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J Thorac Cardiovasc Surg 2003;125:1070-1082
© 2003 The American Association for Thoracic Surgery
Surgery for Congenital Heart Disease |
From the Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canadaa; the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NCb; the Division of Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canadac; the Division of Cardiovascular Surgery, Montreal Children's Hospital, Montreal, Quebec, Canadad; the Division of Cardiothoracic Surgery, St Christopher's Hospital for Children, Philadelphia, Pae; the Section of Cardiac Surgery, Children's Mercy Hospital, Kansas City, Mof; the Section of Cardiac Surgery, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michg; the Division of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, Pah; the Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohioi; and the Department of Cardiovascular Surgery, University of Toronto, Toronto, Ontario, Canada.j
The Congenital Heart Surgeons Society Data Center is supported by the member surgeons and the Hospital for Sick Children (Toronto). Dr Ashburn was supported by the Bradshaw Fellowship in Surgical Research from the Department of Surgery at Wake Forest University School of Medicine.
Received for publication May 29, 2002; revisions requested July 12, 2002; revisions received Sept 17, 2002. Accepted for publication Sept 24, 2002. Address for reprints: William G. Williams, MD, Hospital for Sick Children, Division of Cardiovascular Surgery, 555 University Ave, Toronto, Ontario M5G 1X8, Canada (E-mail: bill.williams{at}sickkids.ca).
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Abstract |
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 Top Abstract IntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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10 neonates, two institutions enrolling 
40 neonates), and procedural variables (shunt originating from aorta, longer circulatory arrest time, and management of the ascending aorta). Of neonates undergoing cavopulmonary shunt, 91% had reached a subsequent transition state by 6 years after cavopulmonary shunt, consisting of Fontan operation (79%), death (9%), or cardiac transplantation (3%). Risk factors for death occurring before subsequent transition included younger age at cavopulmonary shunt and need for right atrioventricular valve repair. |
Introduction |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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1 The vital anatomic component of classic HLHS is underdevelopment of the left ventricle-aorta complex, resulting in critical aortic valve stenosis (AVS) or aortic valve atresia (AVA) and a variable degree of hypoplasia of other left-sided heart structures. 2 Since the early 1980s, when Norwood and coworkers 3,4 popularized surgical palliation of HLHS, the prognosis for infants born with this lesion has dramatically improved from certain early death to an appreciable prospect of survival.
Previous reports from the Congenital Heart Surgeons Society (CHSS) on neonates with AVA or AVS have compared the selection of initial therapeutic approaches and their outcomes for each group. 5-7 Treatment options for neonates with AVA and for those with AVS not amenable to biventricular repair include staged surgical palliation and orthotopic cardiac transplantation. Staged surgical palliation has become the preferred option rather than cardiac transplantation in most institutions because of low donor organ supply, waiting list attrition, unknown long-term graft function and survival, necessity for chronic immunosuppressive therapy, and improvements in results after staged palliation.
Many reports address the outcomes for neonates with HLHS undergoing the Norwood operation and often incorporate variants of HLHS that are known to carry a better prognosis than classic HLHS. 8 Few have analyzed outcomes at each stage of palliation in the same cohort of patients, and none have used competing risks methodology. Although interstage attrition after the Norwood operation is an acknowledged problem, few reports have attempted to elucidate risk factors for death occurring after hospital discharge but before subsequent stages. 9,10 Because of these considerations, we constructed a competing risks analysis with data from a multi-institutional, longitudinal study to determine the prevalence of the various outcomes after the Norwood operation, to demonstrate the changes in risk with time associated with these outcomes, and to elucidate the demographic, anatomic, institutional, and surgical risk factors associated with each outcome.
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Patients and methods |
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TopAbstractIntroductionPatients and methodsResultsDiscussionAppendix: DiscussionReferences |
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Study population
Neonates younger than 30 days at the time of admission to a participating institution were eligible for inclusion. Morphologic criteria for entry included concordant atrioventricular and ventriculoarterial connections and either AVA or critical AVS. The surgical criterion for inclusion in this analysis was a Norwood operation. AVA was considered to be the absence of blood flow across the aortic valve, as determined by color Doppler echocardiography. AVS was considered to be important left ventricular outflow tract obstruction or hypoplasia, with demonstrated patency of the aortic valve and either moderately or severely reduced left ventricular function at admission or presence of duct-dependent systemic perfusion.
