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J Thorac Cardiovasc Surg 2006;131:1422
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Correlation of autologous skeletal myoblast survival with changes in left ventricular remodeling in dilated ischemic heart failure

Helmut Gulbins, MD

Department of Cardiac Surgery, University Hospital Ulm, Steinhoevelstr. 9, Ulm D-89070, Germany

To the Editor:

McConnell and colleagues 1 Go present a well-designed study with implantation of skeletal myoblasts into an infarcted area. The infarction was created by interventional closing of the circumflex artery, and this resulted in dilated ischemic heart failure. The results, however, were somewhat disappointing. As assumed in the editorial by Tang, 2 Go the small number of surviving myoblasts could be one reason for this outcome. Of course, there might be several reasons for cell loss of transplanted cells, but one important issue has not been addressed by both authors: ischemia. The cardiomyocytes of the target area were lost because of insufficient blood supply. There is no reason why the transplanted cells should be more tolerant to ischemia than the native myocardial cells! Therefore the restoration of blood supply to an infarcted area is possibly one important measure to improve survival of transplanted cells. Additionally, further cell division and differentiation also depend on sufficient oxygen and nutrition supply.


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  1. McConnell PI, del Rio CL, Jacoby DB, Pavlicova M, Kwiatkowski P, Zawadzka A, et al. Correlation of autologous skeletal myoblast survival with changes in left ventricular remodeling in dilated ischemic heart failure. J Thorac Cardiovasc Surg 2005;130:1001.[Abstract/Free Full Text]
  2. Tang GH, Fazel S, Weisel RD, Verma S, Li RK. Optimizing cardiac cell therapy. from processing to delivery. J Thorac Cardiovasc Surg 2005;130:966-968.[Free Full Text]




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