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J Thorac Cardiovasc Surg 2003;125:1170
© 2003 The American Association for Thoracic Surgery

Letters to the Editor

Indications for gadolinium for coronary angiography

Antoine Sarkis, MD, Georges Badaoui, MD, Victor A. Jebara, MD

Service de Chirurgie, Cardiovasculaire et Thoracique Hotel Dieu De France, Rue Adib Ishac Achrafieh, Beirut, Lebanon

To the Editor:

We read with great interest the article by Nicolosi and associatesGo 1 in the July 2002 issue of the Journal dealing with the beneficial effects of gadolinium on regional stunning in the canine heart in vivo.

Gadolinium is currently used to enhance magnetic resonance imaging and is known to be well tolerated by the kidneys. WeGo 2 recently reported the first clinical use of gadolinium for coronary angiography in a patient with elevated serum creatinine. We are currently conducting a prospective randomized trial to evaluate the exact role as well as the safety of gadolinium for coronary angiography in patients with abnormal renal function. Although none of our patients had any enzymatic or electrocardiographic changes in relation to myocardial damage, we are still wondering what the exact effects of this drug are on the myocardium. The article by Nicolosi and colleagues suggests that gadolinium is beneficial for the myocardium. This article, together with the promising results of our ongoing trial, might pave the way toward future indications for gadolinium for coronary angiography.

References

  1. Nicolosi AC, West G, Markley JG, Logan B. Olinger Gn. Gadolinium attenuates regional stunning in the canine heart in vivo. J Thorac Cardiovasc Surg. 2002;124:57-62.[Abstract/Free Full Text]
  2. Sarkis A, Badaoui G, Slaba S, Moussalli A, Jebara VA. Gadolinium-based coronarography in a patient with renal failure: first clinical report. Cathet Cardiovasc Interv. 2001;54:70-1.[Medline]




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