HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Igor Gregoric Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Frazier, O.H. Articles by Gregoric, I. Search for Related Content PubMed PubMed Citation Articles by Frazier, O.H. Articles by Gregoric, I. Related Collections Mechanical Circulatory Assistance

J Thorac Cardiovasc Surg 2004;128:625-626
© 2004 The American Association for Thoracic Surgery

Brief communication

Biventricular assistance with the Jarvik FlowMaker: A case report

^a Department of Surgery, Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Tex, USA

Received for publication October 31, 2003; accepted for publication February 25, 2004.

^* Address for reprints: O. H. Frazier, M.D., Texas Heart Institute, P. O. Box 20345, MC 3-147, Houston TX 77225-0345, USA
mmallia{at}heart.thi.tmc.edu

After implantation of a left ventricular assist device (LVAD), right ventricular dysfunction and elevated peripheral vascular resistance may result in right ventricular failure and increased mortality. Right ventricular support may become necessary, as in the following case in which two Jarvik FlowMakers (Jarvik Heart, Inc, New York, NY) provided biventricular assistance.

Clinical summary

A 21-year-old man with end-stage idiopathic cardiomyopathy was referred to our hospital and approved for heart transplantation. He had a left ventricular ejection fraction lower than 20% with mitral and tricuspid regurgitation. Despite maximal medical therapy and balloon counterpulsation, LVAD support became necessary as a lifesaving measure. A Jarvik FlowMaker was implanted in the left ventricle through a midline sternotomy with outflow graft anastomosis to the ascending aorta.¹ On postoperative day 1, the cardiac index increased by 60%, from 1.5 to 2.3 L/(min · m²). The patient was extubated on day 3. Two days later, he had ventricular tachycardia that responded to drug therapy and cardioversion. Sepsis supervened, hepatic function deteriorated, and the white blood cell count rose to 28.2 x 10³ cells/µL. On postoperative day 12, respiratory failure and bradycardia necessitated resuscitation and reintubation. Right ventricular function worsened, and tricuspid regurgitation became severe. A right atrial pressure greater than 20 mm Hg was required for adequate cardiac output. Hepatic function further deteriorated, and right ventricular support was clinically necessary. Because of the FlowMaker's unique suitability for intracardiac placement and its ease of implantation without cardiopulmonary bypass, this device was implanted for right ventricular support on postoperative day 15. A purse-string suture was placed on the upper lateral wall of the right atrium, and the pump was inserted into the atrium (Figure 1). The cardiac index increased to greater than 3.0 L/(min · m²), maintaining the central venous pressure at 5 to 10 cm H₂O. Unfortunately, because of progressive sepsis and hepatic failure, the patient died after 27 days of LVAD support and 12 days of biventricular support. Both pumps had a typical appearance at removal, and autopsy findings were unremarkable.

View larger version (74K): [in this window] [in a new window]   Figure 1. A, Configuration of biventricular FlowMaker system (right lateral viewpoint). B, Postoperative chest radiograph.

Although implantable pulsatile LVADs can save patients with end-stage heart failure, these devices may impair right ventricular function. This problem is usually overcome by relieving the high left-sided pressures typical of severe heart failure. However, when left ventricular filling remains inadequate despite pharmacotherapy to enhance right ventricular function and lower pulmonary vascular resistance, a right ventricular assist device may be required. Unfortunately, implantation is invariably delayed until end-organ failure is irreversible, and the mortality remains high even when a physiologic cardiac output is achieved.

Implantable pulsatile LVADs may decrease the left atrial and left ventricular pressures below normal physiologic levels. Pulsatility is generated as in the normal heart, with a systolic duration equivalent to about 33% of the cardiac cycle and a diastolic filling time like that of the normal heart. However, the pump's cycle is not synchronized with the patient's cardiac cycle. This lack of synchrony, along with subphysiologic left-sided pressures and a resultant ventricular and atrial septal shift (Figure 2), may impair natural right ventricular function. If left-sided filling is inadequate, the septal shift is accentuated. Attempts to enhance left-sided output by increasing device speed (in hopes of increasing flow) only worsen the situation.²

View larger version (50K): [in this window] [in a new window]   Figure 2. Echocardiograms showing atrial septal shift with left-sided support alone (A) and normalization of septum after placement of right-sided pump (B). S, Septum; LA, left atrium; RA, right atrium; L, left-sided pump; R, right-sided pump.

This therapy failed to save our critically ill patient. More timely implantation of a FlowMaker right ventricular assist device, along with a pulsatile or nonpulsatile LVAD, may be lifesaving in future cases. A FlowMaker right ventricular assist device alone may also be appropriate for long-term or destination therapy for isolated right ventricular failure or for congenital heart disease involving compromised or absent right ventricular function.

References

1. Westaby S, Frazier OH, Pigott DW, Saito S, Jarvik RK. Implant technique for the Jarvik 2000 Heart. Ann Thorac Surg. 2002;73:1337–1340[Abstract/Free Full Text]
   
2. Santamore WP, Gray LA. Left ventricular contributions to right ventricular systolic function during LVAD support. Ann Thorac Surg. 1996;61:350–356[Abstract/Free Full Text]
   

This article has been cited by other articles:

				T. Krabatsch, E. Potapov, A. Stepanenko, M. Schweiger, M. Kukucka, M. Huebler, E. Hennig, and R. Hetzer Biventricular Circulatory Support With Two Miniaturized Implantable Assist Devices Circulation, September 13, 2011; 124(11_suppl_1): S179 - S186. [Abstract] [Full Text] [PDF]

				J. M. Stulak, K. E. Griffith, J. M. Nicklas, and F. D. Pagani The use of the HeartWare HVAD for long-term right ventricular support after implantation of the HeartMate II device J. Thorac. Cardiovasc. Surg., September 1, 2011; 142(3): e140 - e142. [Full Text] [PDF]

				A. A. Pitsis, A. N. Visouli, V. Ninios, and D. T. Kremastinos Total ventricular assist for long-term treatment of heart failure J. Thorac. Cardiovasc. Surg., August 1, 2011; 142(2): 464 - 467. [Full Text] [PDF]

				E. C. McGee Jr, U. Ahmad, D. Tamez, M. Brown, N. Voskoboynikov, S. C. Malaisrie, R. Lee, and P. M. McCarthy Biventricular Continuous Flow VADs Demonstrate Diurnal Flow Variation and Lead to End-Organ Recovery Ann. Thorac. Surg., July 1, 2011; 92(1): e1 - e3. [Abstract] [Full Text] [PDF]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Igor Gregoric Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Frazier, O.H. Articles by Gregoric, I. Search for Related Content PubMed PubMed Citation Articles by Frazier, O.H. Articles by Gregoric, I. Related Collections Mechanical Circulatory Assistance