Norwood operation
Aortic reconstruction was performed with classic patch aortoplasty in 80%, with the Brawn-Mee modification 11,12 (distal aortic transection and arch reconstruction without prosthetic material) in 9%, with transection of the ascending aorta with reimplantation into the neoaorta in 9%, and with a modified technique consisting of pulmonary artery-arch anastomosis without proximal or distal aortic transection in 2%. The systemic-pulmonary arterial shunt most commonly originated from the innominate artery (84%), followed by the subclavian artery (7%), aorta (6%), and carotid artery (2%). Mean shunt diameter indexed to body weight was 1.15 ± 0.22 mm/kg. A 3.5-mm shunt was most commonly used (64%). A classic Blalock-Taussig shunt was used in 1% of the neonates. Median age at the Norwood operation was 6 days (range <1-140 days), and median weight was 3.2 kg (range 1.5-5.2 kg).
Data collection
Copies of medical records, including admission, diagnostic, and procedure reports, were requested for initial and subsequent assessments, admissions, or procedures and abstracted into a database by the Data Center and members of the CHSS. Detailed morphologic data were obtained by reviewing initial (before important intervention) echocardiographic videotape recordings from participating institutions. The protocol for this independent, blinded review has been described previously elsewhere. 5 Among the study population, initial echocardiograms were made available for 76% of neonates with AVS and for 57% of those with AVA.
Follow-up
The physician, family, or guardian of each child not known to have died has been contacted yearly since cohort inception to ascertain clinical status and any intervening problems or procedures. However, contact by the Data Center is dependent on institutional review board and parental consent at each institution, limiting potential follow-up. The most recent cross-sectional follow-up was conducted between May and August 2001 and was 76% complete. If cross-sectional follow-up data from 2000 are included for the 183 children without 2001 follow-up, 91% had cross-sectional follow-up data within 1 year of this analysis.
Data analysis
Goals of this analysis include defining the prevalence of various outcomes after the Norwood operation and determining the risk factors associated with each outcome. All analyses were performed with SAS statistical software (version 8; SAS Institute, Inc, Cary, NC). Data are given as frequency, median with range, or mean ± SD as appropriate.
Missing data
The number of nonmissing values is given for descriptive statistics. If weight, height, or body surface area was not reported, informative imputation was based on available patient characteristics and standard percentile growth charts, assuming that the patient's height and weight percentiles were concordant. If ascending aortic diameter was not available from echocardiographic review, values obtained from the operative record were used (n = 114). Inclusion of surgical values did not significantly affect the mean aortic diameter in either the AVA group (2.4 ± 0.9 mm vs. 2.5 ± 0.9 mm for echocardiography only, P = .20) or the AVS group (5.3 ± 1.8 mm vs. 5.4 ± 1.8 mm for echocardiography only, P = .44). Missing value indicator variables were created for missing continuous variables (eg, echocardiographic variables and circulatory arrest time), and the mean value of available information was imputed (noninformative imputation). In multivariable analyses, the relevant missing value indicator variables were carried to adjust for the possibility that patients with a given missing value may be different with respect to outcome from those in whom the value is not missing.
Competing risks after the Norwood operation
The following mutually exclusive states after the Norwood operation were designated: death, cavopulmonary shunt (CPS), other state (cardiac transplantation, biventricular repair in similar fashion to that described by Yasui and colleagues, 13 and Fontan operation), and survival without transition to a subsequent state. Rate of transition (hazard function) from the initial state to each competing state was determined, and these were synthesized to yield the proportion of neonates reaching defined transitional states at any given time after the Norwood operation. 14
Non-risk-adjusted nonparametric estimates of the time-related freedom from each state were plotted as Kaplan-Meier estimates. Modeling the hazard function, searching for multiple phases of risk, and elucidating the characteristic equation of each phase allowed computation of parametric estimates of time-related freedom from each chosen outcome event. 15
Demographic, institutional, morphologic, and surgical factors associated with each outcome after the Norwood operation were sought by multivariable analysis of the parametric models with the variables noted in Appendix Table 1. Variables associated with 5 or fewer events were eliminated from consideration to minimize the risk of model overdetermination. Bootstrap bagging was the primary tool for multivariable analysis, because it nearly perfectly balances the risks of false-positive and false-negative identification of risk factors. 16 For this, 1000 bootstrap data sets of the same size as the original data set were analyzed by automated stepwise regression with an inclusion criterion of P .1. This was followed by cluster analysis, with the results to yield risk factors occurring in 50% or more of the analyses and the most common occurring transformation of each continuous variable selected. To this were added other variables and interactions of interest, with the caveat of displaying the reliability of each factor according to the bagging analysis. Reported parameter estimates represent the contribution of a variable to the overall model. Variable increments and mathematic transformations affect interpretation of the contributions and are reported where applicable. The multivariable models were solved for multiple combinations of risk factors to explore the magnitude of effect of these factors and predict outcomes for neonates with given characteristics.
