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J Thorac Cardiovasc Surg 2003;126:2116-2117
© 2003 The American Association for Thoracic Surgery

Letter to the editor

Myogenesis after myocardial stem cell transplantation

Syde Taheri, MD

9095 Main St, Suite C, Clarence, NY 14031, USA

To the Editor:

I read the article of Chedrawy and colleagues,1 "Incorporation and Integration of Implanted Myogenic and Stem Cells Into Native Myocardial Fibers: Anatomic Basis for Functional Improvements," in the Journal with great interest. Chedrawy and colleagues1 described regenerated isogenic myofebrile grafts injected into nonischemic normal myocardium. By 4 to 6 weeks, fully differentiated myocytes could be seen to interconnect among native cardiomyocytes. The authors attributed this desirable incorporation to cell-cell electromechanical junction. However, in a clinical setting with scar tissue and akinetic ventricular wall, the microenvironment is not conducive to electromechanical activity to induce a desirable environment to trigger phenotypic changes for transplanted cells. Is it possible that cytokines, such as transforming growth factor ß or insulin growth factor, generated because of the presence of macrophage and monocytes, play a role in the genesis of proliferation and transformation of new myofibrils?


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  1. Chedrawy EG, Wang JS, Nguyen DM, Shum-Tim D, Chiu RC. Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers: anatomic basis for functional improvements. J Thorac Cardiovasc Surg. 2002;124:584–590[Abstract/Free Full Text]




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