. Mitral valve opening in the ovine heart. Am J Physiol. 1998;274:H552-63.[Abstract/Free Full Text]
  19. Glasson JR, Komeda M, Daughters GT, Bolger AF, Karlsson MO, Foppiano LE, et al. Early systolic mitral leaflet "loitering" during acute ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 1998;116:193-205.[Abstract/Free Full Text]
  20. Gorman JH 3rd, Jackson BM, Gorman RC, Kelley ST, Gikakis N, Edmunds LH, Jr. Papillary muscle discoordination rather than increased annular area facilitates mitral regurgitation after acute posterior myocardial infarction. Circulation. 1997;96(Suppl):II-124-7.
  21. He S, Fontaine AA, Schwammenthal E, Yoganathan AP, Levine RA. Integrated mechanism for functional mitral regurgitation: leaflet restriction versus coapting force: in vitro studies. Circulation. 1997;96:1826-34.[Abstract/Free Full Text]
  22. Otsuji Y, Nathan N, Handschumacher MD, Coulter S, Liel-Cohen N, D'Ambra M, et al. Mechanism of ischemic mitral regurgitation: intraoperative evaluation of leaflet tethering geometry by three-dimensional geometry [abstract]. Circulation. 1997;96(Suppl):I-156.
  23. Kay GL, Kay JH, Zubiate P, Yokoyama T, Mendez M. Mitral valve repair for mitral regurgitation secondary to coronary artery disease. Circulation. 1986;74(Suppl):I-88-98.
  24. Gorman JH 3rd, Gorman RC, Jackson BM, Hiramatsu Y, Gikakis N, Kelley ST, et al. Distortions of the mitral valve in acute ischemic mitral regurgitation. Ann Thorac Surg. 1997;64:1026-31.[Abstract/Free Full Text]
  25. Green GR, Dagum P, Glasson JR, Daughters GT, Bolger AF, Foppiano LE, et al. Mitral annular dilatation and papillary muscle dislocation without mitral regurgitation in sheep. Circulation. 1999;100(Suppl):II-95-102.
  26. Lai DTM, Timek T, Green GR, Glasson JR, Daughters GT, Liang D, et al. The effects of ring annuloplasty on mitral leaflet geometry during acute left ventricular ischemia. J Thorac Cardiovasc Surg. 2000;120:966-75.[Abstract/Free Full Text]
  27. Izumi S, Miyatake K, Beppu S, Park YD, Nagata S, Kinoshita N, et al. Mechanism of mitral regurgitation in patients with myocardial infarction: a study using real-time two-dimensional Doppler flow imaging and echocardiography. Circulation. 1987;76:777-85.[Abstract/Free Full Text]
  28. Bolling SF, Pagani FD, Deeb GM, Bach DS. Intermediate-term outcome of mitral reconstruction in cardiomyopathy. J Thorac Cardiovasc Surg. 1998;115:381-8.[Abstract/Free Full Text]
  29. Dagum P, Timek T, Green GR, Lai D, Daughters GT, Liang D, et al. Coordinate-free analysis of mitral valve dynamics and ischemic hearts. Circulation. 2000;102(Suppl):III-62-9.
  30. Tsakiris AG, Von Bernuth G, Rastelli GC, Bourgeois MJ, Titus JL, Wood EH. Size and motion of the mitral valve annulus in anesthetized intact dogs. J Appl Physiol. 1971;30:611-8.[Free Full Text]
  31. Salgo IS GJ, Gorman RC, Jackson BM, Bowen F, Plappert TT, St John Sutton MG, et al. Structural implication of mitral annular geometry and the saddle shape: a finite element analysis [abstract]. Circulation. 2000;102(Suppl):II-631.
  32. Markovitz SE, Ratcliffe MB, Bavaria JE, Kreiner G, Iozzo RV, Hargrove WC, et al. Large animal model of left ventricular aneurysm. Ann Thorac Surg. 1989;48:838-45.[Abstract]
  33. Llaneras MR, Nance ML, Streicher JT, Lima JA, Savino JS, Bogen DK, et al. Large animal model of ischemic mitral regurgitation. Ann Thorac Surg. 1994;57:432-9.[Abstract]



This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
T. A. Timek, D. Liang, G. T. Daughters, N. B. Ingels Jr., and D. C. Miller
Effect of local annular interventions on annular and left ventricular geometry
Eur. J. Cardiothorac. Surg., June 1, 2008; 33(6): 1049 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Card Surg AdultHome page
W. Y. Szeto, R. C. Gorman, J. H. Gorman III, and M. A. Acker
Ischemic Mitral Regurgitation
Card. Surg. Adult, January 1, 2008; 3(2008): 785 - 802.
[Full Text]

Home page
 Card Surg AdultHome page
J. I. Fann, N. B. Ingels Jr., and D. C. Miller
Pathophysiology of Mitral Valve Disease
Card. Surg. Adult, January 1, 2008; 3(2008): 973 - 1012.
[Full Text]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T. C. Nguyen, A. Cheng, F. A. Tibayan, D. Liang, G. T. Daughters, N. B. Ingels Jr., and D. C. Miller
Septal-lateral annnular cinching perturbs basal left ventricular transmural strains
Eur. J. Cardiothorac. Surg., March 1, 2007; 31(3): 423 - 429.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. J. Mack
Percutaneous Mitral Valve Repair: A Fertile Field of Innovative Treatment Strategies
Circulation, May 16, 2006; 113(19): 2269 - 2271.
[Full Text] [PDF]