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Results |
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Competing risks after Norwood operation
Outcomes occurring after the Norwood operation are shown in time-independent fashion in Figure 1. Neonates transitioned to two major competing states: death (n = 261) and CPS (n = 377). Smaller numbers underwent direct transition to cardiac transplantation (n = 8), biventricular repair (n = 4), and Fontan operation (n = 1). Fifty-nine infants remain alive without transition to one of these states.
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, B). Six months after the Norwood operation, prevalence in various states included CPS (31%), death before a subsequent transition (37%), and other state (1%). The remaining 31% were surviving in the initial state. Between 6 months and 1 year after the Norwood operation, prevalence of death before subsequent transition did not appreciably change; however, prevalence of CPS increased to 57%.
Risk factors for post-Norwood mortality
Incremental risk factors for increased time-related death after the Norwood operation but before transition to any other state included patient-specific factors (lower birth weight, older age at Norwood, and smaller size of ascending aorta), surgical factors (shunt origin from neoaorta and longer circulatory arrest time), and institutional factors (institutions enrolling fewer than 10 neonates and 2 institutions enrolling more than 40 neonates; Table 1). The effects on survival of birth weight, age at Norwood operation, aortic origin of the shunt, and circulatory arrest time are shown in Appendix Figure 1. When institutions were excluded from risk factor selection, the technique of transecting and reimplanting the ascending aorta into the neoaorta was associated with increased survival in neonates with a small ascending aorta. Solving the multivariable equation while adjusting for other risk factors suggested a survival benefit for neonates with an ascending aorta measuring 3 mm or less if the ascending aorta was transected and reimplanted into the neoaorta (Figure 3).
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). Of 349 survivors of CPS, 199 progressed to the Fontan operation. Cardiac transplantation was performed in 8 children after CPS. No transition to a subsequent state has occurred in 142 children. Examination of the competing hazard functions for these states reveals a rapidly declining early phase for death occurring before subsequent state (Figure 8, A). Between 9 months and 18 months after CPS, a rapid increase in the rate of transition to the Fontan operation occurred, with subsequent slow decline during the next 4 years. On the basis of these hazard functions, the time-related prevalences of these states after CPS were determined (Figure 8, B).
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). Because of the small numbers of deaths and transplants, risk factors for these events could not be determined.
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Discussion |
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The overall post-Norwood survivals reported in this multi-institutional study are comparable to those in two earlier multi-institutional reports and several reports by high-volume centers. 8,17-21 Our early mortality data are also similar to those reported by the Society of Thoracic Surgeons National Congenital Heart Surgery Database, in which the operative mortality for 187 neonates undergoing the Norwood operation between 1994 and 1997 was 27%. 22
A number of reports from individual institutions have examined post-Norwood mortality and its associated risk factors. 17,20,21,23 Several of these studies have shown significant improvement in survival with time. Mahle and colleagues 20 from the Children's Hospital of Philadelphia reported the outcomes of 840 infants undergoing the Norwood operation between 1984 and 1999 in the largest single institutional series published to date. 20 Their center had improvements in hospital and 3-year survivals between 1984 to 1988 (56% and 28%, respectively) and 1995 to 1998 (71% and 66%, respectively). We did not demonstrate later date of birth or date of surgery to be a significant factor associated with post-Norwood survival, signifying no trend toward improved survival during the study's 6-year span.
We found increasing age at Norwood operation to be a risk factor for mortality in a continuous manner. Mahle and associates 20 found that age older than 14 days was a risk factor, and Bove and Lloyd 24 described increased risk for neonates older than 30 days. The potential for a neonate to undergo the Norwood operation days after birth is at least partially dependent on his or her postnatal clinical status. Tworetzky and colleagues 25 correlated improved clinical status and significantly younger age at operation with prenatal diagnosis. These observations emphasize the importance of early perinatal optimization of the neonate with the goal of early, but not emergency, Norwood operation.
Several groups have described the increased risk posed by low birth weight. 9,17,20,21 Weinstein and coworkers 26 reported an early mortality of 49% for 67 neonates smaller than 2.5 kg, compared with an overall early mortality of 26% at their institution. Delaying staged surgical reconstruction for the prospect of increasing neonatal weight is offset by the risk imposed by older age at operation. Although cardiac transplantation represents an alternative therapy for these neonates, there have been mixed reports regarding low birth weight as a risk factor for cardiac transplantation. A previous CHSS study 6 found lower birth weight to be a risk factor for infants with AVA entered into a transplant protocol, whereas a report from Razzouk and colleagues 27 at Loma Linda on a larger group of patients with HLHS did not find low birth weight to be a risk factor. At present, low birth weight is an immutable patient-specific factor for which no optimal solution is known.
There have been differing reports regarding the impact of ascending aortic size on survival. 5,6,9,20,28 Our data show an association between smaller ascending aortic size and post-Norwood mortality. The most important implication of the tiny ascending aorta involves compromise of coronary blood flow. 9 Anatomic subtype has also been purported to be a risk factor. 29 Although neonates with AVA had significantly smaller ascending aortas than those with AVS, neither AVA nor AVS emerged as significant risk factors. These data suggest that antegrade coronary flow potentially resulting from patency of the left-sided valves does not diminish the impact of the tiny ascending aorta. Technical modifications aimed at creating a durable, maximally patent coronary connection are expected to benefit neonates with a diminutive (<3 mm) ascending aorta.
Diastolic coronary blood flow has been shown to be impaired after the Norwood operation. 30 A systemic-pulmonary shunt originating from the aorta may reduce coronary perfusion to a greater degree than a more distal shunt by further reducing neoaortic diastolic blood pressure and increasing competing flow to the pulmonary arteries. That this phenomenon would not be well tolerated in the post-Norwood period is supported by previous reports of reduced baseline and maximal coronary blood flows, particularly in the setting of volume loading. 31 Shunt origin from the aorta as a risk factor for mortality has important implications in neonates with anomalous origin of the right subclavian artery. Because the carotid artery is often not suitable for shunt origin, alternate surgical technique is necessary in these neonates to decrease the risk conferred by aortic shunt origin.
Use of total circulatory arrest has been implicated in reducing neurodevelopmental outcomes of children who undergo staged palliation for HLHS. 32 Although our study did not assess neurologic outcomes, we found that increasing circulatory arrest time was associated with higher mortality after the Norwood operation. These findings illustrate the importance of minimizing the exposure of the neonate to ischemia. Although we observed no survival benefit associated with use of modified perfusion techniques, further data are needed to support the inference that modified regional perfusion could result in both survival and neurodevelopmental benefits.
Unexpected death after discharge from the surgical institution has been reported to range in prevalence from 4% to 15%. 10,21 Factors linked to interstage attrition by previous authors include perioperative arrhythmia, earlier date of operation, and atresia of the aortic and mitral valves. 9,10 We found a 12% mortality before CPS for hospital survivors of the Norwood operation. Our model accurately predicted the occurrence of these deaths, indicating that the same set of risk factors explain post-Norwood deaths whether they occur before or after hospital discharge. This finding is not surprising when one considers that impaired coronary perfusion or extremes of pulmonary blood flow accounted for 63% of deaths in a large postmortem series of Norwood nonsurvivors. 33 Although not specifically examined as a risk factor in our study, obstruction at the site of distal aortic arch reconstruction may also contribute to post-Norwood attrition. Nonetheless, the frequency of these deaths is of concern and indicates a need to improve the postdischarge evaluation and home management of these infants. Close echocardiographic surveillance of the central circulation in the near postoperative term could detect, and thus allow early correction of, hemodynamically important lesions in neonates with these risk factors.