Home page
 CirculationHome page
J. H. Rogers, J. A. Macoviak, D. A. Rahdert, P. A. Takeda, I. F. Palacios, and R. I. Low
Percutaneous Septal Sinus Shortening: A Novel Procedure for the Treatment of Functional Mitral Regurgitation
Circulation, May 16, 2006; 113(19): 2329 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. K. Mishra, S. Mittal, P. Jaguri, and N. Trehan
Coapsys Mitral Annuloplasty for Chronic Functional Ischemic Mitral Regurgitation: 1-Year Results
Ann. Thorac. Surg., January 1, 2006; 81(1): 42 - 46.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. A. Levine and E. Schwammenthal
Ischemic Mitral Regurgitation on the Threshold of a Solution: From Paradoxes to Unifying Concepts
Circulation, August 2, 2005; 112(5): 745 - 758.
[Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
F. A. Tibayan, F. Rodriguez, F. Langer, M. K. Zasio, L. Bailey, D. Liang, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Annular or subvalvular approach to chronic ischemic mitral regurgitation?
J. Thorac. Cardiovasc. Surg., June 1, 2005; 129(6): 1266 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Maisano, A. Redaelli, M. Soncini, E. Votta, L. Arcobasso, and O. Alfieri
An Annular Prosthesis for the Treatment of Functional Mitral Regurgitation: Finite Element Model Analysis of a Dog Bone-Shaped Ring Prosthesis
Ann. Thorac. Surg., April 1, 2005; 79(4): 1268 - 1275.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H.-Y. Yu, M.-Y. Su, T.-Y. Liao, H.-H. Peng, F.-Y. Lin, and W.-Y. I. Tseng
Functional mitral regurgitation in chronic ischemic coronary artery disease: Analysis of geometric alterations of mitral apparatus with magnetic resonance imaging
J. Thorac. Cardiovasc. Surg., October 1, 2004; 128(4): 543 - 551.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. A. Timek, D. T. Lai, D. Liang, F. Tibayan, F. Langer, F. Rodriguez, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Effects of Paracommissural Septal-Lateral Annular Cinching on Acute Ischemic Mitral Regurgitation
Circulation, September 14, 2004; 110(11_suppl_1): II-79 - II-84.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. H. Kincaid, R. D. Riley, M. H. Hines, J. W. Hammon, and N. D. Kon
Anterior leaflet augmentation for ischemic mitral regurgitation
Ann. Thorac. Surg., August 1, 2004; 78(2): 564 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Inoue, P. M. McCarthy, Z. B. Popovic, K. Doi, S. Schenk, H. Nemeh, Y. Ootaki, M. W. Kopcak Jr, R. Dessoffy, J. D. Thomas, et al.
The Coapsys device to treat functional mitral regurgitation: In vivo long-term canine study
J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1068 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
K. Fukamachi, Z. B. Popovic, M. Inoue, K. Doi, S. Schenk, Y. Ootaki, M. W. Kopcak Jr., and P. M. McCarthy
Changes in mitral annular and left ventricular dimensions and left ventricular pressure-volume relations after off-pump treatment of mitral regurgitation with the Coapsys device
Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 352 - 357.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
F. A. Tibayan, F. Rodriguez, F. Langer, M. K. Zasio, L. Bailey, D. Liang, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Does septal-lateral annular cinching work for chronic ischemic mitral regurgitation?
J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 654 - 663.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. Sharony, P. C. Saunders, A. Nayar, E. McAleer, A. C. Galloway, J. Delianides, C. F. Schwartz, R. M. Applebaum, I. Kronzon, S. B. Colvin, et al.
Semirigid partial annuloplasty band allows dynamic mitral annular motion and minimizes valvular gradients: an echocardiographic study
Ann. Thorac. Surg., February 1, 2004; 77(2): 518 - 522.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Fukamachi, M. Inoue, Z. B. Popovic, K. Doi, S. Schenk, H. Nemeh, Y. Ootaki, M. W. Kopcak Jr, R. Dessoffy, J. D. Thomas, et al.
Off-pump mitral valve repair using the Coapsys device: a pilot study in a pacing-induced mitral regurgitation model
Ann. Thorac. Surg., February 1, 2004; 77(2): 688 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. M. Sundt III
Invited commentary
Ann. Thorac. Surg., February 1, 2004; 77(2): 693 - 693.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. A. Timek, G. R. Green, F. A. Tibayan, D. T. Lai, F. Rodriguez, D. Liang, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Aorto-mitral annular dynamics
Ann. Thorac. Surg., December 1, 2003; 76(6): 1944 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Kollar, V. Kekesi, P. Soos, and A. Juhasz-Nagy
Left ventricular external subannular plication: an indirect off-pump mitral annuloplasty method in a canine model
J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 977 - 982.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. Messas, B. Pouzet, B. Touchot, J. L. Guerrero, G. J. Vlahakes, M. Desnos, P. Menasche, A. Hagege, and R. A. Levine
Efficacy of Chordal Cutting to Relieve Chronic Persistent Ischemic Mitral Regurgitation
Circulation, September 9, 2003; 108(90101): II-111 - 115.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. A. Timek, S. L. Nielsen, D. T. Lai, F. A Tibayan, D. Liang, F. Rodriguez, G. T. Daughters, N. B. Ingels Jr, and D. C. Miller
Edge-to-Edge Mitral Valve Repair Without Ring Annuloplasty for Acute Ischemic Mitral Regurgitation
Circulation, September 9, 2003; 108(90101): II-122 - 127.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
E. A. Grossi, R. Sharony, and S. B. Colvin
Mitral valve in ischemic versus idiopathic dilated cardiomyopathy
J. Thorac. Cardiovasc. Surg., September 1, 2003; 126(3): 922 - 922.
[Full Text] [PDF]