Competing risks
Use of competing risks analysis allowed us to evaluate the efficiency with which survivors of the Norwood operation can be transitioned to the intermediate state of CPS. Although optimal timing of CPS in this population remains elusive, our data reveal that younger age is a risk factor for CPS mortality. One might consider that younger age at CPS is simply a marker for poorer progress after the Norwood operation, because we have demonstrated that survivors among neonates at increased risk for death also transition more rapidly to CPS. However, we found that postoperative oxygen saturation and indexed shunt size, which in addition to total cardiac output are related to the quantity of pulmonary blood flow, are predictors of the transition to CPS. Conversely, we did not find shunt size to be a factor associated with post-Norwood mortality. One might infer from these data that a larger shunt size indexed to body weight (1.15-1.25 mm/kg) and higher post-Norwood oxygen saturation (70%-80%) predict older age and therefore increased survival at CPS. However, further studies are needed to determine whether the survival benefit at CPS for older infants is offset by the deleterious effects of the longer duration of shunt-dependent physiology.
Study limitations
The multi-institutional nature of this study and its large cohort of patients provide a broad view of the status of staged surgical palliation for neonates with critical AVS or AVA. Although a comprehensive set of variables was used, missing data points are a potential weakness of the study. With currently available data, we could not explore the hemodynamic status of infants before subsequent staging. Incorporation of such data could allow determination of the optimal age for performing CPS and Fontan completion. Also, a combined analysis of outcomes after the Norwood operation and after cardiac transplantation could potentially define factors that would direct neonates toward the more beneficial pathway.
Conclusions
We have shown that patient, institutional, and procedural variables affect outcomes after the Norwood operation. Solution of the competing risks model for various levels of risk demonstrates that successful modification of these risk factors predicts better survival and more efficient transition to subsequent stages, which may lead to better outcomes for a larger proportion of neonates with HLHS undergoing the Norwood operation.
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Appendix: Discussion |
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I have the following questions for Dr Ashburn:
-blockade, we have a 1-month survival of 96% with subsequent survivals to 1 and 5 years of 79% and 77%. Dr Ashburn. We certainly are aware of the excellent results being presented from your institution, as well as from a number of other institutions, with particular improvement in recent years. Regarding improvement through time in the outcomes of these children, we did not find date of operation to be a statistically significant predictor of survival between 1994 and 2000. I noticed that you included in your breakdown 1996 to the present, and it may be that in the last 2 years since our study ended that the rate of improvement, considering new technology such as what your group has introduced, has made a difference in recent outcomes. Certainly, compared across decades of time there have been dramatic improvements reported in the literature, and one hopes that further improvement will continue.
We did not incorporate postoperative variables, such as hemodynamic, inotrope, blood gas, or ventilator management variables, into the analysis. I cannot comment on the impact of those factors on outcomes.
In a subsequent review and subanalysis, 77 infants were found to require reintervention for recurrent or residual distal aortic arch obstruction. According to the Kaplan-Meier method, the freedoms from reintervention for arch obstruction were 96%, 87%, and 84% at 3 months, 6 months, and 1 year, respectively. In a preliminary analysis, the technique of arch reconstruction did not arise as a risk factor for reintervention for recurrent arch obstruction. Although reintervention for recurrent coarctation was not shown to have a statistically significant impact on the overall survival after the Norwood operation, we believe that this issue requires further study.
The study revealed a strong logarithmic association of ascending aortic size with post-Norwood mortality. The technique of aortopulmonary anastomosis most commonly used in our population was the classic patch aortoplasty, in which the arch and ascending aorta are opened and connected to the neoaorta with an extensive patch. We do not have data on the cutback modification that you describe. However, I think the study shows that technical modifications that result in less kinking and distortion, as you suggest, and a more durable, patent coronary connection can be expected to improve survival of neonates with an ascending aorta smaller than 3 mm.
Regarding the competing risks analysis methodology, perhaps the biggest advantage is that it allows us to see what is happening to the overall group of patients at any given point in time. Use of competing risks also gives a more accurate representation of the prevalences of outcome events. It is really the time relatedness of how these events occur that is of interest. It's not uncommon to see raw mortality figures represented in an article, but we try to take that a step further and not only represent the mortality but explain the timing of the mortality and how it relates to other transitions that these patients may undergo. For instance, birth weight is a significant risk factor for death after the Norwood operation. By competing risks analysis, we also discovered that birth weight is a predictor of rate of transition to CPS. Those are the types of relationships that wouldn't come out of a different type of analysis.
Dr Thomas L. Spray (Philadelphia, Pa). The virtue of the multi-institutional CHSS studies is the fact that they give you a snapshot, if you will, of practice across a broad range of different institutions. But one of the disadvantages is the fact that a few institutions can significantly skew the data. For example, I wonder how many institutions there were that used the reimplantation strategy for the small ascending aorta. If you took a few institutions that used that strategy with very good results, would that skew the data to suggest that reimplantation was in fact favorable, when in fact other institutions—maybe many more institutions—where reimplantation wasn't used as a technique contributed many more patients with slightly worse outcomes? For example, if you took what I would call low-risk institutions for the standard reconstruction and compared those with the institutions that used reimplantation strategies, would you still find that reimplantation decreased the risk of early death?
In addition, I also wonder how you measured the ascending aortic diameter. It depends a lot on whether there is an independent observer looking at all patients to measure the diameter by echocardiography or whether it's a surgical measurement in the operating room and whether it's an estimate by the surgeon or by probing or whatever. The difference between 1 mm and 2 mm (100%) may be pretty subjective by estimation in the operating room.
Dr Ashburn. The morphologic variables were obtained by an independent blinded echocardiographic tape review. In the case of ascending aortic dimension, echocardiographic review values were preferentially used and account for 82% of the measurements. Where echocardiographic values were not available, ascending aortic dimension was obtained from the operative record, and such cases account for 18% of the measurements. Inclusion of operative values did not result in a statistically significant change in the mean values for either AVS or AVA when compared with echocardiographic values alone.
With regard to your question about ascending aortic reimplantation, eight institutions enrolled neonates in whom this technical modification was used. We did not perform risk adjustment for individual institutions, nor did we compare institutional outcomes with one another, so I cannot comment on the possible differential impact of ascending aortic management on the survivals at high-risk and low-risk institutions.
Dr Christian P. R. Brizard (Melbourne, Australia). I was surprised to hear that you found that young age for the CPS was a risk factor for death after CPS. In our institution we have been able to significantly reduce the attrition rate in the waiting period for the CPS by bringing forward the CPS to 3 months of age, with no increase in the mortality or morbidity of the CPS procedure. How do you explain your result? Also, from your statistical analysis, can you extrapolate to determine what would be the optimal age for the CPS?
Dr Ashburn. Your second question is of great interest to us, and we had hoped that we could answer it from this analysis. Unfortunately, we have not been able to put that analysis together at this point. I might add that incorporating hemodynamic data from the pre-CPS catheterization into such an analysis could be important in quantifying the time dependence of deleterious effects of shunt-dependent single-ventricle physiology in this these neonates.
With respect to why younger age at CPS increases risk, I think that it goes back to the risk factors for that transition. In our study the patients who were at risk for undergoing an earlier CPS also tended to be the patients who were at high risk for death after the Norwood operation. So those high-risk neonates who survived the Norwood operation but fared poorly were also more likely to do poorly at the time of CPS.
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Acknowledgments |
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Footnotes |
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B. Alsoufi, T. Karamlou, B. W. McCrindle, and C. A. Caldarone Management options in neonates and infants with critical left ventricular outflow tract obstruction Eur. J. Cardiothorac. Surg., June 1, 2007; 31(6): 1013 - 1021. [Abstract] [Full Text] [PDF]
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J. Li, G. Zhang, B. W. McCrindle, H. Holtby, T. Humpl, S. Cai, C. A. Caldarone, A. N. Redington, and G. S. Van Arsdell Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption after the Norwood procedure J. Thorac. Cardiovasc. Surg., February 1, 2007; 133(2): 441 - 448. [Abstract] [Full Text] [PDF]
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M. Nathan, D. Rimmer, P. J. del Nido, J. E. Mayer, E. A. Bacha, A. Shin, W. Regan, R. Gonzalez, and F. Pigula Aortic Atresia or Severe Left Ventricular Outflow Tract Obstruction with Ventricular Septal Defect: Results of Primary Biventricular Repair in Neonates Ann. Thorac. Surg., December 1, 2006; 82(6): 2227 - 2232. [Abstract] [Full Text] [PDF]
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J. H. Artrip, D. N. Campbell, D. D. Ivy, M. C. Almodovar, K.-C. Chan, M. B. Mitchell, D. R. Clarke, and F. Lacour-Gayet Birth Weight and Complexity Are Significant Factors for the Management of Hypoplastic Left Heart Syndrome. Ann. Thorac. Surg., October 1, 2006; 82(4): 1252 - 1259. [Abstract] [Full Text] [PDF]
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R. L. Hannan, M. A. Ybarra, J. W. Ojito, F. A. Alonso, A. F. Rossi, and R. P. Burke Complex Neonatal Single Ventricle Palliation Using Antegrade Cerebral Perfusion. Ann. Thorac. Surg., October 1, 2006; 82(4): 1278 - 1285. [Abstract] [Full Text] [PDF]
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O. Reinhartz, V. M. Reddy, E. Petrossian, M. MacDonald, J. J. Lamberti, S. J. Roth, G. E. Wright, S. B. Perry, S. Suleman, and F. L. Hanley Homograft Valved Right Ventricle to Pulmonary Artery Conduit as a Modification of the Norwood Procedure Circulation, July 4, 2006; 114(1_suppl): I-594 - I-599. [Abstract] [Full Text] [PDF]
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S. P. McGuirk, J. Stickley, M. Griselli, O. F. Stumper, S. J. Laker, D. J. Barron, and W. J. Brawn Risk assessment and early outcome following the Norwood procedure for hypoplastic left heart syndrome Eur. J. Cardiothorac. Surg., May 1, 2006; 29(5): 675 - 681. [Abstract] [Full Text] [PDF]
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N. Sinzobahamvya, J. Photiadis, D. Kumpikaite, C. Fink, H. C. Blaschczok, A. M. Brecher, and B. Asfour Comprehensive aristotle score: implications for the norwood procedure. Ann. Thorac. Surg., May 1, 2006; 81(5): 1794 - 1800. [Abstract] [Full Text] [PDF]
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G. Van Arsdell Invited commentary. Ann. Thorac. Surg., May 1, 2006; 81(5): 1800 - 1801. [Full Text] [PDF]
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J. Li, G. Zhang, H. M. Holtby, B. W. McCrindle, S. Cai, T. Humpl, C. A. Caldarone, W. G. Williams, A. N. Redington, and G. S. Van Arsdell Inclusion of oxygen consumption improves the accuracy of arterial and venous oxygen saturation interpretation after the Norwood procedure J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1099 - 1107. [Abstract] [Full Text] [PDF]
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 J. G. Berry, C. G. Cowley, C. J. Hoff, and R. Srivastava In-Hospital Mortality for Children With Hypoplastic Left Heart Syndrome After Stage I Surgical Palliation: Teaching Versus Nonteaching Hospitals Pediatrics, April 1, 2006; 117(4): 1307 - 1313. [Abstract] [Full Text] [PDF]
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C. D. Myers, J. H. Boyd, R. G. Presson Jr, P. Vijay, A. C. Coats, J. W. Brown, and M. D. Rodefeld Neonatal Cavopulmonary Assist: Pulsatile Versus Steady-Flow Pulmonary Perfusion Ann. Thorac. Surg., January 1, 2006; 81(1): 257 - 263. [Abstract] [Full Text] [PDF]
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C. D. Myers, K. Mattix, R. G. Presson Jr, P. Vijay, D. Maynes, K. N. Litwak, J. W. Brown, and M. D. Rodefeld Twenty-Four Hour Cardiopulmonary Stability in a Model of Assisted Newborn Fontan Circulation Ann. Thorac. Surg., January 1, 2006; 81(1): 264 - 271. [Abstract] [Full Text] [PDF]
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E. A. Bacha, S. Daves, J. Hardin, R.-i. Abdulla, J. Anderson, M. Kahana, P. Koenig, B. N. Mora, M. Gulecyuz, J. P. Starr, et al. Single-ventricle palliation for high-risk neonates: The emergence of an alternative hybrid stage I strategy J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 163 - 171. [Abstract] [Full Text] [PDF]
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T. Karamlou, D. A. Ashburn, C. A. Caldarone, E. H. Blackstone, R. A. Jonas, M. L. Jacobs, W. G. Williams, R. M. Ungerleider, B. W. McCrindle, and for the Members of the Congenital Heart Surgeons' Matching procedure to morphology improves outcomes in neonates with tricuspid atresia J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1503 - 1510. [Abstract] [Full Text] [PDF]
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M. L. Skinner, L. A. Halstead, C. S. Rubinstein, A. M. Atz, D. Andrews, and S. M. Bradley Laryngopharyngeal dysfunction after the Norwood procedure J. Thorac. Cardiovasc. Surg., November 1, 2005; 130(5): 1293 - 1301. [Abstract] [Full Text] [PDF]
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C. L. Cua, R. R. Thiagarajan, R. Taeed, T. M. Hoffman, L. Lai, J. Hayes, P. C. Laussen, and T. F. Feltes Improved Interstage Mortality With the Modified Norwood Procedure: A Meta-Analysis Ann. Thorac. Surg., July 1, 2005; 80(1): 44 - 49. [Abstract] [Full Text] [PDF]
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W. G. Williams Surgical outcomes in congenital heart disease: expectations and realities Eur. J. Cardiothorac. Surg., June 1, 2005; 27(6): 937 - 944. [Abstract] [Full Text] [PDF]
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S. Takabayashi, H. Kado, Y. Shiokawa, K. Fukae, and T. Nakano Comparison of hemodynamics between Norwood procedure and systemic-to-pulmonary artery shunt for single right ventricle patients Eur. J. Cardiothorac. Surg., June 1, 2005; 27(6): 968 - 974. [Abstract] [Full Text] [PDF]
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D. J. DiBardino, J. S. Heinle, D. A. Andropoulos, C. D. Kerr, D. L. S. Morales, and C. D. Fraser Jr Aortic Atresia and Type B Interrupted Aortic Arch: Diagnosis by Physiologic Cerebral Monitoring Ann. Thorac. Surg., May 1, 2005; 79(5): 1758 - 1760. [Abstract] [Full Text] [PDF]
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 U Theilen and L Shekerdemian The intensive care of infants with hypoplastic left heart syndrome Arch. Dis. Child. Fetal Neonatal Ed., March 1, 2005; 90(2): F97 - F102. [Abstract] [Full Text] [PDF]
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C. Pizarro, T. Mroczek, E. Malec, and W. I. Norwood Right Ventricle to Pulmonary Artery Conduit Reduces Interim Mortality After Stage 1 Norwood for Hypoplastic Left Heart Syndrome Ann. Thorac. Surg., December 1, 2004; 78(6): 1959 - 1964. [Abstract] [Full Text] [PDF]
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K. N. Fenton, F. A. Pigula, S. K. Gandhi, L. Russo, and K. F. Duncan Interim Mortality in Pulmonary Atresia With Intact Ventricular Septum Ann. Thorac. Surg., December 1, 2004; 78(6): 1994 - 1998. [Abstract] [Full Text] [PDF]
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N. C. De Oliveira, D. A. Ashburn, F. Khalid, H. M. Burkhart, I. T. Adatia, H. M. Holtby, W. G. Williams, and G. S. Van Arsdell Prevention of Early Sudden Circulatory Collapse After the Norwood Operation Circulation, September 14, 2004; 110(11_suppl_1): II-133 - II-138. [Abstract] [Full Text] [PDF]
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S. M. Bradley, J. M. Simsic, T. C. McQuinn, D. M. Habib, G. S. Shirali, and A. M. Atz Hemodynamic status after the Norwood procedure: A comparison of right ventricle-to-pulmonary artery connection versus modified blalock-taussig shunt Ann. Thorac. Surg., September 1, 2004; 78(3): 933 - 941. [Abstract] [Full Text] [PDF]
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A. J. B. Clarke, S. Kasahara, D. R. Andrews, S. G. Cooper, I. A. Nicholson, R. B. Chard, G. R. Nunn, and D. S. Winlaw Mid-Term results for double inlet left ventricle and similar morphologies: timing of Damus-Kaye-Stansel Ann. Thorac. Surg., August 1, 2004; 78(2): 650 - 657. [Abstract] [Full Text] [PDF]
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A. Azakie and I. A. Russell Gender differences in pediatric cardiac surgery: The surgeon's perspective J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 4 - 6. [Full Text] [PDF]
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 T. P. Graham Jr The year in congenital heart disease J. Am. Coll. Cardiol., June 2, 2004; 43(11): 2132 - 2141. [Full Text] [PDF]
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R. D. B. Jaquiss, N. S. Ghanayem, G. M. Hoffman, R. T. Fedderly, J. R. Cava, K. A. Mussatto, and J. S. Tweddell Early cavopulmonary anastomosis in very young infants after the Norwood procedure: Impact on oxygenation, resource utilization, and mortality J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 982 - 989. [Abstract] [Full Text] [PDF]
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M. D. Rodefeld, J. H. Boyd, C. D. Myers, R. G. Presson Jr, W. W. Wagner Jr, and J. W. Brown Cavopulmonary assist in the neonate: an alternative strategy for single-ventricle palliation J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 705 - 711. [Abstract] [Full Text] [PDF]
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